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Yorodumi- PDB-1w2s: Solution structure of CR2 SCR 1-2 in its complex with C3d by X-ra... -
+Open data
-Basic information
Entry | Database: PDB / ID: 1w2s | ||||||
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Title | Solution structure of CR2 SCR 1-2 in its complex with C3d by X-ray scattering | ||||||
Components |
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Keywords | IMMUNE SYSTEM / X-RAY SCATTERING / ANALYTICAL ULTRACENTRIFUGATION / COMPLEMENT / THROMBOSPONDIN TYPE I REPEATS / CONSTRAINED MODELLING / GLYCOPROTEIN / IMMUNOLOGY | ||||||
Function / homology | Function and homology information complement receptor activity / negative regulation of complement activation, classical pathway / T cell mediated immunity / oviduct epithelium development / C5L2 anaphylatoxin chemotactic receptor binding / regulation of triglyceride biosynthetic process / positive regulation of activation of membrane attack complex / complement binding / vertebrate eye-specific patterning / positive regulation of apoptotic cell clearance ...complement receptor activity / negative regulation of complement activation, classical pathway / T cell mediated immunity / oviduct epithelium development / C5L2 anaphylatoxin chemotactic receptor binding / regulation of triglyceride biosynthetic process / positive regulation of activation of membrane attack complex / complement binding / vertebrate eye-specific patterning / positive regulation of apoptotic cell clearance / complement-mediated synapse pruning / Alternative complement activation / positive regulation of lipid storage / positive regulation of phagocytosis, engulfment / positive regulation of G protein-coupled receptor signaling pathway / complement receptor mediated signaling pathway / Activation of C3 and C5 / positive regulation of type IIa hypersensitivity / positive regulation of glucose transmembrane transport / complement-dependent cytotoxicity / complement activation, alternative pathway / complement activation / endopeptidase inhibitor activity / neuron remodeling / B cell proliferation / amyloid-beta clearance / positive regulation of vascular endothelial growth factor production / immunoglobulin receptor binding / Purinergic signaling in leishmaniasis infection / fatty acid metabolic process / Peptide ligand-binding receptors / B cell differentiation / complement activation, classical pathway / Regulation of Complement cascade / Post-translational protein phosphorylation / response to bacterium / transmembrane signaling receptor activity / positive regulation of receptor-mediated endocytosis / positive regulation of angiogenesis / Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) / Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell / azurophil granule lumen / virus receptor activity / G alpha (i) signalling events / secretory granule lumen / receptor complex / blood microparticle / positive regulation of protein phosphorylation / inflammatory response / immune response / G protein-coupled receptor signaling pathway / endoplasmic reticulum lumen / signaling receptor binding / Neutrophil degranulation / cell surface / signal transduction / protein homodimerization activity / protein-containing complex / DNA binding / extracellular space / extracellular exosome / extracellular region / membrane / plasma membrane Similarity search - Function | ||||||
Biological species | HOMO SAPIENS (human) | ||||||
Method | SOLUTION SCATTERING | ||||||
Model type details | CA ATOMS ONLY, CHAIN A, B | ||||||
Authors | Gilbert, H.E. / Hannan, J.P. / Holers, V.M. / Perkins, S.J. | ||||||
Citation | Journal: J.Mol.Biol. / Year: 2005 Title: Solution Structure of the Complex between Cr2 Scr 1-2 and C3D of Human Complement: An X-Ray Scattering and Sedimentation Modelling Study. Authors: Gilbert, H.E. / Eaton, J.T. / Hannan, J.P. / Holers, V.M. / Perkins, S.J. | ||||||
History |
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-Structure visualization
Structure viewer | Molecule: MolmilJmol/JSmol |
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-Downloads & links
-Download
PDBx/mmCIF format | 1w2s.cif.gz | 77.9 KB | Display | PDBx/mmCIF format |
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PDB format | pdb1w2s.ent.gz | 58.4 KB | Display | PDB format |
PDBx/mmJSON format | 1w2s.json.gz | Tree view | PDBx/mmJSON format | |
Others | Other downloads |
-Validation report
Summary document | 1w2s_validation.pdf.gz | 301.4 KB | Display | wwPDB validaton report |
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Full document | 1w2s_full_validation.pdf.gz | 301.8 KB | Display | |
Data in XML | 1w2s_validation.xml.gz | 1 KB | Display | |
Data in CIF | 1w2s_validation.cif.gz | 17.7 KB | Display | |
Arichive directory | https://data.pdbj.org/pub/pdb/validation_reports/w2/1w2s ftp://data.pdbj.org/pub/pdb/validation_reports/w2/1w2s | HTTPS FTP |
-Related structure data
-Links
-Assembly
Deposited unit |
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1 |
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-Components
#1: Protein | Mass: 34379.281 Da / Num. of mol.: 1 Source method: isolated from a genetically manipulated source Source: (gene. exp.) HOMO SAPIENS (human) / Plasmid: PET11B / Production host: ESCHERICHIA COLI (E. coli) / Strain (production host): BL21 / References: UniProt: P01024 |
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#2: Protein | Mass: 15611.923 Da / Num. of mol.: 1 Source method: isolated from a genetically manipulated source Source: (gene. exp.) HOMO SAPIENS (human) / Production host: PICHIA PASTORIS (fungus) / References: UniProt: P20023 |
-Experimental details
-Experiment
Experiment | Method: SOLUTION SCATTERING |
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-Data collection
Soln scatter |
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-Processing
Software | Name: INSIGHT / Version: II 98 / Classification: refinement | ||||||||||||
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Refinement step | Cycle: LAST
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Soln scatter model | Num. of conformers submitted: 6 / Representative conformer: 1 / Software author list: MSI / Software list: INSIGHT II, SCTPL7, GNOM |