- PDB-2da6: Solution structure of the homeobox domain of Hepatocyte nuclear f... -
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Basic information
Entry
Database: PDB / ID: 2da6
Title
Solution structure of the homeobox domain of Hepatocyte nuclear factor 1-beta (HNF-1beta)
Components
Hepatocyte nuclear factor 1-beta
Keywords
DNA BINDING PROTEIN / homeobox domain / three helices with the DNA binding helix-turn-helix motif / Structural Genomics / NPPSFA / National Project on Protein Structural and Functional Analyses / RIKEN Structural Genomics/Proteomics Initiative / RSGI
Function / homology
Function and homology information
regulation of pronephros size / pronephric nephron tubule development / ureteric bud elongation / hepatoblast differentiation / negative regulation of mesenchymal cell apoptotic process involved in mesonephric nephron morphogenesis / mesonephric duct formation / mesenchymal cell apoptotic process involved in metanephros development / regulation of branch elongation involved in ureteric bud branching / negative regulation of mesenchymal cell apoptotic process involved in metanephros development / pronephros development ...regulation of pronephros size / pronephric nephron tubule development / ureteric bud elongation / hepatoblast differentiation / negative regulation of mesenchymal cell apoptotic process involved in mesonephric nephron morphogenesis / mesonephric duct formation / mesenchymal cell apoptotic process involved in metanephros development / regulation of branch elongation involved in ureteric bud branching / negative regulation of mesenchymal cell apoptotic process involved in metanephros development / pronephros development / Regulation of gene expression in early pancreatic precursor cells / inner cell mass cell differentiation / Nephron development / endodermal cell fate specification / genitalia development / embryonic digestive tract morphogenesis / hindbrain development / endocrine pancreas development / regulation of Wnt signaling pathway / pancreas development / Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells / insulin secretion / anterior/posterior pattern specification / branching morphogenesis of an epithelial tube / positive regulation of transcription initiation by RNA polymerase II / response to glucose / Notch signaling pathway / epithelial cell proliferation / kidney development / transcription coregulator binding / transcription regulator complex / DNA-binding transcription factor activity, RNA polymerase II-specific / RNA polymerase II cis-regulatory region sequence-specific DNA binding / DNA-binding transcription factor activity / intracellular membrane-bounded organelle / positive regulation of gene expression / chromatin / regulation of transcription by RNA polymerase II / positive regulation of DNA-templated transcription / negative regulation of transcription by RNA polymerase II / protein homodimerization activity / DNA binding / nucleoplasm / identical protein binding / nucleus Similarity search - Function
Conformer selection criteria: target function, structures with the lowest energy, structures with the least restraint violations Conformers calculated total number: 100 / Conformers submitted total number: 20
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