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- PDB-1utr: UTEROGLOBIN-PCB COMPLEX (REDUCED FORM) -

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Open data


ID or keywords:

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Basic information

Entry
Database: PDB / ID: 1utr
TitleUTEROGLOBIN-PCB COMPLEX (REDUCED FORM)
ComponentsUTEROGLOBIN
KeywordsMAMMALIAN PCB-BINDING PROTEIN / UTEROGLOBIN / CLARA CELL 17 KDA PROTEIN (CC10) / PHOSPHOLIPASE A2 INHIBITOR / CLARA CELL PHOSPHOLIPID-BINDING PROTEIN / PROGESTERONE BINDING
Function / homology
Function and homology information


polychlorinated biphenyl binding / negative regulation of interleukin-4 production / negative regulation of interleukin-5 production / negative regulation of interleukin-13 production / response to silicon dioxide / phospholipase A2 inhibitor activity / response to ozone / response to fibroblast growth factor / negative regulation of type II interferon production / T cell proliferation ...polychlorinated biphenyl binding / negative regulation of interleukin-4 production / negative regulation of interleukin-5 production / negative regulation of interleukin-13 production / response to silicon dioxide / phospholipase A2 inhibitor activity / response to ozone / response to fibroblast growth factor / negative regulation of type II interferon production / T cell proliferation / response to glucocorticoid / negative regulation of T cell proliferation / regulation of mRNA stability / secretory granule / response to organic substance / response to cytokine / nuclear envelope / regulation of inflammatory response / response to lipopolysaccharide / response to xenobiotic stimulus / negative regulation of transcription by RNA polymerase II / signal transduction / extracellular space / cytoplasm
Similarity search - Function
Secretoglobin / Uteroglobin / Secretoglobin family 1C-like / Uteroglobin / Secretoglobin / Uteroglobin family / Secretoglobin (SCGB) family profile. / Uteroglobin / Secretoglobin superfamily / Orthogonal Bundle / Mainly Alpha
Similarity search - Domain/homology
Chem-PCB / Uteroglobin
Similarity search - Component
Biological speciesRattus norvegicus (Norway rat)
MethodSOLUTION NMR
AuthorsHard, T. / Barnes, H.J. / Larsson, C. / Gustafsson, J.-A. / Lund, J.
Citation
Journal: Nat.Struct.Biol. / Year: 1995
Title: Solution structure of a mammalian PCB-binding protein in complex with a PCB.
Authors: Hard, T. / Barnes, H.J. / Larsson, C. / Gustafsson, J.A. / Lund, J.
#1: Journal: Protein Eng. / Year: 1995
Title: Progesterone Binding to Uteroglobin: Two Alternative Conformations of the Ligand
Authors: Dunkel, R. / Vriend, G. / Beato, M. / Suske, G.
#2: Journal: J.Biol.Chem. / Year: 1994
Title: Heterologous Expression of Human Uteroglobin (Slash) Polychlorinated Biphenyl-Binding Protein
Authors: Andersson, O. / Nordlund-Moeller, L. / Barnes, H.J. / Lund, J.
#3: Journal: J.Mol.Biol. / Year: 1992
Title: Cloning, Structure, and Expression of a Rat Binding Protein for Polychlorinated Biphenyls
Authors: Nordlund-Moeller, L. / Andersson, O. / Ahlgren, R. / Schilling, J. / Gillner, M. / Gustafsson, J.-A. / Lund, J.
History
DepositionSep 1, 1995Processing site: BNL
Revision 1.0Dec 7, 1995Provider: repository / Type: Initial release
Revision 1.1Mar 24, 2008Group: Version format compliance
Revision 1.2Jul 13, 2011Group: Version format compliance
Revision 1.3Mar 2, 2022Group: Database references / Derived calculations / Other
Category: database_2 / pdbx_database_status ...database_2 / pdbx_database_status / pdbx_struct_assembly / pdbx_struct_oper_list / struct_site
Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession ..._database_2.pdbx_DOI / _database_2.pdbx_database_accession / _pdbx_database_status.process_site / _struct_site.pdbx_auth_asym_id / _struct_site.pdbx_auth_comp_id / _struct_site.pdbx_auth_seq_id
Revision 1.4May 22, 2024Group: Data collection / Category: chem_comp_atom / chem_comp_bond

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Structure visualization

Structure viewerMolecule:
MolmilJmol/JSmol

Downloads & links

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Assembly

Deposited unit
A: UTEROGLOBIN
B: UTEROGLOBIN
hetero molecules


Theoretical massNumber of molelcules
Total (without water)21,3633
Polymers20,9142
Non-polymers4481
Water0
1


  • Idetical with deposited unit
  • defined by author
TypeNameSymmetry operationNumber
identity operation1_555x,y,z1
NMR ensembles
DataCriteria
Number of conformers (submitted / calculated)1 / -
Representative

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Components

#1: Protein UTEROGLOBIN / / MAMMALIAN PCB-BINDING PROTEIN


Mass: 10457.207 Da / Num. of mol.: 2
Source method: isolated from a genetically manipulated source
Details: TEMPERATURE=30C, PH=7.8, 25 MM PHOSPHATE BUFFER / Source: (gene. exp.) Rattus norvegicus (Norway rat) / Gene: POTENTIAL / Organ: LUNG / Production host: Escherichia coli (E. coli) / References: UniProt: P17559
#2: Chemical ChemComp-PCB / 4,4'-BIS([H]METHYLSULFONYL)-2,2',5,5'-TETRACHLOROBIPHENYL


Mass: 448.169 Da / Num. of mol.: 1 / Source method: obtained synthetically / Formula: C14H10Cl4O4S2

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Experimental details

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Experiment

ExperimentMethod: SOLUTION NMR

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Sample preparation

Crystal grow
*PLUS
Method: other

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Processing

Software
NameVersionClassification
X-PLOR3.1model building
X-PLOR3.1refinement
X-PLOR3.1phasing
NMR softwareName: X-PLOR / Version: 3.1 / Developer: BRUNGER / Classification: refinement
NMR ensembleConformers submitted total number: 1

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