登録情報 データベース : PDB / ID : 2aga 構造の表示 ダウンロードとリンクタイトル De-ubiquitinating function of ataxin-3: insights from the solution structure of the Josephin domain 要素Machado-Joseph disease protein 1 詳細 キーワード TRANSCRIPTION / Polyglutamine / ubiquitin / UIM / ataxia / VCP/p97機能・相同性 機能・相同性情報分子機能 ドメイン・相同性 構成要素
protein localization to cytosolic proteasome complex / regulation of cell-substrate adhesion / positive regulation of ERAD pathway / monoubiquitinated protein deubiquitination / intermediate filament cytoskeleton organization / protein K48-linked deubiquitination / nuclear inclusion body / positive regulation of ubiquitin-dependent protein catabolic process / protein K63-linked deubiquitination / cellular response to misfolded protein ... protein localization to cytosolic proteasome complex / regulation of cell-substrate adhesion / positive regulation of ERAD pathway / monoubiquitinated protein deubiquitination / intermediate filament cytoskeleton organization / protein K48-linked deubiquitination / nuclear inclusion body / positive regulation of ubiquitin-dependent protein catabolic process / protein K63-linked deubiquitination / cellular response to misfolded protein / K48-linked deubiquitinase activity / K63-linked deubiquitinase activity / protein quality control for misfolded or incompletely synthesized proteins / FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes / negative regulation of TORC1 signaling / cellular response to amino acid starvation / Josephin domain DUBs / mitochondrial membrane / nucleotide-excision repair / nuclear matrix / microtubule cytoskeleton organization / nervous system development / cellular response to heat / ATPase binding / actin cytoskeleton organization / ubiquitin-dependent protein catabolic process / chemical synaptic transmission / proteasome-mediated ubiquitin-dependent protein catabolic process / ubiquitinyl hydrolase 1 / cysteine-type deubiquitinase activity / mitochondrial matrix / lysosomal membrane / ubiquitin protein ligase binding / synapse / nucleolus / nucleoplasm / identical protein binding / nucleus / plasma membrane / cytoplasm / cytosol 類似検索 - 分子機能 Cathepsin B; Chain A - #40 / Unstructured region C-term to UIM in Ataxin3 / Machado-Joseph disease protein / Josephin domain / Josephin / Josephin domain profile. / Josephin / Ubiquitin interaction motif / S15/NS1, RNA-binding / Ubiquitin-interacting motif. ... Cathepsin B; Chain A - #40 / Unstructured region C-term to UIM in Ataxin3 / Machado-Joseph disease protein / Josephin domain / Josephin / Josephin domain profile. / Josephin / Ubiquitin interaction motif / S15/NS1, RNA-binding / Ubiquitin-interacting motif. / Ubiquitin interacting motif / Ubiquitin-interacting motif (UIM) domain profile. / Cathepsin B; Chain A / Helix Hairpins / Alpha-Beta Complex / Orthogonal Bundle / Mainly Alpha / Alpha Beta 類似検索 - ドメイン・相同性生物種 Homo sapiens (ヒト)手法 溶液NMR / simulated annealing 詳細データ登録者 Mao, Y. / Senic-Matuglia, F. / Di Fiore, P. / Polo, S. / Hodsdon, M.E. / De Camilli, P. 引用ジャーナル : Proc.Natl.Acad.Sci.Usa / 年 : 2005タイトル : Deubiquitinating function of ataxin-3: insights from the solution structure of the Josephin domain.著者 : Mao, Y. / Senic-Matuglia, F. / Di Fiore, P.P. / Polo, S. / Hodsdon, M.E. / De Camilli, P. 履歴 登録 2005年7月26日 登録サイト : RCSB / 処理サイト : RCSB改定 1.0 2005年8月30日 Provider : repository / タイプ : Initial release改定 1.1 2008年4月30日 Group : Version format compliance改定 1.2 2011年7月13日 Group : Version format compliance改定 1.3 2020年2月5日 Group : Data collection / Database references ... Data collection / Database references / Derived calculations / Other カテゴリ : database_2 / pdbx_database_status ... database_2 / pdbx_database_status / pdbx_nmr_software / pdbx_struct_assembly / pdbx_struct_oper_list / struct_ref_seq_dif Item : _pdbx_database_status.status_code_cs / _pdbx_nmr_software.name / _struct_ref_seq_dif.details改定 1.4 2023年6月14日 Group : Database references / Other / カテゴリ : database_2 / pdbx_database_statusItem : _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _pdbx_database_status.status_code_nmr_data改定 1.5 2024年5月8日 Group : Data collection / Database references / カテゴリ : chem_comp_atom / chem_comp_bond / database_2 / Item : _database_2.pdbx_DOI
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