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- PDB-2l8w: r(CCGCUGCGG)2 UU Internal Loop Found in Myotonic Dystrophy Type 1... -
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Open data
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Basic information
Entry | Database: PDB / ID: 2l8w | ||||||||||||||||||||||
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Title | r(CCGCUGCGG)2 UU Internal Loop Found in Myotonic Dystrophy Type 1 - UU pair with two hydrogen bond pairs | ||||||||||||||||||||||
![]() | RNA (5'-R(*![]() RNA / UU mismatch | Function / homology | RNA | ![]() Biological species | synthetic construct (others) | Method | SOLUTION NMR / molecular dynamics | Model details | fewest violations, model 1 | ![]() Parkesh, R. / Fountain, M. / Disney, M. | ![]() ![]() Title: NMR Spectroscopy and Molecular Dynamics Simulation of r(CCGCUGCGG)(2) Reveal a Dynamic UU Internal Loop Found in Myotonic Dystrophy Type 1. Authors: Parkesh, R. / Fountain, M. / Disney, M.D. History |
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Structure visualization
Structure viewer | Molecule: ![]() ![]() |
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Downloads & links
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Download
PDBx/mmCIF format | ![]() | 20.7 KB | Display | ![]() |
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PDB format | ![]() | 13 KB | Display | ![]() |
PDBx/mmJSON format | ![]() | Tree view | ![]() | |
Others | ![]() |
-Validation report
Summary document | ![]() | 398.3 KB | Display | ![]() |
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Full document | ![]() | 422.2 KB | Display | |
Data in XML | ![]() | 6.6 KB | Display | |
Data in CIF | ![]() | 6.8 KB | Display | |
Arichive directory | ![]() ![]() | HTTPS FTP |
-Related structure data
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Links
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Assembly
Deposited unit | ![]()
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1 |
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NMR ensembles |
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Components
#1: RNA chain | Mass: 2862.759 Da / Num. of mol.: 2 / Source method: obtained synthetically / Source: (synth.) synthetic construct (others) |
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-Experimental details
-Experiment
Experiment | Method: SOLUTION NMR Details: Structure of r(CCGCUGCGG)2 containing a UU mismatch | ||||||||||||||||
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NMR experiment |
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Sample preparation
Details | Contents: 1.5 mM RNA (5'-R(*CP*CP*GP*CP*UP*GP*CP*GP*G)-3'), 100% D2O Solvent system: 100% D2O |
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Sample | Conc.: 1.5 mM / Component: RNA (5'-R(*CP*CP*GP*CP*UP*GP*CP*GP*G)-3')-1 |
Sample conditions | Ionic strength: 0.01 / pH: 7.2 / Pressure: ambient / Temperature: 313 K |
-NMR measurement
NMR spectrometer | Type: Varian INOVA / Manufacturer: Varian / Model: INOVA / Field strength: 500 MHz |
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Processing
NMR software |
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Refinement | Method: molecular dynamics / Software ordinal: 1 | ||||||||||||||||||||
NMR representative | Selection criteria: fewest violations | ||||||||||||||||||||
NMR ensemble | Conformer selection criteria: structures with acceptable covalent geometry Conformers calculated total number: 25 / Conformers submitted total number: 1 |