Entry Database : PDB / ID : 2k20 Structure visualization Downloads & linksTitle Solution structure of Par-3 PDZ3 in complex with PTEN peptide ComponentsPartitioning-defective 3 homolog Protein tyrosine phosphatase and tensin homolog DetailsKeywords SIGNALING PROTEIN / Par-3 / PTEN / PDZ domain / Scaffold protein / Cell polarity / Alternative splicing / Cell cycle / Cell division / Cell junction / Coiled coil / Membrane / Phosphoprotein / Tight junctionFunction / homology Function and homology informationFunction Domain/homology Component
regulation of cellular component size / Negative regulation of the PI3K/AKT network / positive regulation of TRAIL-activated apoptotic signaling pathway / : / Synthesis of PIPs at the plasma membrane / Downstream TCR signaling / Ovarian tumor domain proteases / Tight junction interactions / Regulation of PTEN localization / regulation of myeloid cell apoptotic process ... regulation of cellular component size / Negative regulation of the PI3K/AKT network / positive regulation of TRAIL-activated apoptotic signaling pathway / : / Synthesis of PIPs at the plasma membrane / Downstream TCR signaling / Ovarian tumor domain proteases / Tight junction interactions / Regulation of PTEN localization / regulation of myeloid cell apoptotic process / phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase / negative regulation of keratinocyte migration / phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity / negative regulation of synaptic vesicle clustering / regulation of actin filament-based process / TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) / rhythmic synaptic transmission / inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity / central nervous system myelin maintenance / negative regulation of wound healing, spreading of epidermal cells / : / internode region of axon / Regulation of PTEN stability and activity / regulation of cellular localization / Synthesis of IP3 and IP4 in the cytosol / phosphatidylinositol-3-phosphate phosphatase activity / : / central nervous system neuron axonogenesis / PAR polarity complex / postsynaptic density assembly / negative regulation of dendritic spine morphogenesis / neuron-neuron synaptic transmission / apical constriction / negative regulation of potassium ion transmembrane transporter activity / cellular response to decreased oxygen levels / presynaptic membrane assembly / synapse maturation / negative regulation of axon regeneration / cellular response to electrical stimulus / negative regulation of cell cycle G1/S phase transition / : / establishment of centrosome localization / Ub-specific processing proteases / protein tyrosine/serine/threonine phosphatase activity / negative regulation of myelination / response to xenobiotic stimulus => GO:0009410 / negative regulation of ribosome biogenesis / negative regulation of axonogenesis / lateral loop / negative regulation of cardiac muscle cell proliferation / positive regulation of myelination / myelin sheath adaxonal region / establishment of epithelial cell polarity / phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity / negative regulation of excitatory postsynaptic potential / negative regulation of organ growth / forebrain morphogenesis / negative regulation of focal adhesion assembly / regulation of B cell apoptotic process / regulation of axon regeneration / Schmidt-Lanterman incisure / anaphase-promoting complex binding / bicellular tight junction assembly / phosphatidylinositol dephosphorylation / myelination in peripheral nervous system / prostate gland growth / negative regulation of cyclin-dependent protein serine/threonine kinase activity / dentate gyrus development / positive regulation of ubiquitin protein ligase activity / maternal behavior / positive regulation of ubiquitin-dependent protein catabolic process / negative regulation of cell size / phosphatidylinositol-3-phosphate binding / cellular response to leptin stimulus / response to arsenic-containing substance / dendritic spine morphogenesis / establishment or maintenance of epithelial cell apical/basal polarity / platelet-derived growth factor receptor binding / brain morphogenesis / negative regulation of epithelial to mesenchymal transition / cellular response to ethanol / cardiac muscle tissue development / protein targeting to membrane / long-term synaptic depression / negative regulation of phagocytosis / wound healing, spreading of cells / apical junction complex / cellular response to insulin-like growth factor stimulus / centrosome localization / regulation of synaptic transmission, GABAergic / negative regulation of G1/S transition of mitotic cell cycle / regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction / response to ATP / establishment of cell polarity / protein serine/threonine phosphatase activity / adult behavior / male mating behavior / response to zinc ion / protein-serine/threonine phosphatase / ubiquitin-specific protease binding Similarity search - Function : / Bifunctional phosphatidylinositol trisphosphate phosphatase/dual specificity phosphatase PTEN / Par3/HAL, N-terminal / N-terminal of Par3 and HAL proteins / Tensin phosphatase, C2 domain / Tensin-type phosphatase domain / C2 domain of PTEN tumour-suppressor protein / Phosphatase tensin-type domain profile. / C2 tensin-type domain profile. / C2 domain of PTEN tumour-suppressor protein ... : / Bifunctional phosphatidylinositol trisphosphate phosphatase/dual specificity phosphatase PTEN / Par3/HAL, N-terminal / N-terminal of Par3 and HAL proteins / Tensin phosphatase, C2 domain / Tensin-type phosphatase domain / C2 domain of PTEN tumour-suppressor protein / Phosphatase tensin-type domain profile. / C2 tensin-type domain profile. / C2 domain of PTEN tumour-suppressor protein / Dual specificity phosphatase, catalytic domain / Dual specificity phosphatase, catalytic domain / PDZ domain / Pdz3 Domain / Protein-tyrosine phosphatase, catalytic / Protein tyrosine phosphatase, catalytic domain motif / Tyrosine specific protein phosphatases active site. / Protein-tyrosine phosphatase, active site / Protein-tyrosine phosphatase-like / PDZ domain / PDZ domain profile. / Domain present in PSD-95, Dlg, and ZO-1/2. / PDZ domain / PDZ superfamily / Roll / Mainly Beta Similarity search - Domain/homology Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN / Partitioning defective 3 homolog Similarity search - ComponentBiological species Rattus norvegicus (Norway rat)Method SOLUTION NMR / torsion angle dynamics DetailsModel type details minimized average Authors Feng, W. / Wu, H. / Chan, L. / Zhang, M. CitationJournal : To be Published Title : Solution structure of Par-3 PDZ3 in complex with PTEN peptideAuthors : Feng, W. / Wu, H. / Chan, L. / Zhang, M. History Deposition Mar 18, 2008 Deposition site : BMRB / Processing site : RCSBRevision 1.0 Jun 10, 2008 Provider : repository / Type : Initial releaseRevision 1.1 Jul 13, 2011 Group : Version format complianceRevision 1.2 Mar 16, 2022 Group : Data collection / Database references / Derived calculationsCategory : database_2 / pdbx_nmr_software ... database_2 / pdbx_nmr_software / pdbx_struct_assembly / pdbx_struct_oper_list Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _pdbx_nmr_software.nameRevision 1.3 May 29, 2024 Group : Data collection / Category : chem_comp_atom / chem_comp_bond
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