- PDB-2k4t: Solution structure of human VDAC-1 in LDAO micelles -
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Basic information
Entry
Database: PDB / ID: 2k4t
Title
Solution structure of human VDAC-1 in LDAO micelles
Components
Voltage-dependent anion-selective channel protein 1
Keywords
MEMBRANE PROTEIN / APOPTOSIS / Acetylation / Host-virus interaction / Ion transport / Membrane / Mitochondrion / Outer membrane / Phosphoprotein / Porin / Transmembrane / Transport Protein
Function / homology
Function and homology information
negative regulation of calcium import into the mitochondrion / positive regulation of parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization / voltage-gated monoatomic anion channel activity / neuron-neuron synaptic transmission / Mitochondrial calcium ion transport / ceramide binding / regulation of autophagy of mitochondrion / mitochondrial permeability transition pore complex / Pyruvate metabolism / Mitochondrial protein import ...negative regulation of calcium import into the mitochondrion / positive regulation of parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization / voltage-gated monoatomic anion channel activity / neuron-neuron synaptic transmission / Mitochondrial calcium ion transport / ceramide binding / regulation of autophagy of mitochondrion / mitochondrial permeability transition pore complex / Pyruvate metabolism / Mitochondrial protein import / phosphatidylcholine binding / oxysterol binding / monoatomic anion transport / pyruvate metabolic process / porin activity / cholesterol binding / pore complex / mitochondrial nucleoid / negative regulation of reactive oxygen species metabolic process / behavioral fear response / epithelial cell differentiation / PINK1-PRKN Mediated Mitophagy / learning / mitochondrial membrane / mitochondrial outer membrane / transmembrane transporter binding / Ub-specific processing proteases / membrane raft / apoptotic process / synapse / negative regulation of apoptotic process / protein kinase binding / mitochondrion / extracellular exosome / identical protein binding / membrane / nucleus / plasma membrane Similarity search - Function
Eukaryotic mitochondrial porin signature. / Porin, eukaryotic type / Eukaryotic porin/Tom40 / Eukaryotic porin / Porin / Porin domain superfamily / Porin / Beta Barrel / Mainly Beta Similarity search - Domain/homology
Voltage-dependentanion-selectivechannelprotein1 / VDAC-1 / hVDAC1 / Outer mitochondrial membrane protein porin 1 / Plasmalemmal porin / Porin 31HL / Porin 31HM
Mass: 31878.662 Da / Num. of mol.: 1 Source method: isolated from a genetically manipulated source Source: (gene. exp.) Homo sapiens (human) / Gene: VDAC1, VDAC / Plasmid: pET21a / Production host: Escherichia coli (E. coli) / Strain (production host): BL21(DE3) / References: UniProt: P21796
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Experimental details
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Experiment
Experiment
Method: SOLUTION NMR
NMR experiment
Type: 3D 1H-15N NOESY, 3D 1H-13C NOESY, 4D NUS-MDD-1H-13C-13C NOESY, 4D NUS-MDD-1H-15N-13C NOESY
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