Entry | Database: PDB / ID: 2j67 |
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Title | The TIR domain of human Toll-Like Receptor 10 (TLR10) |
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Components | TOLL LIKE RECEPTOR 10 |
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Keywords | RECEPTOR / TIR / IL-1 / TOLL / TLR10 / MEMBRANE / INFLAMMATORY RESPONSE / TOLL-LIKE RECEPTOR 10 / INNATE IMMUNITY / IMMUNE RESPONSE / LEUCINE-RICH REPEAT / GLYCOPROTEIN / TRANSMEMBRANE |
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Function / homology | Function and homology information
toll-like receptor 10 signaling pathway / Toll Like Receptor 10 (TLR10) Cascade / regulation of cytokine production => GO:0001817 / NADP+ nucleosidase activity / IRAK4 deficiency (TLR5) / MyD88 cascade initiated on plasma membrane / ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase / NAD+ nucleotidase, cyclic ADP-ribose generating / MyD88-dependent toll-like receptor signaling pathway / toll-like receptor signaling pathway ...toll-like receptor 10 signaling pathway / Toll Like Receptor 10 (TLR10) Cascade / regulation of cytokine production => GO:0001817 / NADP+ nucleosidase activity / IRAK4 deficiency (TLR5) / MyD88 cascade initiated on plasma membrane / ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase / NAD+ nucleotidase, cyclic ADP-ribose generating / MyD88-dependent toll-like receptor signaling pathway / toll-like receptor signaling pathway / plasma membrane => GO:0005886 / positive regulation of inflammatory response / transmembrane signaling receptor activity / signaling receptor activity / inflammatory response / immune response / innate immune response / membrane / identical protein binding / plasma membraneSimilarity search - Function Toll-like receptor 10 / Toll/interleukin-1 receptor homology (TIR) domain / Toll-like receptor / TIR domain / Leucine Rich Repeat / Cysteine-rich flanking region, C-terminal / Leucine rich repeat C-terminal domain / Toll - interleukin 1 - resistance / TIR domain profile. / Toll/interleukin-1 receptor homology (TIR) domain ...Toll-like receptor 10 / Toll/interleukin-1 receptor homology (TIR) domain / Toll-like receptor / TIR domain / Leucine Rich Repeat / Cysteine-rich flanking region, C-terminal / Leucine rich repeat C-terminal domain / Toll - interleukin 1 - resistance / TIR domain profile. / Toll/interleukin-1 receptor homology (TIR) domain / Toll/interleukin-1 receptor homology (TIR) domain superfamily / Leucine rich repeat / Leucine-rich repeat, typical subtype / Leucine-rich repeats, typical (most populated) subfamily / Leucine-rich repeat profile. / Leucine-rich repeat / Leucine-rich repeat domain superfamily / Rossmann fold / 3-Layer(aba) Sandwich / Alpha BetaSimilarity search - Domain/homology |
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Biological species | HOMO SAPIENS (human) |
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Method | X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution: 2.2 Å |
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Authors | Stenmark, P. / Ogg, D. / Arrowsmith, C. / Berglund, H. / Busam, R. / Collins, R. / Edwards, A. / Ericsson, U.B. / Flodin, S. / Flores, A. ...Stenmark, P. / Ogg, D. / Arrowsmith, C. / Berglund, H. / Busam, R. / Collins, R. / Edwards, A. / Ericsson, U.B. / Flodin, S. / Flores, A. / Graslund, S. / Hammarstrom, M. / Hallberg, B.M. / Holmberg Schiavone, L. / Hogbom, M. / Johansson, I. / Karlberg, T. / Kotenyova, T. / Magnusdottir, A. / Nilsson, M.E. / Nilsson-Ehle, P. / Nyman, T. / Persson, C. / Sagemark, J. / Sundstrom, M. / Uppenberg, J. / Thorsell, A.G. / Van Den Berg, S. / Wallden, K. / Weigelt, J. / Welin, M. / Nordlund, P. |
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Citation | Journal: J.Biol.Chem. / Year: 2008 Title: The Crystal Structure of the Human Toll-Like Receptor 10 Cytoplasmic Domain Reveals a Putative Signaling Dimer. Authors: Nyman, T. / Stenmark, P. / Flodin, S. / Johansson, I. / Hammarstrom, M. / Nordlund, P. |
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History | Deposition | Sep 26, 2006 | Deposition site: PDBE / Processing site: PDBE |
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Revision 1.0 | Sep 27, 2006 | Provider: repository / Type: Initial release |
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Revision 1.1 | Jul 13, 2011 | Group: Advisory / Version format compliance |
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Revision 1.2 | Dec 13, 2023 | Group: Data collection / Database references ...Data collection / Database references / Other / Refinement description Category: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / database_2 / pdbx_database_status / pdbx_initial_refinement_model Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _pdbx_database_status.status_code_sf |
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