Mass: 29772.422 Da / Num. of mol.: 2 / Fragment: Thrombin heavy chain / Source method: isolated from a natural source / Source: (natural) Bos taurus (cattle) / References: UniProt: P00735, thrombin
#3: Protein
Staphylocoagulase
Mass: 38541.992 Da / Num. of mol.: 2 / Fragment: active fragment 1-329 Source method: isolated from a genetically manipulated source Source: (gene. exp.) Staphylococcus aureus (bacteria) / Production host: Escherichia coli (E. coli) / References: UniProt: P17855
Mass: 22.990 Da / Num. of mol.: 2 / Source method: obtained synthetically / Formula: Na
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Details
Nonpolymer details
THE INHIBITOR IS COVALENTLY CONNECTED TO ACTIVE_SITE RESIDUES: 1) VIA A HEMIKETAL GROUP TO OG SER ...THE INHIBITOR IS COVALENTLY CONNECTED TO ACTIVE_SITE RESIDUES: 1) VIA A HEMIKETAL GROUP TO OG SER 195 IN CHAINS B AND F, 2) VIA A METHYLENE GROUP TO NE2 HIS 57 IN CHAINS B AND F.
Sequence details
THIS DIVERGENCE OF GLY FROM THE REPORTED SEQUENCE, PERHAPS ADDING THAT THIS VARIATION IS IRRELEVANT ...THIS DIVERGENCE OF GLY FROM THE REPORTED SEQUENCE, PERHAPS ADDING THAT THIS VARIATION IS IRRELEVANT FOR (PRO)THROMBIN BINDING, WHICH IS AN IMPORTANT POINT OF THIS ENTRY.
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Experimental details
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Experiment
Experiment
Method: X-RAY DIFFRACTION / Number of used crystals: 1
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Sample preparation
Crystal
Density Matthews: 3.4 Å3/Da / Density % sol: 62.4 %
Crystal grow
Temperature: 298 K / Method: vapor diffusion, sitting drop / pH: 6.5 Details: 0.1M IMIDAZOLE, 0.2M AMMONIUM FORMATE, 12% POLYETHYLENE GLYCOL 4000, pH 6.5, VAPOR DIFFUSION, SITTING DROP, temperature 298K
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