- PDB-2eqi: Solution structure of the SH3 domain from Phospholipase C, gamma 2 -
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基本情報
登録情報
データベース: PDB / ID: 2eqi
タイトル
Solution structure of the SH3 domain from Phospholipase C, gamma 2
要素
Phospholipase C, gamma 2
キーワード
IMMUNE SYSTEM / HYDROLASE / SH3 domain / Phospholipase C / gamma 2 / PLCg2 / Structural Genomics / NPPSFA / National Project on Protein Structural and Functional Analyses / RIKEN Structural Genomics/Proteomics Initiative / RSGI
機能・相同性
機能・相同性情報
Dectin-2 family / Toll Like Receptor 4 (TLR4) Cascade / follicular B cell differentiation / inositol trisphosphate biosynthetic process / regulation of calcineurin-NFAT signaling cascade / Synthesis of IP3 and IP4 in the cytosol / phosphatidylcholine phospholipase C activity / GPVI-mediated activation cascade / FCERI mediated MAPK activation / positive regulation of dendritic cell cytokine production ...Dectin-2 family / Toll Like Receptor 4 (TLR4) Cascade / follicular B cell differentiation / inositol trisphosphate biosynthetic process / regulation of calcineurin-NFAT signaling cascade / Synthesis of IP3 and IP4 in the cytosol / phosphatidylcholine phospholipase C activity / GPVI-mediated activation cascade / FCERI mediated MAPK activation / positive regulation of dendritic cell cytokine production / Generation of second messenger molecules / Role of phospholipids in phagocytosis / antifungal innate immune response / phosphoinositide phospholipase C / FCERI mediated Ca+2 mobilization / positive regulation of interleukin-23 production / phosphorylation-dependent protein binding / phospholipid catabolic process / cellular response to lectin / CLEC7A (Dectin-1) signaling / Antigen activates B Cell Receptor (BCR) leading to generation of second messengers / positive regulation of I-kappaB phosphorylation / response to yeast / positive regulation of cell cycle G1/S phase transition / phosphatidylinositol metabolic process / cell activation / positive regulation of neuroinflammatory response / positive regulation of phagocytosis, engulfment / phosphatidylinositol phospholipase C activity / phospholipase C activity / phosphatidylinositol biosynthetic process / macrophage activation involved in immune response / programmed cell death / negative regulation of programmed cell death / regulation of canonical NF-kappaB signal transduction / positive regulation of macrophage cytokine production / DAP12 signaling / positive regulation of reactive oxygen species biosynthetic process / positive regulation of NLRP3 inflammasome complex assembly / toll-like receptor signaling pathway / response to ATP / intracellular vesicle / positive regulation of epithelial cell migration / stimulatory C-type lectin receptor signaling pathway / phosphatidylinositol-mediated signaling / positive regulation of receptor internalization / positive regulation of interleukin-10 production / response to magnesium ion / regulation of lipid metabolic process / response to axon injury / positive regulation of type I interferon production / positive regulation of calcium-mediated signaling / release of sequestered calcium ion into cytosol / lipopolysaccharide-mediated signaling pathway / cellular response to calcium ion / positive regulation of interleukin-12 production / positive regulation of interleukin-2 production / phosphotyrosine residue binding / B cell differentiation / protein tyrosine kinase binding / calcium-mediated signaling / B cell receptor signaling pathway / positive regulation of DNA-binding transcription factor activity / ruffle membrane / positive regulation of interleukin-6 production / positive regulation of tumor necrosis factor production / positive regulation of peptidyl-tyrosine phosphorylation / positive regulation of NF-kappaB transcription factor activity / T cell receptor signaling pathway / positive regulation of cytosolic calcium ion concentration / scaffold protein binding / regulation of gene expression / response to lipopolysaccharide / positive regulation of MAPK cascade / intracellular signal transduction / membrane raft / positive regulation of gene expression / perinuclear region of cytoplasm / plasma membrane / cytosol 類似検索 - 分子機能
コンフォーマー選択の基準: structures with the least restraint violations, structures with the lowest energy, target function 計算したコンフォーマーの数: 100 / 登録したコンフォーマーの数: 20