Netrin-1 signaling / phosphatidylinositol 3-kinase regulator activity / phosphatidylinositol 3-kinase activator activity / Flemming body / endosomal transport / protein kinase activator activity / positive regulation of protein kinase activity / GTPase activator activity / negative regulation of protein catabolic process / protein transport ...Netrin-1 signaling / phosphatidylinositol 3-kinase regulator activity / phosphatidylinositol 3-kinase activator activity / Flemming body / endosomal transport / protein kinase activator activity / positive regulation of protein kinase activity / GTPase activator activity / negative regulation of protein catabolic process / protein transport / actin cytoskeleton organization / negative regulation of neuron apoptotic process / endosome / GTPase activity / GTP binding / protein kinase binding / extracellular exosome / nucleoplasm / ATP binding / membrane / nucleus / metal ion binding / cytoplasm / cytosol Similarity search - Function
Arf GTPase activating protein / ArfGAP domain superfamily / Putative GTPase activating protein for Arf / ARF GTPase-activating proteins domain profile. / Putative GTP-ase activating proteins for the small GTPase, ARF / ARFGAP/RecO-like zinc finger / small GTPase Rab1 family profile. / PH domain profile. / Pleckstrin homology domain. / Pleckstrin homology domain ...Arf GTPase activating protein / ArfGAP domain superfamily / Putative GTPase activating protein for Arf / ARF GTPase-activating proteins domain profile. / Putative GTP-ase activating proteins for the small GTPase, ARF / ARFGAP/RecO-like zinc finger / small GTPase Rab1 family profile. / PH domain profile. / Pleckstrin homology domain. / Pleckstrin homology domain / Ras subfamily of RAS small GTPases / Small GTPase / Ras family / Ankyrin repeats (3 copies) / Rab subfamily of small GTPases / Ankyrin repeat profile. / Ankyrin repeat region circular profile. / Ankyrin repeat / Ankyrin repeat-containing domain superfamily / PH-like domain superfamily / P-loop containing nucleotide triphosphate hydrolases / P-loop containing nucleoside triphosphate hydrolase / Rossmann fold / 3-Layer(aba) Sandwich / Alpha Beta Similarity search - Domain/homology
Resolution: 1.5→45.74 Å / Cor.coef. Fo:Fc: 0.973 / Cor.coef. Fo:Fc free: 0.94 / SU B: 3.052 / SU ML: 0.052 / Cross valid method: THROUGHOUT / ESU R: 0.091 / ESU R Free: 0.084 / Stereochemistry target values: MAXIMUM LIKELIHOOD / Details: HYDROGENS HAVE BEEN ADDED IN THE RIDING POSITIONS.
Rfactor
Num. reflection
% reflection
Selection details
Rfree
0.214
1019
4.1 %
RANDOM
Rwork
0.15
-
-
-
obs
0.152
23903
99.3 %
-
Solvent computation
Ion probe radii: 0.8 Å / Shrinkage radii: 0.8 Å / VDW probe radii: 1.4 Å / Solvent model: BABINET MODEL WITH MASK