登録情報 | データベース: PDB / ID: 2j06 |
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タイトル | Crystal structure of the RasGAP SH3 domain at 1.8 Angstrom resolution |
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要素 | RAS GTPASE-ACTIVATING PROTEIN 1 |
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キーワード | SIGNAL TRANSDUCTION / GTPASE ACTIVATION / SH3 DOMAIN / SH2 DOMAIN / SRC HOMOLOGY 3 / RAS SIGNALING PATHWAY / GTPASE ACTIVATING PROTEIN / PROTO-ONCOGENE / PHOSPHORYLATION / DISEASE MUTATION |
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機能・相同性 | 機能・相同性情報
regulation of RNA metabolic process / regulation of actin filament polymerization / potassium channel inhibitor activity / negative regulation of cell adhesion / blood vessel morphogenesis / negative regulation of cell-matrix adhesion / mitotic cytokinesis / ephrin receptor signaling pathway / vasculogenesis / PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases ...regulation of RNA metabolic process / regulation of actin filament polymerization / potassium channel inhibitor activity / negative regulation of cell adhesion / blood vessel morphogenesis / negative regulation of cell-matrix adhesion / mitotic cytokinesis / ephrin receptor signaling pathway / vasculogenesis / PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases / ruffle / EPHB-mediated forward signaling / phosphotyrosine residue binding / Downstream signal transduction / GTPase activator activity / VEGFR2 mediated cell proliferation / Regulation of RAS by GAPs / GTPase binding / regulation of cell shape / negative regulation of neuron apoptotic process / intracellular signal transduction / signaling receptor binding / GTPase activity / negative regulation of apoptotic process / signal transduction / plasma membrane / cytoplasm / cytosol類似検索 - 分子機能 Ras GTPase-activating protein 1, N-terminal SH2 domain / RasGAP, SH3 domain / Ras GTPase-activating protein 1, C-terminal SH2 domain / Ras GTPase-activating protein / Ras GTPase-activating protein, conserved site / Ras GTPase-activating proteins domain signature. / GTPase-activator protein for Ras-like GTPase / Ras GTPase-activating proteins profile. / GTPase-activator protein for Ras-like GTPases / Ras GTPase-activating domain ...Ras GTPase-activating protein 1, N-terminal SH2 domain / RasGAP, SH3 domain / Ras GTPase-activating protein 1, C-terminal SH2 domain / Ras GTPase-activating protein / Ras GTPase-activating protein, conserved site / Ras GTPase-activating proteins domain signature. / GTPase-activator protein for Ras-like GTPase / Ras GTPase-activating proteins profile. / GTPase-activator protein for Ras-like GTPases / Ras GTPase-activating domain / Rho GTPase activation protein / C2 domain / Protein kinase C conserved region 2 (CalB) / C2 domain / C2 domain profile. / SH3 Domains / PH domain / C2 domain superfamily / PH domain profile. / Pleckstrin homology domain. / Pleckstrin homology domain / SH3 domain / SH2 domain / Src homology 2 (SH2) domain profile. / Src homology 2 domains / SH3 type barrels. / SH2 domain / Src homology 3 domains / SH2 domain superfamily / SH3-like domain superfamily / Src homology 3 (SH3) domain profile. / SH3 domain / PH-like domain superfamily / Roll / Mainly Beta類似検索 - ドメイン・相同性 |
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生物種 | HOMO SAPIENS (ヒト) |
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手法 | X線回折 / シンクロトロン / 単波長異常分散 / 解像度: 1.8 Å |
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データ登録者 | Ross, B. / Gajhede, M. / Kristensen, O. |
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引用 | ジャーナル: Biochem.Biophys.Res.Commun. / 年: 2007 タイトル: High Resolution Crystal Structures of the P120 Rasgap SH3 Domain. 著者: Ross, B. / Kristensen, O. / Favre, D. / Walicki, J. / Kastrup, J.S. / Widmann, C. / Gajhede, M. |
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履歴 | 登録 | 2006年8月1日 | 登録サイト: PDBE / 処理サイト: PDBE |
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改定 1.0 | 2007年1月2日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2011年5月8日 | Group: Version format compliance |
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改定 1.2 | 2011年7月13日 | Group: Version format compliance |
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