登録情報 データベース : PDB / ID : 2hjh 構造の表示 ダウンロードとリンクタイトル Crystal Structure of the Sir2 deacetylase 要素NAD-dependent histone deacetylase SIR2 詳細 キーワード HYDROLASE / protein / sirtuin / acetyl-adp-ribose / nicotinamide機能・相同性 機能・相同性情報分子機能 ドメイン・相同性 構成要素
regulation of mating type switching / negative regulation of DNA amplification / RENT complex / regulation of DNA stability / NAD-dependent histone H3K14 deacetylase activity / establishment of protein-containing complex localization to telomere / NAD-dependent histone H3K9 deacetylase activity / NAD-dependent histone H4K16 deacetylase activity / SIRT1 negatively regulates rRNA expression / telomere tethering at nuclear periphery ... regulation of mating type switching / negative regulation of DNA amplification / RENT complex / regulation of DNA stability / NAD-dependent histone H3K14 deacetylase activity / establishment of protein-containing complex localization to telomere / NAD-dependent histone H3K9 deacetylase activity / NAD-dependent histone H4K16 deacetylase activity / SIRT1 negatively regulates rRNA expression / telomere tethering at nuclear periphery / negative regulation of DNA recombination / rDNA heterochromatin formation / protein acetyllysine N-acetyltransferase / chromatin silencing complex / NAD-dependent histone deacetylase activity / regulatory ncRNA-mediated gene silencing / sister chromatid cohesion / silent mating-type cassette heterochromatin formation / negative regulation of DNA replication / DNA replication origin binding / NAD+ binding / subtelomeric heterochromatin formation / heterochromatin / heterochromatin formation / double-strand break repair via nonhomologous end joining / chromatin organization / transferase activity / chromosome, telomeric region / nucleolus / nucleus / metal ion binding 類似検索 - 分子機能 NAD-dependent histone deacetylase Sir2, N-terminal / Protein of unknown function (DUF592) / SIR2/SIRT2 'Small Domain' / SIR2/SIRT2 'Small Domain' / Sirtuin, catalytic core small domain superfamily / : / Sirtuin family / Sir2 family / Sirtuin family, catalytic core domain / Sirtuin catalytic domain profile. ... NAD-dependent histone deacetylase Sir2, N-terminal / Protein of unknown function (DUF592) / SIR2/SIRT2 'Small Domain' / SIR2/SIRT2 'Small Domain' / Sirtuin, catalytic core small domain superfamily / : / Sirtuin family / Sir2 family / Sirtuin family, catalytic core domain / Sirtuin catalytic domain profile. / TPP-binding domain / DHS-like NAD/FAD-binding domain superfamily / Rossmann fold / 2-Layer Sandwich / 3-Layer(aba) Sandwich / Alpha Beta 類似検索 - ドメイン・相同性 NICOTINAMIDE / Chem-XYQ / NAD-dependent histone deacetylase SIR2 類似検索 - 構成要素生物種 Saccharomyces cerevisiae (パン酵母)手法 X線回折 / シンクロトロン / 単波長異常分散 / 解像度 : 1.85 Å 詳細データ登録者 Hall, B.E. / Ellenberger, T.E. 引用ジャーナル : To be Published タイトル : Autoregulation of the yeast Sir2 deacetylase by reaction and trapping of a pseudosubstrate motif in the active site著者 : Hall, B.E. / Buchberger, J.R. / Gerber, S.A. / Ambrosio, A.L.B. / Gygi, S.P. / Filman, D. / Moazed, D. / Ellenberger, T. 履歴 登録 2006年6月30日 登録サイト : RCSB / 処理サイト : RCSB改定 1.0 2008年4月8日 Provider : repository / タイプ : Initial release改定 1.1 2011年7月13日 Group : Advisory / Version format compliance改定 1.2 2017年10月18日 Group : Refinement description / カテゴリ : softwareItem : _software.classification / _software.contact_author ... _software.classification / _software.contact_author / _software.contact_author_email / _software.date / _software.language / _software.location / _software.name / _software.type / _software.version
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