登録情報 | データベース: PDB / ID: 2iiv |
---|
タイトル | Human dipeptidyl peptidase 4 in complex with a diazepan-2-one inhibitor |
---|
要素 | Dipeptidyl peptidase 4 soluble form |
---|
キーワード | HYDROLASE / ALPHA/BETA / BETA-PROPELLER / DIMER |
---|
機能・相同性 | 機能・相同性情報
glucagon processing / negative regulation of neutrophil chemotaxis / regulation of cell-cell adhesion mediated by integrin / Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) / negative regulation of extracellular matrix disassembly / psychomotor behavior / dipeptidyl-peptidase IV / intercellular canaliculus / chemorepellent activity / dipeptidyl-peptidase activity ...glucagon processing / negative regulation of neutrophil chemotaxis / regulation of cell-cell adhesion mediated by integrin / Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) / negative regulation of extracellular matrix disassembly / psychomotor behavior / dipeptidyl-peptidase IV / intercellular canaliculus / chemorepellent activity / dipeptidyl-peptidase activity / peptide hormone processing / locomotory exploration behavior / lamellipodium membrane / endocytic vesicle / endothelial cell migration / behavioral fear response / aminopeptidase activity / T cell costimulation / T cell activation / serine-type peptidase activity / Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) / lamellipodium / virus receptor activity / protease binding / receptor-mediated endocytosis of virus by host cell / membrane fusion / receptor-mediated virion attachment to host cell / response to hypoxia / cell adhesion / symbiont entry into host cell / apical plasma membrane / membrane raft / lysosomal membrane / serine-type endopeptidase activity / signaling receptor binding / focal adhesion / positive regulation of cell population proliferation / cell surface / protein homodimerization activity / proteolysis / extracellular exosome / extracellular region / identical protein binding / membrane / plasma membrane類似検索 - 分子機能 Dipeptidylpeptidase IV, N-terminal domain / : / 8 Propeller / Methanol Dehydrogenase; Chain A / Prolyl endopeptidase family serine active site. / Peptidase S9, serine active site / Dipeptidylpeptidase IV, N-terminal domain / Dipeptidyl peptidase IV (DPP IV) N-terminal region / Peptidase S9, prolyl oligopeptidase, catalytic domain / Prolyl oligopeptidase family ...Dipeptidylpeptidase IV, N-terminal domain / : / 8 Propeller / Methanol Dehydrogenase; Chain A / Prolyl endopeptidase family serine active site. / Peptidase S9, serine active site / Dipeptidylpeptidase IV, N-terminal domain / Dipeptidyl peptidase IV (DPP IV) N-terminal region / Peptidase S9, prolyl oligopeptidase, catalytic domain / Prolyl oligopeptidase family / Alpha/Beta hydrolase fold, catalytic domain / Alpha/Beta hydrolase fold / Rossmann fold / 3-Layer(aba) Sandwich / Mainly Beta / Alpha Beta類似検索 - ドメイン・相同性 |
---|
生物種 | Homo sapiens (ヒト) |
---|
手法 | X線回折 / シンクロトロン / フーリエ合成 / 解像度: 2.15 Å |
---|
データ登録者 | Scapin, G. / Weber, A.E. / Biftu, T. |
---|
引用 | ジャーナル: Bioorg.Med.Chem.Lett. / 年: 2007 タイトル: (3R)-4-[(3R)-3-Amino-4-(2,4,5-trifluorophenyl)butanoyl]-3-(2,2,2-trifluoroethyl)-1,4-diazepan-2-one, a selective dipeptidyl peptidase IV inhibitor for the treatment of type 2 diabetes 著者: Biftu, T. / Feng, D. / Qian, X. / Liang, G.B. / Kieczykowski, G. / Eiermann, G. / He, H. / Leiting, B. / Lyons, K. / Petrov, A. / Sinha-Roy, R. / Zhang, B. / Scapin, G. / Patel, S. / Gao, Y.D. ...著者: Biftu, T. / Feng, D. / Qian, X. / Liang, G.B. / Kieczykowski, G. / Eiermann, G. / He, H. / Leiting, B. / Lyons, K. / Petrov, A. / Sinha-Roy, R. / Zhang, B. / Scapin, G. / Patel, S. / Gao, Y.D. / Singh, S. / Wu, J. / Zhang, X. / Thornberry, N.A. / Weber, A.E. |
---|
履歴 | 登録 | 2006年9月28日 | 登録サイト: RCSB / 処理サイト: RCSB |
---|
改定 1.0 | 2006年11月28日 | Provider: repository / タイプ: Initial release |
---|
改定 1.1 | 2008年5月1日 | Group: Version format compliance |
---|
改定 1.2 | 2011年7月13日 | Group: Non-polymer description / Version format compliance |
---|
改定 1.3 | 2017年10月18日 | Group: Refinement description / カテゴリ: software / Item: _software.name |
---|
改定 2.0 | 2020年7月29日 | Group: Advisory / Atomic model ...Advisory / Atomic model / Data collection / Derived calculations / Structure summary カテゴリ: atom_site / chem_comp ...atom_site / chem_comp / database_PDB_caveat / entity / pdbx_branch_scheme / pdbx_chem_comp_identifier / pdbx_entity_branch / pdbx_entity_branch_descriptor / pdbx_entity_branch_link / pdbx_entity_branch_list / pdbx_entity_nonpoly / pdbx_nonpoly_scheme / pdbx_struct_assembly_gen / pdbx_validate_chiral / struct_asym / struct_conn / struct_site / struct_site_gen Item: _atom_site.B_iso_or_equiv / _atom_site.Cartn_x ..._atom_site.B_iso_or_equiv / _atom_site.Cartn_x / _atom_site.Cartn_y / _atom_site.Cartn_z / _atom_site.auth_asym_id / _atom_site.auth_atom_id / _atom_site.auth_comp_id / _atom_site.auth_seq_id / _atom_site.label_asym_id / _atom_site.label_atom_id / _atom_site.label_comp_id / _atom_site.label_entity_id / _atom_site.type_symbol / _chem_comp.name / _chem_comp.type / _pdbx_entity_nonpoly.entity_id / _pdbx_entity_nonpoly.name / _pdbx_struct_assembly_gen.asym_id_list / _pdbx_validate_chiral.auth_asym_id / _pdbx_validate_chiral.auth_seq_id / _struct_conn.pdbx_leaving_atom_flag / _struct_conn.pdbx_role / _struct_conn.ptnr1_auth_asym_id / _struct_conn.ptnr1_auth_seq_id / _struct_conn.ptnr1_label_asym_id / _struct_conn.ptnr2_auth_asym_id / _struct_conn.ptnr2_auth_seq_id / _struct_conn.ptnr2_label_asym_id 解説: Carbohydrate remediation / Provider: repository / タイプ: Remediation |
---|
改定 2.1 | 2021年10月20日 | Group: Database references / Structure summary / カテゴリ: chem_comp / database_2 / struct_ref_seq_dif Item: _chem_comp.pdbx_synonyms / _database_2.pdbx_DOI ..._chem_comp.pdbx_synonyms / _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _struct_ref_seq_dif.details |
---|
改定 2.2 | 2023年8月30日 | Group: Data collection / Refinement description カテゴリ: chem_comp_atom / chem_comp_bond / pdbx_initial_refinement_model |
---|
|
---|