Entry Database : PDB / ID : 1t2k Structure visualization Downloads & linksTitle Structure Of The DNA Binding Domains Of IRF3, ATF-2 and Jun Bound To DNA Components(31-MER) x 2 Cyclic-AMP-dependent transcription factor ATF-2 Interferon regulatory factor 3 Transcription factor AP-1 DetailsKeywords Transcription/DNA / PROTEIN DNA COMPLEX / transcription / Transcription-DNA COMPLEXFunction / homology Function and homology informationFunction Domain/homology Component
abducens nucleus development / hypoglossal nucleus development / detection of cell density / H4 histone acetyltransferase complex / growth plate cartilage chondrocyte proliferation / facial nucleus development / growth plate cartilage chondrocyte differentiation / positive regulation of cardiac muscle myoblast proliferation / cellular response to anisomycin / positive regulation of transforming growth factor beta2 production ... abducens nucleus development / hypoglossal nucleus development / detection of cell density / H4 histone acetyltransferase complex / growth plate cartilage chondrocyte proliferation / facial nucleus development / growth plate cartilage chondrocyte differentiation / positive regulation of cardiac muscle myoblast proliferation / cellular response to anisomycin / positive regulation of transforming growth factor beta2 production / cAMP response element binding / transcription factor AP-1 complex / leucine zipper domain binding / integrated stress response signaling / cellular lipid metabolic process / positive regulation of DNA-templated transcription initiation / IRF3 mediated activation of type 1 IFN / cAMP response element binding protein binding / release from viral latency / MDA-5 signaling pathway / histone H2B acetyltransferase activity / macrophage apoptotic process / positive regulation of mitochondrial membrane permeability involved in apoptotic process / cellular response to leucine starvation / brainstem development / programmed necrotic cell death / NK T cell differentiation / WNT5:FZD7-mediated leishmania damping / vacuole organization / neurofilament cytoskeleton organization / histone H4 acetyltransferase activity / TRIF-dependent toll-like receptor signaling pathway / apoptotic process involved in development / signal transduction involved in regulation of gene expression / SMAD protein signal transduction / NGF-stimulated transcription / IRF3-mediated induction of type I IFN / LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production / positive regulation of cytokine production involved in inflammatory response / positive regulation of type I interferon-mediated signaling pathway / positive regulation by host of viral transcription / cGAS/STING signaling pathway / intrinsic apoptotic signaling pathway in response to hypoxia / mitotic intra-S DNA damage checkpoint signaling / mRNA transcription / motor neuron apoptotic process / response to osmotic stress / toll-like receptor 4 signaling pathway / TRAF6 mediated IRF7 activation / DNA-binding transcription activator activity / cytoplasmic pattern recognition receptor signaling pathway / immune system process / nuclear chromosome / Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models / type I interferon-mediated signaling pathway / cellular response to exogenous dsRNA / hepatocyte apoptotic process / outflow tract morphogenesis / negative regulation of DNA binding / Activation of the AP-1 family of transcription factors / ubiquitin-like protein ligase binding / p38MAPK cascade / R-SMAD binding / antiviral innate immune response / Response of EIF2AK4 (GCN2) to amino acid deficiency / general transcription initiation factor binding / white fat cell differentiation / negative regulation by host of viral transcription / positive regulation of type I interferon production / positive regulation of interferon-alpha production / cis-regulatory region sequence-specific DNA binding / adipose tissue development / BMP signaling pathway / hematopoietic progenitor cell differentiation / histone acetyltransferase activity / JNK cascade / lipopolysaccharide-mediated signaling pathway / transcription initiation-coupled chromatin remodeling / positive regulation of vascular associated smooth muscle cell proliferation / TICAM1-dependent activation of IRF3/IRF7 / cellular response to cadmium ion / Regulation of innate immune responses to cytosolic DNA / positive regulation of interferon-beta production / response to endoplasmic reticulum stress / negative regulation of angiogenesis / Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) / GTPase activator activity / transforming growth factor beta receptor signaling pathway / liver development / Regulation of PTEN gene transcription / Negative regulators of DDX58/IFIH1 signaling / promoter-specific chromatin binding / TP53 Regulates Transcription of DNA Repair Genes / FCERI mediated MAPK activation / RNA polymerase II transcription regulatory region sequence-specific DNA binding / peptidyl-threonine phosphorylation / Heme signaling / MAPK6/MAPK4 signaling / euchromatin / DDX58/IFIH1-mediated induction of interferon-alpha/beta Similarity search - Function Transcription factor cyclic AMP-dependent, CRE-BP1-type / Transcription factor Jun / Jun-like transcription factor / Jun-like transcription factor / Interferon regulatory factor-3 / Interferon-regulatory factor 3 / Interferon-regulatory factor 3 / Interferon regulatory factor, conserved site / bZIP transcription factor / IRF tryptophan pentad repeat DNA-binding domain signature. ... Transcription factor cyclic AMP-dependent, CRE-BP1-type / Transcription factor Jun / Jun-like transcription factor / Jun-like transcription factor / Interferon regulatory factor-3 / Interferon-regulatory factor 3 / Interferon-regulatory factor 3 / Interferon regulatory factor, conserved site / bZIP transcription factor / IRF tryptophan pentad repeat DNA-binding domain signature. / Interferon regulatory factor transcription factor / interferon regulatory factor / Transcription factor, Skn-1-like, DNA-binding domain superfamily / IRF tryptophan pentad repeat DNA-binding domain profile. / Interferon regulatory factor DNA-binding domain / SMAD-like domain superfamily / Single alpha-helices involved in coiled-coils or other helix-helix interfaces - #170 / Basic-leucine zipper (bZIP) domain signature. / Basic-leucine zipper (bZIP) domain profile. / basic region leucin zipper / Basic-leucine zipper domain superfamily / Basic-leucine zipper domain / SMAD/FHA domain superfamily / Zinc finger C2H2 type domain profile. / Zinc finger C2H2 superfamily / Zinc finger C2H2 type domain signature. / Zinc finger C2H2-type / Single alpha-helices involved in coiled-coils or other helix-helix interfaces / Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain / Arc Repressor Mutant, subunit A / Winged helix DNA-binding domain superfamily / Winged helix-like DNA-binding domain superfamily / Up-down Bundle / Orthogonal Bundle / Mainly Alpha Similarity search - Domain/homology DNA / DNA (> 10) / Transcription factor Jun / Cyclic AMP-dependent transcription factor ATF-2 / Interferon regulatory factor 3 Similarity search - ComponentBiological species Homo sapiens (human)Method X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution : 3 Å DetailsAuthors Panne, D. / Maniatis, T. / Harrison, S.C. CitationJournal : Embo J. / Year : 2004Title : Crystal structure of ATF-2/c-Jun and IRF-3 bound to the interferon-beta enhancer.Authors : Panne, D. / Maniatis, T. / Harrison, S.C. History Deposition Apr 21, 2004 Deposition site : RCSB / Processing site : RCSBRevision 1.0 Nov 16, 2004 Provider : repository / Type : Initial releaseRevision 1.1 Apr 30, 2008 Group : Version format complianceRevision 1.2 Jul 13, 2011 Group : Version format complianceRevision 1.3 Oct 27, 2021 Group : Database references / Category : database_2 / struct_ref_seq_difItem : _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _struct_ref_seq_dif.detailsRevision 1.4 Aug 23, 2023 Group : Data collection / Refinement descriptionCategory : chem_comp_atom / chem_comp_bond / pdbx_initial_refinement_model
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