BIOMOLECULE: 1 THIS ENTRY CONTAINS THE CRYSTALLOGRAPHIC ASYMMETRIC UNIT WHICH CONSISTS OF 2 ... BIOMOLECULE: 1 THIS ENTRY CONTAINS THE CRYSTALLOGRAPHIC ASYMMETRIC UNIT WHICH CONSISTS OF 2 CHAIN(S). SEE REMARK 350 FOR INFORMATION ON GENERATING THE BIOLOGICAL MOLECULE(S). According to authors:This crystal structure reveals domain swapping of the N-terminal 55 residues between neighbouring molecules of MetRS-N (chain A of this entry) related by a true crystallographic 2-fold axis, effectively generating a tetramer of 2:2 composition. As discussed in detail in the literature reference of this entry, this phenomenon is an artifact of heterologous recombinant overexpression of MetRS-N in E. coli. Full-length MetRS purified from yeast is a monomer and engages in a 1:1 interaction with Arc1p (Deinert et al. (2001) JBC 276, 6000-6008).
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