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Yorodumi- PDB-1yuf: TYPE ALPHA TRANSFORMING GROWTH FACTOR, NMR, 16 MODELS WITHOUT ENE... -
+Open data
-Basic information
Entry | Database: PDB / ID: 1yuf | ||||||
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Title | TYPE ALPHA TRANSFORMING GROWTH FACTOR, NMR, 16 MODELS WITHOUT ENERGY MINIMIZATION | ||||||
Components | TRANSFORMING GROWTH FACTOR ALPHA | ||||||
Keywords | GROWTH FACTOR / EGF-LIKE DOMAIN STRUCTURE | ||||||
Function / homology | Function and homology information hepatocyte proliferation / Cargo concentration in the ER / Inhibition of Signaling by Overexpressed EGFR / COPII-mediated vesicle transport / EGFR interacts with phospholipase C-gamma / ERBB2-EGFR signaling pathway / epidermal growth factor receptor binding / Signaling by EGFR / transmembrane receptor protein tyrosine kinase activator activity / positive regulation of cell division ...hepatocyte proliferation / Cargo concentration in the ER / Inhibition of Signaling by Overexpressed EGFR / COPII-mediated vesicle transport / EGFR interacts with phospholipase C-gamma / ERBB2-EGFR signaling pathway / epidermal growth factor receptor binding / Signaling by EGFR / transmembrane receptor protein tyrosine kinase activator activity / positive regulation of cell division / Estrogen-dependent nuclear events downstream of ESR-membrane signaling / mammary gland alveolus development / GAB1 signalosome / GRB2 events in EGFR signaling / SHC1 events in EGFR signaling / TFAP2 (AP-2) family regulates transcription of growth factors and their receptors / endoplasmic reticulum-Golgi intermediate compartment membrane / positive regulation of mitotic nuclear division / positive regulation of epithelial cell proliferation / EGFR downregulation / clathrin-coated endocytic vesicle membrane / growth factor activity / epidermal growth factor receptor signaling pathway / ER to Golgi transport vesicle membrane / Constitutive Signaling by Aberrant PI3K in Cancer / positive regulation of peptidyl-tyrosine phosphorylation / Cargo recognition for clathrin-mediated endocytosis / PIP3 activates AKT signaling / Clathrin-mediated endocytosis / PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling / cytoplasmic vesicle / RAF/MAP kinase cascade / basolateral plasma membrane / angiogenesis / Estrogen-dependent gene expression / Extra-nuclear estrogen signaling / positive regulation of MAPK cascade / receptor ligand activity / intracellular signal transduction / positive regulation of cell population proliferation / endoplasmic reticulum membrane / perinuclear region of cytoplasm / cell surface / extracellular space / extracellular region / plasma membrane Similarity search - Function | ||||||
Biological species | Homo sapiens (human) | ||||||
Method | SOLUTION NMR | ||||||
Authors | Moy, F.J. / Montelione, G.T. / Scheraga, H.A. | ||||||
Citation | Journal: Biochemistry / Year: 1993 Title: Solution structure of human type-alpha transforming growth factor determined by heteronuclear NMR spectroscopy and refined by energy minimization with restraints. Authors: Moy, F.J. / Li, Y.C. / Rauenbuehler, P. / Winkler, M.E. / Scheraga, H.A. / Montelione, G.T. #1: Journal: J.Biomol.NMR / Year: 1995 Title: Crankshaft Motions of the Polypeptide Backbone in Molecular Dynamics Simulations of Human Type-Alpha Transforming Growth Factor Authors: Fadel, A.R. / Jin, D.Q. / Montelione, G.T. / Levy, R.M. #2: Journal: Biochemistry / Year: 1995 Title: Human Type-Alpha Transforming Growth Factor Undergoes Slow Conformational Exchange between Multiple Backbone Conformations as Characterized by Nitrogen-15 Relaxation Measurements Authors: Li, Y.C. / Montelione, G.T. #3: Journal: Proc.Natl.Acad.Sci.USA / Year: 1989 Title: Sequence-Specific 1H-NMR Assignments and Identification of Two Small Antiparallel Beta-Sheets in the Solution Structure of Recombinant Human Transforming Growth Factor Alpha Authors: Montelione, G.T. / Winkler, M.E. / Burton, L.E. / Rinderknecht, E. / Sporn, M.B. / Wagner, G. | ||||||
History |
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-Structure visualization
Structure viewer | Molecule: MolmilJmol/JSmol |
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-Downloads & links
-Download
PDBx/mmCIF format | 1yuf.cif.gz | 229.2 KB | Display | PDBx/mmCIF format |
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PDB format | pdb1yuf.ent.gz | 195.8 KB | Display | PDB format |
PDBx/mmJSON format | 1yuf.json.gz | Tree view | PDBx/mmJSON format | |
Others | Other downloads |
-Validation report
Arichive directory | https://data.pdbj.org/pub/pdb/validation_reports/yu/1yuf ftp://data.pdbj.org/pub/pdb/validation_reports/yu/1yuf | HTTPS FTP |
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-Related structure data
-Links
-Assembly
Deposited unit |
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1 |
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NMR ensembles |
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-Components
#1: Protein/peptide | Mass: 5560.246 Da / Num. of mol.: 1 Source method: isolated from a genetically manipulated source Source: (gene. exp.) Homo sapiens (human) / Gene: HUMAN TGF-ALPHA 1YUF / Plasmid: PTE5 / Gene (production host): HUMAN TGF-ALPHA 1YUF / Production host: Escherichia coli (E. coli) / References: UniProt: P01135 |
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-Experimental details
-Experiment
Experiment | Method: SOLUTION NMR |
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-Sample preparation
Crystal grow | *PLUS Method: other / Details: NMR |
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-Processing
NMR software | Name: DISMAN / Developer: BRAUN,GO / Classification: refinement |
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NMR ensemble | Conformers submitted total number: 16 |