- PDB-2dmk: The solution structure of the FN3 domain of human Midline 2 protein -
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Basic information
Entry
Database: PDB / ID: 2dmk
Title
The solution structure of the FN3 domain of human Midline 2 protein
Components
midline 2 isoform 2
Keywords
PROTEIN BINDING / Midline defect 2 / Tripartite motif protein 1 / Midin-2 / RING finger protein 60 / Structural Genomics / NPPSFA / National Project on Protein Structural and Functional Analyses / RIKEN Structural Genomics/Proteomics Initiative / RSGI
Function / homology
Function and homology information
suppression of viral release by host / protein localization to microtubule / negative regulation of viral entry into host cell / negative regulation of viral transcription / positive regulation of autophagy / phosphoprotein binding / RING-type E3 ubiquitin transferase / positive regulation of DNA-binding transcription factor activity / positive regulation of NF-kappaB transcription factor activity / transferase activity ...suppression of viral release by host / protein localization to microtubule / negative regulation of viral entry into host cell / negative regulation of viral transcription / positive regulation of autophagy / phosphoprotein binding / RING-type E3 ubiquitin transferase / positive regulation of DNA-binding transcription factor activity / positive regulation of NF-kappaB transcription factor activity / transferase activity / microtubule binding / positive regulation of canonical NF-kappaB signal transduction / microtubule / transcription coactivator activity / protein ubiquitination / innate immune response / enzyme binding / protein homodimerization activity / zinc ion binding / extracellular exosome / identical protein binding / cytoplasm Similarity search - Function
Probable E3 ubiquitin-protein ligase MID2 / TRIM1, PRY/SPRY domain / : / : / Midline-1, COS domain / TRIM C-terminal subgroup One Signature domain / COS domain / COS domain profile. / B-box, C-terminal / B-Box C-terminal domain ...Probable E3 ubiquitin-protein ligase MID2 / TRIM1, PRY/SPRY domain / : / : / Midline-1, COS domain / TRIM C-terminal subgroup One Signature domain / COS domain / COS domain profile. / B-box, C-terminal / B-Box C-terminal domain / Zinc finger, RING-type, eukaryotic / RING-type zinc-finger / Butyrophylin-like, SPRY domain / B-box zinc finger / B-Box-type zinc finger / B-box-type zinc finger / Zinc finger B-box type profile. / SPRY domain / B30.2/SPRY domain / B30.2/SPRY domain profile. / SPRY domain / B30.2/SPRY domain superfamily / Domain in SPla and the RYanodine Receptor. / Zinc finger, RING-type, conserved site / Zinc finger RING-type signature. / Ring finger / Fibronectin type 3 domain / Fibronectin type III / Fibronectin type III superfamily / Zinc finger RING-type profile. / Zinc finger, RING-type / Concanavalin A-like lectin/glucanase domain superfamily / Zinc finger, RING/FYVE/PHD-type / Immunoglobulins / Immunoglobulin-like fold / Immunoglobulin-like / Sandwich / Mainly Beta Similarity search - Domain/homology
Conformer selection criteria: target function, structures with the least restraint violations Conformers calculated total number: 100 / Conformers submitted total number: 20
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