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- PDB-1tiv: STRUCTURAL STUDIES OF HIV-1 TAT PROTEIN -

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Entry
Database: PDB / ID: 1tiv
TitleSTRUCTURAL STUDIES OF HIV-1 TAT PROTEIN
ComponentsHIV-1 TRANSACTIVATOR PROTEIN
KeywordsTRANSCRIPTION ACTIVATION
Function / homology
Function and homology information


viral gene expression / trans-activation response element binding / regulatory region RNA binding / positive regulation of viral transcription / protein serine/threonine phosphatase inhibitor activity / modulation by virus of host chromatin organization / symbiont-mediated suppression of host translation initiation / host cell nucleolus / actinin binding / negative regulation of peptidyl-threonine phosphorylation ...viral gene expression / trans-activation response element binding / regulatory region RNA binding / positive regulation of viral transcription / protein serine/threonine phosphatase inhibitor activity / modulation by virus of host chromatin organization / symbiont-mediated suppression of host translation initiation / host cell nucleolus / actinin binding / negative regulation of peptidyl-threonine phosphorylation / RNA-binding transcription regulator activity / cyclin binding / positive regulation of transcription elongation by RNA polymerase II / host cell cytoplasm / symbiont-mediated suppression of host type I interferon-mediated signaling pathway / protein domain specific binding / virus-mediated perturbation of host defense response / DNA-templated transcription / extracellular region / metal ion binding
Similarity search - Function
HIV-1 Transactivator Protein / Tat domain / Tat domain superfamily / Immunodeficiency virus transactivating regulatory protein (Tat) / Transactivating regulatory protein (Tat) / Few Secondary Structures / Irregular
Similarity search - Domain/homology
Biological speciesHuman immunodeficiency virus 1
MethodSOLUTION NMR
AuthorsBayer, P. / Kraft, M. / Frank, R. / Roesch, P.
Citation
Journal: J.Mol.Biol. / Year: 1995
Title: Structural studies of HIV-1 Tat protein.
Authors: Bayer, P. / Kraft, M. / Ejchart, A. / Westendorp, M. / Frank, R. / Rosch, P.
#1: Journal: Science / Year: 1994
Title: Structure of the Equine Infectious Anemia Virus Tat Protein
Authors: Willbold, D. / Rosin-Arbesfeld, R. / Sticht, H. / Frank, R. / Roesch, P.
History
DepositionFeb 14, 1995Processing site: BNL
Revision 1.0Jul 31, 1995Provider: repository / Type: Initial release
Revision 1.1Mar 24, 2008Group: Version format compliance
Revision 1.2Jul 13, 2011Group: Version format compliance
Revision 1.3Mar 2, 2022Group: Database references / Derived calculations / Other
Category: database_2 / pdbx_database_status ...database_2 / pdbx_database_status / pdbx_struct_assembly / pdbx_struct_oper_list / struct_ref_seq_dif
Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession ..._database_2.pdbx_DOI / _database_2.pdbx_database_accession / _pdbx_database_status.process_site / _struct_ref_seq_dif.details
Revision 1.4May 22, 2024Group: Data collection / Category: chem_comp_atom / chem_comp_bond

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Structure visualization

Structure viewerMolecule:
MolmilJmol/JSmol

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Assembly

Deposited unit
A: HIV-1 TRANSACTIVATOR PROTEIN


Theoretical massNumber of molelcules
Total (without water)9,7851
Polymers9,7851
Non-polymers00
Water00
1


  • Idetical with deposited unit
  • defined by author
TypeNameSymmetry operationNumber
identity operation1_555x,y,z1
NMR ensembles
DataCriteria
Number of conformers (submitted / calculated)10 / -
Representative

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Components

#1: Protein HIV-1 TRANSACTIVATOR PROTEIN / TAT PROTEIN


Mass: 9785.232 Da / Num. of mol.: 1 / Mutation: THR 40 LYS
Source method: isolated from a genetically manipulated source
Details: NMR, 10 STRUCTURES / Source: (gene. exp.) Human immunodeficiency virus 1 / Genus: Lentivirus / Gene: POTENTIAL / Production host: Escherichia coli (E. coli) / References: UniProt: P12506

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Experimental details

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Experiment

ExperimentMethod: SOLUTION NMR

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Sample preparation

Crystal grow
*PLUS
Method: other / Details: NMR

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Processing

Software
NameVersionClassification
X-PLOR3.1model building
X-PLOR3.1refinement
X-PLOR3.1phasing
NMR softwareName: X-PLOR / Version: 3.1 / Developer: BRUNGER / Classification: refinement
NMR ensembleConformers submitted total number: 10

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