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- PDB-1w2s: Solution structure of CR2 SCR 1-2 in its complex with C3d by X-ra... -
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Open data
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Basic information
Entry | Database: PDB / ID: 1w2s | ||||||
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Title | Solution structure of CR2 SCR 1-2 in its complex with C3d by X-ray scattering | ||||||
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![]() | IMMUNE SYSTEM / X-RAY SCATTERING / ANALYTICAL ULTRACENTRIFUGATION / COMPLEMENT / THROMBOSPONDIN TYPE I REPEATS / CONSTRAINED MODELLING / GLYCOPROTEIN / IMMUNOLOGY | ||||||
Function / homology | ![]() complement receptor activity / oviduct epithelium development / C5L2 anaphylatoxin chemotactic receptor binding / regulation of triglyceride biosynthetic process / positive regulation of activation of membrane attack complex / complement binding / negative regulation of complement activation, classical pathway / vertebrate eye-specific patterning / positive regulation of apoptotic cell clearance / complement-mediated synapse pruning ...complement receptor activity / oviduct epithelium development / C5L2 anaphylatoxin chemotactic receptor binding / regulation of triglyceride biosynthetic process / positive regulation of activation of membrane attack complex / complement binding / negative regulation of complement activation, classical pathway / vertebrate eye-specific patterning / positive regulation of apoptotic cell clearance / complement-mediated synapse pruning / T cell mediated immunity / Alternative complement activation / positive regulation of G protein-coupled receptor signaling pathway / positive regulation of lipid storage / positive regulation of phagocytosis, engulfment / complement receptor mediated signaling pathway / Activation of C3 and C5 / positive regulation of type IIa hypersensitivity / positive regulation of glucose transmembrane transport / complement-dependent cytotoxicity / complement activation, alternative pathway / complement activation / neuron remodeling / endopeptidase inhibitor activity / B cell proliferation / amyloid-beta clearance / positive regulation of vascular endothelial growth factor production / Purinergic signaling in leishmaniasis infection / immunoglobulin receptor binding / Peptide ligand-binding receptors / B cell differentiation / fatty acid metabolic process / complement activation, classical pathway / Regulation of Complement cascade / Post-translational protein phosphorylation / response to bacterium / positive regulation of receptor-mediated endocytosis / transmembrane signaling receptor activity / positive regulation of angiogenesis / Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) / Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell / azurophil granule lumen / virus receptor activity / G alpha (i) signalling events / secretory granule lumen / receptor complex / blood microparticle / inflammatory response / positive regulation of protein phosphorylation / immune response / G protein-coupled receptor signaling pathway / endoplasmic reticulum lumen / signaling receptor binding / Neutrophil degranulation / cell surface / signal transduction / protein homodimerization activity / protein-containing complex / DNA binding / extracellular space / extracellular exosome / extracellular region / membrane / plasma membrane Similarity search - Function | ||||||
Biological species | ![]() | ||||||
Method | ![]() | ||||||
Model type details | CA ATOMS ONLY, CHAIN A, B | ||||||
![]() | Gilbert, H.E. / Hannan, J.P. / Holers, V.M. / Perkins, S.J. | ||||||
![]() | ![]() Title: Solution Structure of the Complex between Cr2 Scr 1-2 and C3D of Human Complement: An X-Ray Scattering and Sedimentation Modelling Study. Authors: Gilbert, H.E. / Eaton, J.T. / Hannan, J.P. / Holers, V.M. / Perkins, S.J. | ||||||
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Structure visualization
Structure viewer | Molecule: ![]() ![]() |
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Downloads & links
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Download
PDBx/mmCIF format | ![]() | 77.9 KB | Display | ![]() |
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PDB format | ![]() | 58.4 KB | Display | ![]() |
PDBx/mmJSON format | ![]() | Tree view | ![]() | |
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-Validation report
Summary document | ![]() | 301.4 KB | Display | ![]() |
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Full document | ![]() | 301.8 KB | Display | |
Data in XML | ![]() | 1 KB | Display | |
Data in CIF | ![]() | 17.7 KB | Display | |
Arichive directory | ![]() ![]() | HTTPS FTP |
-Related structure data
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Links
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Assembly
Deposited unit | ![]()
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1 |
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Components
#1: Protein | Mass: 34379.281 Da / Num. of mol.: 1 Source method: isolated from a genetically manipulated source Source: (gene. exp.) ![]() ![]() ![]() |
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#2: Protein | Mass: 15611.923 Da / Num. of mol.: 1 Source method: isolated from a genetically manipulated source Source: (gene. exp.) ![]() ![]() |
-Experimental details
-Experiment
Experiment | Method: ![]() |
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-Data collection
Soln scatter |
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Processing
Software | Name: INSIGHT / Version: II 98 / Classification: refinement | ||||||||||||
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Refinement step | Cycle: LAST
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Soln scatter model | Num. of conformers submitted: 6 / Representative conformer: 1 / Software author list: MSI / Software list: INSIGHT II, SCTPL7, GNOM |