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データを開く
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基本情報
| 登録情報 | データベース: PDB / ID: 2cyk | ||||||
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| タイトル | ASPECTS OF RECEPTOR BINDING AND SIGNALLING OF INTERLEUKIN-4 INVESTIGATED BY SITE-DIRECTED MUTAGENESIS AND NMR SPECTROSCOPY | ||||||
要素 | INTERLEUKIN-4 | ||||||
キーワード | CYTOKINE | ||||||
| 機能・相同性 | 機能・相同性情報interleukin-4 receptor binding / positive regulation of isotype switching to IgE isotypes / negative regulation of complement-dependent cytotoxicity / positive regulation of cellular respiration / Interleukin-18 signaling / regulation of isotype switching / negative regulation of neuroinflammatory response / negative regulation of epithelial cell migration / positive regulation of T-helper 2 cell cytokine production / dendritic cell differentiation ...interleukin-4 receptor binding / positive regulation of isotype switching to IgE isotypes / negative regulation of complement-dependent cytotoxicity / positive regulation of cellular respiration / Interleukin-18 signaling / regulation of isotype switching / negative regulation of neuroinflammatory response / negative regulation of epithelial cell migration / positive regulation of T-helper 2 cell cytokine production / dendritic cell differentiation / interleukin-4-mediated signaling pathway / neuroinflammatory response / positive regulation of isotype switching to IgG isotypes / positive regulation of interleukin-13 production / macrophage activation / positive regulation of amyloid-beta clearance / myeloid dendritic cell differentiation / positive regulation of MHC class II biosynthetic process / type 2 immune response / negative regulation of cellular response to transforming growth factor beta stimulus / positive regulation of T cell differentiation / negative regulation of osteoclast differentiation / positive regulation of ATP biosynthetic process / positive regulation of interleukin-10 production / positive regulation of macroautophagy / negative regulation of tumor necrosis factor production / cell surface receptor signaling pathway via JAK-STAT / regulation of immune response / negative regulation of endothelial cell apoptotic process / cholesterol metabolic process / positive regulation of B cell proliferation / positive regulation of T cell proliferation / T cell activation / B cell differentiation / cytokine activity / growth factor activity / positive regulation of receptor-mediated endocytosis / negative regulation of inflammatory response / positive regulation of cold-induced thermogenesis / Interleukin-4 and Interleukin-13 signaling / immune response / positive regulation of cell migration / negative regulation of DNA-templated transcription / positive regulation of cell population proliferation / positive regulation of gene expression / negative regulation of apoptotic process / positive regulation of DNA-templated transcription / negative regulation of transcription by RNA polymerase II / positive regulation of transcription by RNA polymerase II / extracellular space / extracellular region 類似検索 - 分子機能 | ||||||
| 生物種 | Homo sapiens (ヒト) | ||||||
| 手法 | 溶液NMR | ||||||
データ登録者 | Mueller, T. / Sebald, W. / Oschkinat, H. | ||||||
引用 | ジャーナル: J.Mol.Biol. / 年: 1994タイトル: Aspects of receptor binding and signalling of interleukin-4 investigated by site-directed mutagenesis and NMR spectroscopy. 著者: Muller, T. / Dieckmann, T. / Sebald, W. / Oschkinat, H. | ||||||
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構造の表示
| 構造ビューア | 分子: Molmil Jmol/JSmol |
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ダウンロードとリンク
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ダウンロード
| PDBx/mmCIF形式 | 2cyk.cif.gz | 57.3 KB | 表示 | PDBx/mmCIF形式 |
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| PDB形式 | pdb2cyk.ent.gz | 42.9 KB | 表示 | PDB形式 |
| PDBx/mmJSON形式 | 2cyk.json.gz | ツリー表示 | PDBx/mmJSON形式 | |
| その他 | その他のダウンロード |
-検証レポート
| 文書・要旨 | 2cyk_validation.pdf.gz | 243.1 KB | 表示 | wwPDB検証レポート |
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| 文書・詳細版 | 2cyk_full_validation.pdf.gz | 242.8 KB | 表示 | |
| XML形式データ | 2cyk_validation.xml.gz | 4.1 KB | 表示 | |
| CIF形式データ | 2cyk_validation.cif.gz | 5.3 KB | 表示 | |
| アーカイブディレクトリ | https://data.pdbj.org/pub/pdb/validation_reports/cy/2cyk ftp://data.pdbj.org/pub/pdb/validation_reports/cy/2cyk | HTTPS FTP |
-関連構造データ
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リンク
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集合体
| 登録構造単位 | ![]()
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| 1 |
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| NMR アンサンブル |
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要素
| #1: タンパク質 | 分子量: 14989.248 Da / 分子数: 1 / 由来タイプ: 組換発現 / 由来: (組換発現) Homo sapiens (ヒト) / 参照: UniProt: P05112 |
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| Has protein modification | Y |
-実験情報
-実験
| 実験 | 手法: 溶液NMR |
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解析
| ソフトウェア |
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| NMR software | 名称: X-PLOR / 開発者: BRUNGER / 分類: 精密化 | ||||||||
| NMRアンサンブル | 登録したコンフォーマーの数: 1 |
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万見について




Homo sapiens (ヒト)
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X-PLOR