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Yorodumi- PDB-2hir: SOLUTION STRUCTURE OF RECOMBINANT HIRUDIN AND THE LYS-47 (RIGHT A... -
+Open data
-Basic information
Entry | Database: PDB / ID: 2hir | ||||||
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Title | SOLUTION STRUCTURE OF RECOMBINANT HIRUDIN AND THE LYS-47 (RIGHT ARROW) GLU MUTANT. A NUCLEAR MAGNETIC RESONANCE AND HYBRID DISTANCE GEOMETRY-DYNAMICAL SIMULATED ANNEALING STUDY | ||||||
Components | HIRUDIN VARIANT-1 | ||||||
Keywords | COAGULATION INHIBITOR | ||||||
Function / homology | Function and homology information negative regulation of serine-type peptidase activity / serine-type endopeptidase inhibitor activity / extracellular space Similarity search - Function | ||||||
Biological species | Hirudo medicinalis (medicinal leech) | ||||||
Method | SOLUTION NMR | ||||||
Authors | Clore, G.M. / Gronenborn, A.M. | ||||||
Citation | Journal: Biochemistry / Year: 1989 Title: Solution structure of recombinant hirudin and the Lys-47----Glu mutant: a nuclear magnetic resonance and hybrid distance geometry-dynamical simulated annealing study. Authors: Folkers, P.J. / Clore, G.M. / Driscoll, P.C. / Dodt, J. / Kohler, S. / Gronenborn, A.M. | ||||||
History |
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-Structure visualization
Structure viewer | Molecule: MolmilJmol/JSmol |
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-Downloads & links
-Download
PDBx/mmCIF format | 2hir.cif.gz | 416 KB | Display | PDBx/mmCIF format |
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PDB format | pdb2hir.ent.gz | 357.2 KB | Display | PDB format |
PDBx/mmJSON format | 2hir.json.gz | Tree view | PDBx/mmJSON format | |
Others | Other downloads |
-Validation report
Arichive directory | https://data.pdbj.org/pub/pdb/validation_reports/hi/2hir ftp://data.pdbj.org/pub/pdb/validation_reports/hi/2hir | HTTPS FTP |
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-Related structure data
-Links
-Assembly
Deposited unit |
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1 |
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NMR ensembles |
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-Components
#1: Protein | Mass: 6973.505 Da / Num. of mol.: 1 Source method: isolated from a genetically manipulated source Source: (gene. exp.) Hirudo medicinalis (medicinal leech) / References: UniProt: P01050 |
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-Experimental details
-Experiment
Experiment | Method: SOLUTION NMR |
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-Sample preparation
Crystal grow | *PLUS Method: other / Details: NMR |
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-Processing
Software |
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NMR software | Name: X-PLOR / Developer: BRUNGER / Classification: refinement | ||||||||
Refinement | Software ordinal: 1 Details: ONLY RESIDUES 1-49 ARE WELL DEFINED. RESIDUES 50-65 FORM A DISORDERED C-TERMINAL TAIL. | ||||||||
NMR ensemble | Conformers submitted total number: 32 |