登録情報 データベース : PDB / ID : 2blb 構造の表示 ダウンロードとリンクタイトル X-ray crystal structure of Plasmodium vivax dihydrofolate reductase in complex with pyrimethamine and its derivative 要素DIHYDROFOLATE REDUCTASE-THYMIDYLATE SYNTHASE 詳細 キーワード OXIDOREDUCTASE / DIHYDROFOLATE REDUCTASE / PLAMODIUM VIVAX / PYRIMETHAMINE / MALARIA / DRUG RESISTANCE機能・相同性 機能・相同性情報分子機能 ドメイン・相同性 構成要素
thymidylate synthase / thymidylate synthase activity / dTMP biosynthetic process / glycine biosynthetic process / dihydrofolate reductase / dihydrofolate reductase activity / tetrahydrofolate biosynthetic process / one-carbon metabolic process / NADP binding / methylation ... thymidylate synthase / thymidylate synthase activity / dTMP biosynthetic process / glycine biosynthetic process / dihydrofolate reductase / dihydrofolate reductase activity / tetrahydrofolate biosynthetic process / one-carbon metabolic process / NADP binding / methylation / mitochondrion / cytosol 類似検索 - 分子機能 Bifunctional dihydrofolate reductase/thymidylate synthase / Thymidylate synthase/dCMP hydroxymethylase / Thymidylate synthase, active site / Thymidylate synthase active site. / Thymidylate synthase / Thymidylate synthase/dCMP hydroxymethylase domain / Thymidylate synthase/dCMP hydroxymethylase superfamily / Thymidylate synthase / Dihydrofolate Reductase, subunit A / Dihydrofolate Reductase, subunit A ... Bifunctional dihydrofolate reductase/thymidylate synthase / Thymidylate synthase/dCMP hydroxymethylase / Thymidylate synthase, active site / Thymidylate synthase active site. / Thymidylate synthase / Thymidylate synthase/dCMP hydroxymethylase domain / Thymidylate synthase/dCMP hydroxymethylase superfamily / Thymidylate synthase / Dihydrofolate Reductase, subunit A / Dihydrofolate Reductase, subunit A / Dihydrofolate reductase / Dihydrofolate reductase conserved site / Dihydrofolate reductase (DHFR) domain signature. / Dihydrofolate reductase domain / Dihydrofolate reductase / Dihydrofolate reductase (DHFR) domain profile. / Dihydrofolate reductase-like domain superfamily / 3-Layer(aba) Sandwich / Alpha Beta 類似検索 - ドメイン・相同性 6-ETHYL-5-PHENYLPYRIMIDINE-2,4-DIAMINE / Chem-NDP / Bifunctional dihydrofolate reductase-thymidylate synthase / Bifunctional dihydrofolate reductase-thymidylate synthase 類似検索 - 構成要素生物種 PLASMODIUM VIVAX (マラリア 病原虫)手法 X線回折 / 分子置換 / 解像度 : 3 Å 詳細データ登録者 Kongsaeree, P. / Khongsuk, P. / Leartsakulpanich, U. / Chitnumsub, P. / Tarnchompoo, B. / Walkinshaw, M.D. / Yuthavong, Y. 引用ジャーナル : Proc.Natl.Acad.Sci.USA / 年 : 2005タイトル : Crystal Structure of Dihydrofolate Reductase from Plasmodium Vivax: Pyrimethamine Displacement Linked with Mutation-Induced Resistance.著者 : Kongsaeree, P. / Khongsuk, P. / Leartsakulpanich, U. / Chitnumsub, P. / Tarnchompoo, B. / Walkinshaw, M.D. / Yuthavong, Y. 履歴 登録 2005年3月3日 登録サイト : PDBE / 処理サイト : PDBE改定 1.0 2005年9月7日 Provider : repository / タイプ : Initial release改定 1.1 2011年5月8日 Group : Version format compliance改定 1.2 2011年7月13日 Group : Version format compliance改定 1.3 2017年6月28日 Group : Data collection / カテゴリ : diffrn_source / Item : _diffrn_source.type改定 1.4 2024年5月8日 Group : Data collection / Database references / Otherカテゴリ : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / database_2 / pdbx_database_status Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _pdbx_database_status.status_code_sf
すべて表示 表示を減らす Remark 700 SHEET THE SHEET STRUCTURE OF THIS MOLECULE IS BIFURCATED. IN ORDER TO REPRESENT THIS FEATURE IN ... SHEET THE SHEET STRUCTURE OF THIS MOLECULE IS BIFURCATED. IN ORDER TO REPRESENT THIS FEATURE IN THE SHEET RECORDS BELOW, TWO SHEETS ARE DEFINED.