Entry Database : PDB / ID : 2iv8 Structure visualization Downloads & linksTitle beta appendage in complex with b-arrestin peptide ComponentsAP-2 COMPLEX SUBUNIT BETA-1 BETA-ARRESTIN-1 DetailsKeywords ENDOCYTOSIS/REGULATOR / ENDOCYTOSIS-REGULATOR COMPLEX / SENSORY TRANSDUCTION / RECEPTOR / COATED PITS / ADAPTOR COMPLEX-REGULATORFunction / homology Function and homology informationFunction Domain/homology Component
angiotensin receptor binding / Nef Mediated CD8 Down-regulation / clathrin adaptor complex / WNT5A-dependent internalization of FZD2, FZD5 and ROR2 / Trafficking of GluR2-containing AMPA receptors / WNT5A-dependent internalization of FZD4 / AP-2 adaptor complex / postsynaptic neurotransmitter receptor internalization / Activation of SMO / Retrograde neurotrophin signalling ... angiotensin receptor binding / Nef Mediated CD8 Down-regulation / clathrin adaptor complex / WNT5A-dependent internalization of FZD2, FZD5 and ROR2 / Trafficking of GluR2-containing AMPA receptors / WNT5A-dependent internalization of FZD4 / AP-2 adaptor complex / postsynaptic neurotransmitter receptor internalization / Activation of SMO / Retrograde neurotrophin signalling / negative regulation of interleukin-8 production / clathrin-coated endocytic vesicle / LDL clearance / clathrin-dependent endocytosis / coronary vasculature development / arrestin family protein binding / G protein-coupled receptor internalization / signal sequence binding / Nef Mediated CD4 Down-regulation / endolysosome membrane / enzyme inhibitor activity / aorta development / ventricular septum development / Lysosome Vesicle Biogenesis / clathrin binding / positive regulation of Rho protein signal transduction / Golgi Associated Vesicle Biogenesis / negative regulation of NF-kappaB transcription factor activity / stress fiber assembly / negative regulation of Notch signaling pathway / pseudopodium / Recycling pathway of L1 / negative regulation of interleukin-6 production / positive regulation of receptor internalization / synaptic vesicle endocytosis / EPH-ephrin mediated repulsion of cells / clathrin-coated pit / vesicle-mediated transport / negative regulation of protein ubiquitination / visual perception / MHC class II antigen presentation / VLDLR internalisation and degradation / Activated NOTCH1 Transmits Signal to the Nucleus / GTPase activator activity / kidney development / G protein-coupled receptor binding / intracellular protein transport / insulin-like growth factor receptor binding / Signaling by high-kinase activity BRAF mutants / clathrin-coated endocytic vesicle membrane / MAP2K and MAPK activation / cytoplasmic vesicle membrane / cytoplasmic side of plasma membrane / Signaling by RAF1 mutants / Signaling by moderate kinase activity BRAF mutants / Paradoxical activation of RAF signaling by kinase inactive BRAF / Signaling downstream of RAS mutants / endocytic vesicle membrane / Signaling by BRAF and RAF1 fusions / protein transport / Thrombin signalling through proteinase activated receptors (PARs) / Cargo recognition for clathrin-mediated endocytosis / presynapse / Clathrin-mediated endocytosis / cytoplasmic vesicle / ubiquitin-dependent protein catabolic process / G alpha (s) signalling events / postsynapse / proteasome-mediated ubiquitin-dependent protein catabolic process / Potential therapeutics for SARS / transcription coactivator activity / positive regulation of ERK1 and ERK2 cascade / nuclear body / Ub-specific processing proteases / protein ubiquitination / positive regulation of protein phosphorylation / lysosomal membrane / Golgi membrane / glutamatergic synapse / ubiquitin protein ligase binding / chromatin / regulation of transcription by RNA polymerase II / signal transduction / positive regulation of transcription by RNA polymerase II / nucleoplasm / membrane / nucleus / plasma membrane / cytoplasm / cytosol Similarity search - Function Immunoglobulin-like - #1150 / TATA-Binding Protein / Arrestin, conserved site / Arrestins signature. / Arrestin / Arrestin, N-terminal / Clathrin adaptor, beta-adaptin, appendage, Ig-like subdomain / Beta-adaptin appendage, C-terminal subdomain / AP-1/2/4 complex subunit beta / Beta2-adaptin appendage, C-terminal sub-domain ... Immunoglobulin-like - #1150 / TATA-Binding Protein / Arrestin, conserved site / Arrestins signature. / Arrestin / Arrestin, N-terminal / Clathrin adaptor, beta-adaptin, appendage, Ig-like subdomain / Beta-adaptin appendage, C-terminal subdomain / AP-1/2/4 complex subunit beta / Beta2-adaptin appendage, C-terminal sub-domain / Beta2-adaptin appendage, C-terminal sub-domain / AP complex subunit beta / Arrestin-like, N-terminal / Arrestin C-terminal-like domain / Arrestin (or S-antigen), N-terminal domain / Arrestin (or S-antigen), C-terminal domain / Arrestin (or S-antigen), C-terminal domain / Coatomer/calthrin adaptor appendage, C-terminal subdomain / Arrestin-like, C-terminal / Clathrin adaptor, alpha/beta/gamma-adaptin, appendage, Ig-like subdomain / Adaptin C-terminal domain / Adaptin C-terminal domain / Clathrin/coatomer adaptor, adaptin-like, N-terminal / Adaptin N terminal region / Clathrin adaptor, appendage, Ig-like subdomain superfamily / TATA-Binding Protein / TBP domain superfamily / Armadillo/beta-catenin-like repeats / Armadillo / Armadillo-like helical / Immunoglobulin E-set / Armadillo-type fold / Immunoglobulin-like / Sandwich / 2-Layer Sandwich / Mainly Beta / Alpha Beta Similarity search - Domain/homologyBiological species HOMO SAPIENS (human)Method X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution : 2.8 Å DetailsAuthors Ford, M.G.J. / Schmid, E.M. / McMahon, H.T. CitationJournal : Plos Biol. / Year : 2006Title : Role of the Ap2 Beta-Appendage Hub in Recruiting Partners for Clathrin-Coated Vesicle Assembly.Authors : Schmid, E.M. / Ford, M.G.J. / Burtey, A. / Praefcke, G.J.K. / Peak-Chew, S. / Mills, I.G. / Benmerah, A. / Mcmahon, H.T. History Deposition Jun 8, 2006 Deposition site : PDBE / Processing site : PDBERevision 1.0 Jun 12, 2007 Provider : repository / Type : Initial releaseRevision 1.1 Jul 13, 2011 Group : Advisory / Version format complianceRevision 1.2 Dec 13, 2023 Group : Data collection / Database references ... Data collection / Database references / Other / Refinement description Category : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / database_2 / pdbx_database_status / pdbx_initial_refinement_model Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _pdbx_database_status.status_code_sf
Show all Show less Remark 700 SHEET THE SHEET STRUCTURE OF THIS MOLECULE IS BIFURCATED. IN ORDER TO REPRESENT THIS FEATURE IN ... SHEET THE SHEET STRUCTURE OF THIS MOLECULE IS BIFURCATED. IN ORDER TO REPRESENT THIS FEATURE IN THE SHEET RECORDS BELOW, TWO SHEETS ARE DEFINED.