Entry Database : PDB / ID : 2jku Structure visualization Downloads & linksTitle Crystal structure of the N-terminal region of the biotin acceptor domain of human propionyl-CoA carboxylase ComponentsPROPIONYL-COA CARBOXYLASE ALPHA CHAIN, MITOCHONDRIAL Details Keywords LIGASE / BIOTIN / ATP-BINDING / DISEASE MUTATION / NUCLEOTIDE-BINDING / MITOCHONDRION / PHOSPHOPROTEIN / TRANSIT PEPTIDEFunction / homology Function and homology informationFunction Domain/homology Component
short-chain fatty acid catabolic process / branched-chain amino acid metabolic process / Propionyl-CoA catabolism / propionyl-CoA carboxylase / propionyl-CoA carboxylase activity / Defective HLCS causes multiple carboxylase deficiency / Biotin transport and metabolism / biotin binding / catalytic complex / fatty acid metabolic process ... short-chain fatty acid catabolic process / branched-chain amino acid metabolic process / Propionyl-CoA catabolism / propionyl-CoA carboxylase / propionyl-CoA carboxylase activity / Defective HLCS causes multiple carboxylase deficiency / Biotin transport and metabolism / biotin binding / catalytic complex / fatty acid metabolic process / mitochondrial matrix / enzyme binding / mitochondrion / ATP binding / metal ion binding / cytosol Similarity search - Function Propionyl-coenzyme A carboxylase, BT domain / Propionyl-coenzyme A carboxylase BT domain / : / Biotin-binding site / Biotin-requiring enzymes attachment site. / Biotin carboxylase-like, N-terminal domain / Biotin carboxylase, C-terminal / Biotin carboxylation domain / Biotin carboxylase, N-terminal domain / Biotin carboxylase C-terminal domain ... Propionyl-coenzyme A carboxylase, BT domain / Propionyl-coenzyme A carboxylase BT domain / : / Biotin-binding site / Biotin-requiring enzymes attachment site. / Biotin carboxylase-like, N-terminal domain / Biotin carboxylase, C-terminal / Biotin carboxylation domain / Biotin carboxylase, N-terminal domain / Biotin carboxylase C-terminal domain / Biotin carboxylation domain profile. / Biotin carboxylase C-terminal domain / Carbamoyl-phosphate synthase subdomain signature 1. / Carbamoyl-phosphate synthetase large subunit-like, ATP-binding domain / Carbamoyl-phosphate synthase L chain, ATP binding domain / Biotin-requiring enzyme / Rudiment single hybrid motif / Biotinyl/lipoyl domain profile. / Biotin/lipoyl attachment / Single hybrid motif / ATP-grasp fold, subdomain 1 / Pre-ATP-grasp domain superfamily / ATP-grasp fold / ATP-grasp fold profile. / Carbamoyl-phosphate synthase subdomain signature 2. Similarity search - Domain/homologyBiological species HOMO SAPIENS (human)Method X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution : 1.5 Å DetailsAuthors Healy, S. / Yue, W.W. / Kochan, G. / Pilka, E.S. / Murray, J.W. / Roos, A.K. / Filippakopoulos, P. / von Delft, F. / Arrowsmith, C. / Wikstrom, M. ...Healy, S. / Yue, W.W. / Kochan, G. / Pilka, E.S. / Murray, J.W. / Roos, A.K. / Filippakopoulos, P. / von Delft, F. / Arrowsmith, C. / Wikstrom, M. / Edwards, A. / Bountra, C. / Gravel, R.A. / Oppermann, U. CitationJournal : Biochemistry / Year : 2010Title : Structural impact of human and Escherichia coli biotin carboxyl carrier proteins on biotin attachment.Authors : Healy, S. / McDonald, M.K. / Wu, X. / Yue, W.W. / Kochan, G. / Oppermann, U. / Gravel, R.A. History Deposition Aug 30, 2008 Deposition site : PDBE / Processing site : PDBERevision 1.0 Sep 9, 2008 Provider : repository / Type : Initial releaseRevision 1.1 Dec 4, 2013 Group : Source and taxonomy / Version format complianceRevision 1.2 Feb 28, 2018 Group : Database references / Category : citation / citation_authorItem : _citation.journal_id_ISSN / _citation.page_last ... _citation.journal_id_ISSN / _citation.page_last / _citation.pdbx_database_id_DOI / _citation.title / _citation_author.name Revision 1.3 Mar 4, 2020 Group : Derived calculations / OtherCategory : pdbx_database_status / pdbx_struct_assembly ... pdbx_database_status / pdbx_struct_assembly / pdbx_struct_assembly_gen / pdbx_struct_assembly_prop / pdbx_struct_oper_list Item : _pdbx_database_status.status_code_sf / _pdbx_struct_assembly.details ... _pdbx_database_status.status_code_sf / _pdbx_struct_assembly.details / _pdbx_struct_assembly.oligomeric_count / _pdbx_struct_assembly.oligomeric_details / _pdbx_struct_assembly_gen.oper_expression Revision 1.4 Dec 13, 2023 Group : Data collection / Database references ... Data collection / Database references / Derived calculations / Refinement description Category : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model / struct_site Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession ... _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _struct_site.pdbx_auth_asym_id / _struct_site.pdbx_auth_comp_id / _struct_site.pdbx_auth_seq_id
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