- PDB-2j5w: Ceruloplasmin revisited: structural and functional roles of vario... -
+
Open data
ID or keywords:
Loading...
-
Basic information
Entry
Database: PDB / ID: 2j5w
Title
Ceruloplasmin revisited: structural and functional roles of various metal cation binding sites
Components
CERULOPLASMIN
Keywords
OXIDOREDUCTASE / PLASMA PROTEIN / COPPER TRANSPORT / COPPER / TRANSPORT / POLYMORPHISM / GLYCOPROTEIN / MULTI-COPPER OXIDASE / CERULOPLASMIN / METAL-BINDING / ION TRANSPORT
Function / homology
Function and homology information
Defective SLC40A1 causes hemochromatosis 4 (HFE4) (macrophages) / Defective CP causes aceruloplasminemia (ACERULOP) / phospholipid-hydroperoxide glutathione peroxidase activity / Metal ion SLC transporters / cuproxidase / oxidoreductase activity, acting on metal ions, oxygen as acceptor / copper ion transport / glutathione peroxidase activity / ferroxidase / ferroxidase activity ...Defective SLC40A1 causes hemochromatosis 4 (HFE4) (macrophages) / Defective CP causes aceruloplasminemia (ACERULOP) / phospholipid-hydroperoxide glutathione peroxidase activity / Metal ion SLC transporters / cuproxidase / oxidoreductase activity, acting on metal ions, oxygen as acceptor / copper ion transport / glutathione peroxidase activity / ferroxidase / ferroxidase activity / intracellular copper ion homeostasis / side of membrane / Post-translational protein phosphorylation / Iron uptake and transport / Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) / iron ion transport / protein-folding chaperone binding / blood microparticle / intracellular iron ion homeostasis / oxidoreductase activity / copper ion binding / lysosomal membrane / endoplasmic reticulum lumen / extracellular space / extracellular exosome / extracellular region / plasma membrane Similarity search - Function
Resolution: 2.8→68.52 Å / Cor.coef. Fo:Fc: 0.945 / Cor.coef. Fo:Fc free: 0.908 / SU B: 9.268 / SU ML: 0.183 / Cross valid method: THROUGHOUT / ESU R: 0.394 / ESU R Free: 0.272 / Stereochemistry target values: MAXIMUM LIKELIHOOD / Details: HYDROGENS HAVE BEEN ADDED IN THE RIDING POSITIONS.
Rfactor
Num. reflection
% reflection
Selection details
Rfree
0.226
2608
5.1 %
RANDOM
Rwork
0.175
-
-
-
obs
0.177
48754
100 %
-
Solvent computation
Ion probe radii: 0.8 Å / Shrinkage radii: 0.8 Å / VDW probe radii: 1.4 Å / Solvent model: MASK