登録情報 | データベース: PDB / ID: 1ug3 |
---|
タイトル | C-terminal portion of human eIF4GI |
---|
要素 | eukaryotic protein synthesis initiation factor 4G |
---|
キーワード | TRANSLATION / EIF4G / HEAT REPEAT |
---|
機能・相同性 | 機能・相同性情報
positive regulation of eukaryotic translation initiation factor 4F complex assembly / positive regulation of mRNA cap binding / positive regulation of translation in response to endoplasmic reticulum stress / cap-dependent translational initiation / macromolecule biosynthetic process / Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S / regulation of cellular response to stress / eukaryotic initiation factor 4E binding / Z-decay: degradation of maternal mRNAs by zygotically expressed factors / eukaryotic translation initiation factor 4F complex ...positive regulation of eukaryotic translation initiation factor 4F complex assembly / positive regulation of mRNA cap binding / positive regulation of translation in response to endoplasmic reticulum stress / cap-dependent translational initiation / macromolecule biosynthetic process / Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S / regulation of cellular response to stress / eukaryotic initiation factor 4E binding / Z-decay: degradation of maternal mRNAs by zygotically expressed factors / eukaryotic translation initiation factor 4F complex / Deadenylation of mRNA / translation factor activity, RNA binding / miRNA-mediated gene silencing by inhibition of translation / M-decay: degradation of maternal mRNAs by maternally stored factors / positive regulation of protein localization to cell periphery / regulation of translational initiation / Translation initiation complex formation / Ribosomal scanning and start codon recognition / negative regulation of peptidyl-threonine phosphorylation / mTORC1-mediated signalling / cellular response to nutrient levels / Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) / regulation of presynapse assembly / L13a-mediated translational silencing of Ceruloplasmin expression / GTP hydrolysis and joining of the 60S ribosomal subunit / behavioral fear response / positive regulation of G1/S transition of mitotic cell cycle / Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) / energy homeostasis / translation initiation factor binding / translational initiation / positive regulation of protein metabolic process / translation initiation factor activity / positive regulation of neuron differentiation / negative regulation of autophagy / AUF1 (hnRNP D0) binds and destabilizes mRNA / lung development / neuron differentiation / ISG15 antiviral mechanism / Regulation of expression of SLITs and ROBOs / cytoplasmic stress granule / positive regulation of peptidyl-serine phosphorylation / positive regulation of cell growth / postsynapse / response to ethanol / molecular adaptor activity / ribosome / translation / mRNA binding / RNA binding / ATP binding / identical protein binding / membrane / nucleus / cytoplasm / cytosol類似検索 - 分子機能 Initiation factor 4G / Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat - #180 / eIF4-gamma/eIF5/eIF2-epsilon / Domain at the C-termini of GCD6, eIF-2B epsilon, eIF-4 gamma and eIF-5 / W2 domain / W2 domain profile. / Initiation factor eIF-4 gamma, MA3 / MA3 domain / MI domain profile. / Domain in DAP-5, eIF4G, MA-3 and other proteins. ...Initiation factor 4G / Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat - #180 / eIF4-gamma/eIF5/eIF2-epsilon / Domain at the C-termini of GCD6, eIF-2B epsilon, eIF-4 gamma and eIF-5 / W2 domain / W2 domain profile. / Initiation factor eIF-4 gamma, MA3 / MA3 domain / MI domain profile. / Domain in DAP-5, eIF4G, MA-3 and other proteins. / MIF4G domain / Middle domain of eukaryotic initiation factor 4G (eIF4G) / MIF4G-like, type 3 / Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat / Alpha Horseshoe / Armadillo-type fold / Mainly Alpha類似検索 - ドメイン・相同性 Eukaryotic translation initiation factor 4 gamma 1類似検索 - 構成要素 |
---|
生物種 | Homo sapiens (ヒト) |
---|
手法 | X線回折 / シンクロトロン / 多波長異常分散 / 解像度: 2.24 Å |
---|
データ登録者 | Bellsolell, L. / Cho-Park, P.F. / Poulin, F. / Sonenberg, N. / Burley, S.K. |
---|
引用 | ジャーナル: Structure / 年: 2006 タイトル: Two structurally atypical HEAT domains in the C-terminal portion of human eIF4G support binding to eIF4A and Mnk1 著者: Bellsolell, L. / Cho-Park, P.F. / Poulin, F. / Sonenberg, N. / Burley, S.K. |
---|
履歴 | 登録 | 2003年6月11日 | 登録サイト: PDBJ / 処理サイト: PDBJ |
---|
改定 1.0 | 2005年3月22日 | Provider: repository / タイプ: Initial release |
---|
改定 1.1 | 2008年4月27日 | Group: Version format compliance |
---|
改定 1.2 | 2011年7月13日 | Group: Version format compliance |
---|
改定 1.3 | 2021年2月3日 | Group: Database references / Structure summary / カテゴリ: audit_author / citation_author Item: _audit_author.identifier_ORCID / _citation_author.identifier_ORCID |
---|
改定 1.4 | 2021年11月10日 | Group: Database references / カテゴリ: database_2 / struct_ref_seq_dif Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _struct_ref_seq_dif.details |
---|
改定 1.5 | 2023年12月27日 | Group: Data collection / カテゴリ: chem_comp_atom / chem_comp_bond |
---|
|
---|