Entry Database : PDB / ID : 1ud0 Structure visualization Downloads & linksTitle CRYSTAL STRUCTURE OF THE C-TERMINAL 10-kDA SUBDOMAIN OF HSC70 Components70 kDa heat-shock-like protein Details Keywords CHAPERONE / HSC70Function / homology Function and homology informationFunction Domain/homology Component
Attenuation phase / PKR-mediated signaling / protein transmembrane import into intracellular organelle / positive regulation of lysosomal membrane permeability / positive regulation of protein refolding / prostaglandin binding / slow axonal transport / clathrin-uncoating ATPase activity / lysosomal matrix / Protein methylation ... Attenuation phase / PKR-mediated signaling / protein transmembrane import into intracellular organelle / positive regulation of lysosomal membrane permeability / positive regulation of protein refolding / prostaglandin binding / slow axonal transport / clathrin-uncoating ATPase activity / lysosomal matrix / Protein methylation / mRNA Splicing - Major Pathway / A1 adenosine receptor binding / late endosomal microautophagy / AUF1 (hnRNP D0) binds and destabilizes mRNA / HSF1-dependent transactivation / response to nickel cation / negative regulation of supramolecular fiber organization / chaperone-mediated autophagy translocation complex disassembly / HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand / response to odorant / Lysosome Vesicle Biogenesis / protein targeting to lysosome involved in chaperone-mediated autophagy / host-mediated activation of viral genome replication / Regulation of HSF1-mediated heat shock response / GABA synthesis, release, reuptake and degradation / Golgi Associated Vesicle Biogenesis / photoreceptor ribbon synapse / clathrin coat disassembly / C3HC4-type RING finger domain binding / protein-containing complex disassembly / host-mediated perturbation of viral process / negative regulation of NLRP3 inflammasome complex assembly / regulation of protein complex stability / maintenance of postsynaptic specialization structure / Clathrin-mediated endocytosis / neuron spine / ATP-dependent protein disaggregase activity / positive regulation of mRNA splicing, via spliceosome / glycinergic synapse / axo-dendritic transport / regulation of postsynapse organization / intermediate filament / protein folding chaperone complex / negative regulation of cardiac muscle cell apoptotic process / Neutrophil degranulation / postsynaptic specialization membrane / cellular response to cadmium ion / response to starvation / phosphatidylserine binding / chaperone-mediated autophagy / non-chaperonin molecular chaperone ATPase / positive regulation of proteolysis / : / asymmetric synapse / Prp19 complex / forebrain development / estrous cycle / ATP metabolic process / skeletal muscle tissue development / : / positive regulation of phagocytosis / heat shock protein binding / photoreceptor inner segment / peptide binding / protein folding chaperone / lysosomal lumen / autophagosome / RNA splicing / response to progesterone / cerebellum development / dendritic shaft / response to activity / spliceosomal complex / kidney development / ATP-dependent protein folding chaperone / G protein-coupled receptor binding / G1/S transition of mitotic cell cycle / ADP binding / regulation of protein stability / positive regulation of T cell mediated cytotoxicity / cellular response to hydrogen peroxide / terminal bouton / mRNA processing / protein import into nucleus / unfolded protein binding / late endosome / melanosome / synaptic vesicle / protein folding / response to estradiol / presynapse / protein-folding chaperone binding / cellular response to heat / protein refolding / response to ethanol / perikaryon / protein-macromolecule adaptor activity / dendritic spine / microtubule / postsynapse Similarity search - Function Substrate Binding Domain Of Dnak; Chain:A; Domain 2 - #10 / Heat shock hsp70 proteins family signature 2. / Heat shock hsp70 proteins family signature 1. / Heat shock hsp70 proteins family signature 3. / Heat shock protein 70, conserved site / Heat shock protein 70kD, peptide-binding domain superfamily / Heat shock protein 70 family / Hsp70 protein / Heat shock protein 70kD, C-terminal domain superfamily / Substrate Binding Domain Of Dnak; Chain:A; Domain 2 ... Substrate Binding Domain Of Dnak; Chain:A; Domain 2 - #10 / Heat shock hsp70 proteins family signature 2. / Heat shock hsp70 proteins family signature 1. / Heat shock hsp70 proteins family signature 3. / Heat shock protein 70, conserved site / Heat shock protein 70kD, peptide-binding domain superfamily / Heat shock protein 70 family / Hsp70 protein / Heat shock protein 70kD, C-terminal domain superfamily / Substrate Binding Domain Of Dnak; Chain:A; Domain 2 / ATPase, nucleotide binding domain / Up-down Bundle / Mainly Alpha Similarity search - Domain/homologyBiological species Rattus norvegicus (Norway rat)Method X-RAY DIFFRACTION / SYNCHROTRON / MAD / Resolution : 3.45 Å DetailsAuthors Chou, C.C. / Forouhar, F. / Yeh, Y.H. / Wang, C. / Hsiao, C.D. CitationJournal : J.BIOL.CHEM. / Year : 2003Title : Crystal structure of the C-terminal 10-kDa subdomain of Hsc70Authors : Chou, C.C. / Forouhar, F. / Yeh, Y.H. / Shr, H.L. / Wang, C. / Hsiao, C.D. History Deposition Apr 24, 2003 Deposition site : PDBJ / Processing site : PDBJRevision 1.0 May 11, 2004 Provider : repository / Type : Initial releaseRevision 1.1 Apr 27, 2008 Group : Version format complianceRevision 1.2 Jul 13, 2011 Group : Version format complianceRevision 1.3 Nov 16, 2011 Group : Atomic modelRevision 1.4 Dec 27, 2023 Group : Data collection / Database references / Derived calculationsCategory : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / database_2 / struct_conn / struct_ref_seq_dif / struct_site Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession ... _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _struct_conn.pdbx_dist_value / _struct_conn.pdbx_leaving_atom_flag / _struct_conn.ptnr1_auth_asym_id / _struct_conn.ptnr1_auth_comp_id / _struct_conn.ptnr1_auth_seq_id / _struct_conn.ptnr1_label_asym_id / _struct_conn.ptnr1_label_atom_id / _struct_conn.ptnr1_label_comp_id / _struct_conn.ptnr1_label_seq_id / _struct_conn.ptnr2_auth_asym_id / _struct_conn.ptnr2_auth_seq_id / _struct_conn.ptnr2_label_asym_id / _struct_ref_seq_dif.details / _struct_site.pdbx_auth_asym_id / _struct_site.pdbx_auth_comp_id / _struct_site.pdbx_auth_seq_id Revision 1.5 Nov 13, 2024 Group : Structure summary / Category : pdbx_entry_details / pdbx_modification_feature
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