登録情報 | データベース: PDB / ID: 2azt |
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タイトル | Crystal structure of H176N mutant of human Glycine N-Methyltransferase |
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要素 | Glycine N-methyltransferase |
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キーワード | TRANSFERASE / glycine N-methyltransferase |
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機能・相同性 | 機能・相同性情報
glycine N-methyltransferase / sarcosine metabolic process / glycine N-methyltransferase activity / methionine metabolic process / Glyoxylate metabolism and glycine degradation / Metabolism of ingested SeMet, Sec, MeSec into H2Se / S-adenosylhomocysteine metabolic process / S-adenosylmethionine metabolic process / Developmental Lineage of Pancreatic Acinar Cells / S-adenosyl-L-methionine binding ...glycine N-methyltransferase / sarcosine metabolic process / glycine N-methyltransferase activity / methionine metabolic process / Glyoxylate metabolism and glycine degradation / Metabolism of ingested SeMet, Sec, MeSec into H2Se / S-adenosylhomocysteine metabolic process / S-adenosylmethionine metabolic process / Developmental Lineage of Pancreatic Acinar Cells / S-adenosyl-L-methionine binding / folic acid binding / regulation of gluconeogenesis / glycogen metabolic process / glycine binding / one-carbon metabolic process / methylation / protein homotetramerization / identical protein binding / cytosol類似検索 - 分子機能 Glycine N-methyltransferase; chain A, domain 1 / Glycine N-methyltransferase, chain A, domain 1 / Glycine/Sarcosine N-methyltransferase / Glycine N-methyltransferase (EC 2.1.1.20 and EC 2.1.1.156) family profile. / Methyltransferase domain 25 / Methyltransferase domain / Vaccinia Virus protein VP39 / S-adenosyl-L-methionine-dependent methyltransferase superfamily / Rossmann fold / 2-Layer Sandwich ...Glycine N-methyltransferase; chain A, domain 1 / Glycine N-methyltransferase, chain A, domain 1 / Glycine/Sarcosine N-methyltransferase / Glycine N-methyltransferase (EC 2.1.1.20 and EC 2.1.1.156) family profile. / Methyltransferase domain 25 / Methyltransferase domain / Vaccinia Virus protein VP39 / S-adenosyl-L-methionine-dependent methyltransferase superfamily / Rossmann fold / 2-Layer Sandwich / 3-Layer(aba) Sandwich / Alpha Beta類似検索 - ドメイン・相同性 BETA-MERCAPTOETHANOL / CITRIC ACID / Glycine N-methyltransferase類似検索 - 構成要素 |
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生物種 | Homo sapiens (ヒト) |
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手法 | X線回折 / 分子置換 / 解像度: 2.7 Å |
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データ登録者 | Luka, Z. / Pakhomova, S. / Luka, Y. / Newcomer, M.E. / Wagner, C. |
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引用 | ジャーナル: Protein Sci. / 年: 2007 タイトル: Destabilization of human glycine N-methyltransferase by H176N mutation. 著者: Luka, Z. / Pakhomova, S. / Luka, Y. / Newcomer, M.E. / Wagner, C. |
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履歴 | 登録 | 2005年9月12日 | 登録サイト: RCSB / 処理サイト: RCSB |
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改定 1.0 | 2006年9月26日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2007年10月16日 | Group: Version format compliance |
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改定 1.2 | 2011年7月13日 | Group: Derived calculations / Version format compliance |
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改定 1.3 | 2021年10月20日 | Group: Database references / Derived calculations カテゴリ: database_2 / struct_conn ...database_2 / struct_conn / struct_ref_seq_dif / struct_site Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession ..._database_2.pdbx_DOI / _database_2.pdbx_database_accession / _struct_conn.pdbx_leaving_atom_flag / _struct_conn.ptnr1_auth_comp_id / _struct_conn.ptnr1_auth_seq_id / _struct_conn.ptnr1_label_asym_id / _struct_conn.ptnr1_label_atom_id / _struct_conn.ptnr1_label_comp_id / _struct_conn.ptnr1_label_seq_id / _struct_conn.ptnr2_auth_comp_id / _struct_conn.ptnr2_auth_seq_id / _struct_conn.ptnr2_label_asym_id / _struct_conn.ptnr2_label_atom_id / _struct_conn.ptnr2_label_comp_id / _struct_conn.ptnr2_label_seq_id / _struct_ref_seq_dif.details / _struct_site.pdbx_auth_asym_id / _struct_site.pdbx_auth_comp_id / _struct_site.pdbx_auth_seq_id |
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改定 1.4 | 2023年8月23日 | Group: Data collection / Refinement description カテゴリ: chem_comp_atom / chem_comp_bond / pdbx_initial_refinement_model |
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