Entry Database : PDB / ID : 1wmh Structure visualization Downloads & linksTitle Crystal structure of a PB1 domain complex of Protein kinase c iota and Par6 alpha ComponentsPartitioning defective-6 homolog alpha Protein kinase C, iota type DetailsKeywords Transferase/CELL CYCLE / KINASE / PB1 DOMAIN / OPCA MOTIF / aPKC / Par6 / cell polarity / Transferase-CELL CYCLE COMPLEXFunction / homology Function and homology informationFunction Domain/homology Component
small GTPase binding => GO:0031267 / Golgi vesicle budding / PAR polarity complex / regulation of cellular localization / cell-cell junction maintenance / Tight junction interactions / establishment of apical/basal cell polarity / protein kinase C / negative regulation of glial cell apoptotic process / eye photoreceptor cell development ... small GTPase binding => GO:0031267 / Golgi vesicle budding / PAR polarity complex / regulation of cellular localization / cell-cell junction maintenance / Tight junction interactions / establishment of apical/basal cell polarity / protein kinase C / negative regulation of glial cell apoptotic process / eye photoreceptor cell development / diacylglycerol-dependent serine/threonine kinase activity / GTP-dependent protein binding / positive regulation of protein localization to centrosome / Schmidt-Lanterman incisure / cellular response to chemical stress / bicellular tight junction assembly / membrane organization / positive regulation of endothelial cell apoptotic process / cell-cell junction organization / tight junction / establishment or maintenance of epithelial cell apical/basal polarity / protein targeting to membrane / centrosome cycle / Wnt signaling pathway, planar cell polarity pathway / establishment or maintenance of cell polarity / intercellular bridge / positive regulation of Notch signaling pathway / cell leading edge / regulation of postsynaptic membrane neurotransmitter receptor levels / brush border / transcription factor binding / centriolar satellite / bicellular tight junction / vesicle-mediated transport / positive regulation of glial cell proliferation / ruffle / cytoskeleton organization / p75NTR recruits signalling complexes / viral process / response to interleukin-1 / transforming growth factor beta receptor signaling pathway / secretion / negative regulation of protein phosphorylation / TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) / Asymmetric localization of PCP proteins / positive regulation of protein secretion / positive regulation of glucose import / protein kinase C binding / actin filament organization / positive regulation of protein localization to plasma membrane / Schaffer collateral - CA1 synapse / phospholipid binding / Pre-NOTCH Transcription and Translation / positive regulation of neuron projection development / cellular response to insulin stimulus / microtubule cytoskeleton / KEAP1-NFE2L2 pathway / cell migration / positive regulation of NF-kappaB transcription factor activity / cell cortex / negative regulation of neuron apoptotic process / protein kinase activity / intracellular signal transduction / endosome / apical plasma membrane / cell division / Golgi membrane / protein phosphorylation / protein serine kinase activity / protein serine/threonine kinase activity / centrosome / glutamatergic synapse / negative regulation of apoptotic process / extracellular exosome / nucleoplasm / ATP binding / nucleus / metal ion binding / plasma membrane / cytosol Similarity search - Function Partitioning defective 6 homologue alpha / Partitioning defective protein 6, PB1 domain / Atypical protein kinase C iota type, catalytic domain / Protein kinase C / Protein kinase C, PB1 domain / PB1 domain / PB1 domain / PB1 domain profile. / PB1 domain / Protein kinase, C-terminal ... Partitioning defective 6 homologue alpha / Partitioning defective protein 6, PB1 domain / Atypical protein kinase C iota type, catalytic domain / Protein kinase C / Protein kinase C, PB1 domain / PB1 domain / PB1 domain / PB1 domain profile. / PB1 domain / Protein kinase, C-terminal / Protein kinase C terminal domain / Diacylglycerol/phorbol-ester binding / Phorbol esters/diacylglycerol binding domain (C1 domain) / Zinc finger phorbol-ester/DAG-type signature. / Zinc finger phorbol-ester/DAG-type profile. / Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains) / Protein kinase C-like, phorbol ester/diacylglycerol-binding domain / C1-like domain superfamily / Extension to Ser/Thr-type protein kinases / AGC-kinase, C-terminal / AGC-kinase C-terminal domain profile. / Phosphatidylinositol 3-kinase Catalytic Subunit; Chain A, domain 1 / PDZ domain / PDZ domain profile. / Domain present in PSD-95, Dlg, and ZO-1/2. / PDZ domain / PDZ superfamily / Ubiquitin-like (UB roll) / Serine/threonine-protein kinase, active site / Serine/Threonine protein kinases active-site signature. / Protein kinase domain / Serine/Threonine protein kinases, catalytic domain / Roll / Protein kinase, ATP binding site / Protein kinases ATP-binding region signature. / Protein kinase domain profile. / Protein kinase domain / Protein kinase-like domain superfamily / Alpha Beta Similarity search - Domain/homologyBiological species Homo sapiens (human)Method X-RAY DIFFRACTION / SYNCHROTRON / MAD / Resolution : 1.5 Å DetailsAuthors Hirano, Y. / Yoshinaga, S. / Suzuki, N.N. / Horiuchi, M. / Kohjima, M. / Takeya, R. / Sumimoto, H. / Inagaki, F. CitationJournal : J.Biol.Chem. / Year : 2005Title : Structure of a Cell Polarity Regulator, a Complex between Atypical PKC and Par6 PB1 DomainsAuthors : Hirano, Y. / Yoshinaga, S. / Takeya, R. / Suzuki, N.N. / Horiuchi, M. / Kohjima, M. / Sumimoto, H. / Inagaki, F. History Deposition Jul 9, 2004 Deposition site : PDBJ / Processing site : PDBJRevision 1.0 Dec 7, 2004 Provider : repository / Type : Initial releaseRevision 1.1 Apr 30, 2008 Group : Version format complianceRevision 1.2 Jul 13, 2011 Group : Version format complianceRevision 2.0 Mar 13, 2024 Group : Atomic model / Data collection / Database referencesCategory : atom_site / chem_comp_atom ... atom_site / chem_comp_atom / chem_comp_bond / database_2 / struct_ref_seq_dif Item : _atom_site.occupancy / _database_2.pdbx_DOI ... _atom_site.occupancy / _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _struct_ref_seq_dif.details
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