Thiazolylpeptide-type bacteriocin precursor / defense response to bacterium / extracellular region / THIOPEPTIDE THIOSTREPTON WITH EPIMER FORM OF RESIDUE 9 / チオストレプトン
タイプ: Thiopeptideチオペプチド / クラス: 抗生剤抗生物質 / 分子量: 1736.923 Da / 分子数: 1 / 断片: residues 1-16 / 変異: (DCY)9C / 由来タイプ: 天然 詳細: THIOSTREPTON IS A HETEROCYCLIC THIOPEPTIDE, CONSISTING OF FOUR THIAZOLES ONE THIOZOLINE ONE PIPERIDEINE RINGS. A MODIFIED QUINOLINE, RESIDUE 0, IS LINKED TO MAIN-CHAIN RESIDUE 1 AND SIDE- ...詳細: THIOSTREPTON IS A HETEROCYCLIC THIOPEPTIDE, CONSISTING OF FOUR THIAZOLES ONE THIOZOLINE ONE PIPERIDEINE RINGS. A MODIFIED QUINOLINE, RESIDUE 0, IS LINKED TO MAIN-CHAIN RESIDUE 1 AND SIDE-CHAIN OF RESIDUE 12. IN THIS ENTRY RESIDUE 9 WAS CHEMICALLY MODIFIED FROM D-CYS TO L-CYS AND RESIDUE 17 (HET DHA) WAS DELETED. 由来: (天然) Streptomyces azureus (バクテリア) 参照: UniProt: P0C8P8, THIOPEPTIDE THIOSTREPTON WITH EPIMER FORM OF RESIDUE 9
構成要素の詳細
THIOSTREPTON IS A MEMBER OF A SULPHUR-RICH HETEROCYCLIC PEPTIDES CLASS. ALL SHARE A MACROCYCLIC ...THIOSTREPTON IS A MEMBER OF A SULPHUR-RICH HETEROCYCLIC PEPTIDES CLASS. ALL SHARE A MACROCYCLIC CORE, CONSISTING OF A NITROGEN CONTAINING, SIX-MEMBERED RING CENTRAL TO DEHYDROAMINO ACIDS AND A SUBSET OF FIVE MEMBER RING STRUCTURES INCLUDING THIAZOLES, THIAZOLINES AND OXAZOLES. HERE, THIOSTREPTON IS REPRESENTED BY THE SEQUENCE (SEQRES)
配列の詳細
A MODIFIED QUINOLINE LINKED TO THE MAIN-CHAIN OF RESIDUE 1 AND THE SIDE-CHAIN OF RESIDUE 12. THE ...A MODIFIED QUINOLINE LINKED TO THE MAIN-CHAIN OF RESIDUE 1 AND THE SIDE-CHAIN OF RESIDUE 12. THE RESIDUE 9 HAS BEEN MODIFIED TO CYS.
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実験情報
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実験
実験
手法: 溶液NMR 詳細: Thiostrepton derivative (epimer form of residue thc9:c5, in 5:1 chloroform-d ethanol-d5)
NMR実験
Conditions-ID
Experiment-ID
Solution-ID
タイプ
1
1
1
2D 1H-15N HSQC
1
2
1
2D 1H-13C HSQC
1
3
1
2D 1H-13C TOCSY-HSQC
1
4
1
2D 1H-13C HMBC
1
5
1
2D 1H-1H NOESY
1
6
1
2D 1H-1H ROESY
1
7
1
2D 1H-1H TOCSY
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試料調製
詳細
内容: 10 mM thiostrepton (epi,9), chloroform-d/ethanol-d5 5:1 溶媒系: chloroform-d/ethanol-d5 5:1
試料
濃度: 10 mM / 構成要素: thiostrepton (epi,9)
試料状態
圧: ambient / 温度: 298 K
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NMR測定
NMRスペクトロメーター
タイプ: Bruker DRX / 製造業者: Bruker / モデル: DRX / 磁場強度: 600 MHz