Entry Database : PDB / ID : 2ckl Structure visualization Downloads & linksTitle Ring1b-Bmi1 E3 catalytic domain structure ComponentsPOLYCOMB GROUP RING FINGER PROTEIN 4 UBIQUITIN LIGASE PROTEIN RING2 DetailsKeywords TRANSCRIPTION / BMI1 / LIGASE / RING1B / POLYCOMB / E3-LIGASE / NUCLEAR PROTEIN / CHROMOSOMAL PROTEIN / TRANSCRIPTION REGULATION / METAL-BINDING / PROTO-ONCOGENE / CHROMATIN REGULATOR / UBL CONJUGATION PATHWAY / REPRESSOR / ZINC-FINGER / RING DOMAIN / TRANSCRIPTION REGULATION COMPLEXFunction / homology Function and homology informationFunction Domain/homology Component
: / cellular process / Transcriptional Regulation by E2F6 / : / : / regulation of adaxial/abaxial pattern formation / SUMOylation of RNA binding proteins / Regulation of PTEN gene transcription / SUMOylation of DNA damage response and repair proteins / RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known ... : / cellular process / Transcriptional Regulation by E2F6 / : / : / regulation of adaxial/abaxial pattern formation / SUMOylation of RNA binding proteins / Regulation of PTEN gene transcription / SUMOylation of DNA damage response and repair proteins / RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known / : / heterochromatin formation => GO:0031507 / SUMOylation of transcription cofactors / SUMOylation of chromatin organization proteins / : / RING-like zinc finger domain binding / sex chromatin / PRC1 complex / rostrocaudal neural tube patterning / hematopoietic stem cell homeostasis / ubiquitin-protein transferase activator activity / somatic stem cell division / embryonic skeletal system morphogenesis / embryonic skeletal system development / PcG protein complex / positive regulation of immature T cell proliferation in thymus / gastrulation with mouth forming second / positive regulation of ubiquitin-protein transferase activity / anterior/posterior axis specification / negative regulation of gene expression, epigenetic / germ cell development / negative regulation of apoptotic signaling pathway / humoral immune response / MLL1 complex / cellular response to interleukin-1 / heterochromatin / ubiquitin ligase complex / positive regulation of B cell proliferation / cellular response to dexamethasone stimulus / skeletal system development / promoter-specific chromatin binding / euchromatin / RING-type E3 ubiquitin transferase / negative regulation of DNA-binding transcription factor activity / brain development / ubiquitin protein ligase activity / mitotic cell cycle / gene expression / in utero embryonic development / sequence-specific DNA binding / nuclear body / RNA polymerase II cis-regulatory region sequence-specific DNA binding / chromatin binding / negative regulation of transcription by RNA polymerase II / zinc ion binding / nucleoplasm / nucleus / cytoplasm Similarity search - Function E3 ubiquitin-protein ligase RING2 / E3 ubiquitin-protein ligase RING1/RING2 / RAWUL domain / RAWUL domain RING finger- and WD40-associated ubiquitin-like / Zinc finger, C3HC4 type (RING finger) / Zinc/RING finger domain, C3HC4 (zinc finger) / Herpes Virus-1 / Zinc finger, RING-type, conserved site / Zinc finger RING-type signature. / Ring finger ... E3 ubiquitin-protein ligase RING2 / E3 ubiquitin-protein ligase RING1/RING2 / RAWUL domain / RAWUL domain RING finger- and WD40-associated ubiquitin-like / Zinc finger, C3HC4 type (RING finger) / Zinc/RING finger domain, C3HC4 (zinc finger) / Herpes Virus-1 / Zinc finger, RING-type, conserved site / Zinc finger RING-type signature. / Ring finger / Zinc finger RING-type profile. / Zinc finger, RING-type / Zinc finger, RING/FYVE/PHD-type / 2-Layer Sandwich / Alpha Beta Similarity search - Domain/homologyBiological species MUS MUSCULUS (house mouse)Method X-RAY DIFFRACTION / SYNCHROTRON / MAD / Resolution : 2 Å DetailsAuthors Buchwald, G. / van der Stoop, P. / Weichenrieder, O. / Perrakis, A. / van Lohuizen, M. / Sixma, T.K. CitationJournal : Embo J. / Year : 2006Title : Structure and E3-Ligase Activity of the Ring-Ring Complex of Polycomb Proteins Bmi1 and Ring1B.Authors : Buchwald, G. / Van Der Stoop, P. / Weichenrieder, O. / Perrakis, A. / Van Lohuizen, M. / Sixma, T.K. History Deposition Apr 20, 2006 Deposition site : PDBE / Processing site : PDBERevision 1.0 May 11, 2006 Provider : repository / Type : Initial releaseRevision 1.1 Jul 13, 2011 Group : Advisory / Version format complianceRevision 1.2 May 8, 2024 Group : Data collection / Database references ... Data collection / Database references / Derived calculations / Other Category : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / database_2 / pdbx_database_status / pdbx_struct_conn_angle / struct_conn Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession ... _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _pdbx_database_status.status_code_sf / _pdbx_struct_conn_angle.ptnr1_auth_comp_id / _pdbx_struct_conn_angle.ptnr1_auth_seq_id / _pdbx_struct_conn_angle.ptnr1_label_atom_id / _pdbx_struct_conn_angle.ptnr1_label_comp_id / _pdbx_struct_conn_angle.ptnr1_label_seq_id / _pdbx_struct_conn_angle.ptnr2_auth_seq_id / _pdbx_struct_conn_angle.ptnr2_label_asym_id / _pdbx_struct_conn_angle.ptnr3_auth_comp_id / _pdbx_struct_conn_angle.ptnr3_auth_seq_id / _pdbx_struct_conn_angle.ptnr3_label_atom_id / _pdbx_struct_conn_angle.ptnr3_label_comp_id / _pdbx_struct_conn_angle.ptnr3_label_seq_id / _pdbx_struct_conn_angle.value / _struct_conn.pdbx_dist_value / _struct_conn.ptnr1_auth_comp_id / _struct_conn.ptnr1_auth_seq_id / _struct_conn.ptnr1_label_asym_id / _struct_conn.ptnr1_label_atom_id / _struct_conn.ptnr1_label_comp_id / _struct_conn.ptnr1_label_seq_id / _struct_conn.ptnr2_auth_comp_id / _struct_conn.ptnr2_auth_seq_id / _struct_conn.ptnr2_label_asym_id / _struct_conn.ptnr2_label_atom_id / _struct_conn.ptnr2_label_comp_id / _struct_conn.ptnr2_label_seq_id
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