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- PDB-1suh: AMINO-TERMINAL DOMAIN OF EPITHELIAL CADHERIN IN THE CALCIUM BOUND... -

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Entry
Database: PDB / ID: 1suh
TitleAMINO-TERMINAL DOMAIN OF EPITHELIAL CADHERIN IN THE CALCIUM BOUND STATE, NMR, 20 STRUCTURES
ComponentsEPITHELIAL CADHERIN
KeywordsCELL ADHESION / CADHERIN / CALCIUM BINDING
Function / homology
Function and homology information


uterine epithelium development / Apoptotic cleavage of cell adhesion proteins / Regulation of CDH1 posttranslational processing and trafficking to plasma membrane / desmosome assembly / salivary gland cavitation / regulation of branching involved in salivary gland morphogenesis / Adherens junctions interactions / Degradation of the extracellular matrix / RHO GTPases activate IQGAPs / Integrin cell surface interactions ...uterine epithelium development / Apoptotic cleavage of cell adhesion proteins / Regulation of CDH1 posttranslational processing and trafficking to plasma membrane / desmosome assembly / salivary gland cavitation / regulation of branching involved in salivary gland morphogenesis / Adherens junctions interactions / Degradation of the extracellular matrix / RHO GTPases activate IQGAPs / Integrin cell surface interactions / Regulation of CDH1 Function / Degradation of CDH1 / gamma-catenin binding / desmosome / positive regulation of cell-cell adhesion / lateral loop / regulation of protein localization to cell surface / negative regulation of axon extension / cell-cell adhesion mediator activity / alpha-catenin binding / cellular response to indole-3-methanol / trophectodermal cell differentiation / calcium-dependent cell-cell adhesion / bicellular tight junction assembly / intestinal epithelial cell development / Schmidt-Lanterman incisure / regulation of protein catabolic process at postsynapse, modulating synaptic transmission / flotillin complex / cell-cell adhesion mediated by cadherin / adherens junction organization / epithelial cell morphogenesis / catenin complex / regulation of neuron migration / cell-cell junction assembly / node of Ranvier / negative regulation of protein processing / GTPase activating protein binding / negative regulation of cell-cell adhesion / ankyrin binding / cellular response to lithium ion / apical junction complex / homophilic cell-cell adhesion / decidualization / microvillus / establishment of skin barrier / cochlea development / lateral plasma membrane / negative regulation of protein localization to plasma membrane / positive regulation of protein localization / cytoskeletal protein binding / synapse assembly / embryo implantation / cell adhesion molecule binding / axon terminus / protein tyrosine kinase binding / negative regulation of cell migration / cell periphery / protein localization to plasma membrane / adherens junction / trans-Golgi network / cellular response to amino acid stimulus / negative regulation of canonical Wnt signaling pathway / sensory perception of sound / cell-cell adhesion / positive regulation of protein import into nucleus / beta-catenin binding / cell morphogenesis / cytoplasmic side of plasma membrane / negative regulation of epithelial cell proliferation / apical part of cell / cell-cell junction / cell junction / regulation of protein localization / cell migration / lamellipodium / actin cytoskeleton / regulation of gene expression / actin cytoskeleton organization / protein phosphatase binding / molecular adaptor activity / in utero embryonic development / basolateral plasma membrane / endosome / postsynapse / cadherin binding / protein domain specific binding / axon / calcium ion binding / positive regulation of DNA-templated transcription / perinuclear region of cytoplasm / glutamatergic synapse / cell surface / membrane / identical protein binding / plasma membrane / cytoplasm
Similarity search - Function
Cadherin prodomain like / Cadherin prodomain / Cadherin prodomain like / Cadherin, Y-type LIR-motif / Cadherin, Y-type LIR-motif / Cadherin / Catenin binding domain superfamily / Cadherins / Cadherin conserved site / Cadherin domain signature. ...Cadherin prodomain like / Cadherin prodomain / Cadherin prodomain like / Cadherin, Y-type LIR-motif / Cadherin, Y-type LIR-motif / Cadherin / Catenin binding domain superfamily / Cadherins / Cadherin conserved site / Cadherin domain signature. / Cadherin repeats. / Cadherin domain / Cadherin-like / Cadherins domain profile. / Cadherin-like superfamily / Immunoglobulin-like / Sandwich / Mainly Beta
Similarity search - Domain/homology
Biological speciesMus musculus (house mouse)
MethodSOLUTION NMR
AuthorsOverduin, M. / Tong, K.I. / Kay, C.M. / Ikura, M.
Citation
Journal: J.Biomol.NMR / Year: 1996
Title: 1H, 15N and 13C resonance assignments and monomeric structure of the amino-terminal extracellular domain of epithelial cadherin.
Authors: Overduin, M. / Tong, K.I. / Kay, C.M. / Ikura, M.
#1: Journal: Science / Year: 1995
Title: Solution Structure of the Epithelial Cadherin Domain Responsible for Selective Cell Adhesion
Authors: Overduin, M. / Harvey, T.S. / Bagby, S. / Tong, K.I. / Yau, P. / Takeichi, M. / Ikura, M.
History
DepositionJan 30, 1996Processing site: BNL
Revision 1.0Jul 11, 1996Provider: repository / Type: Initial release
Revision 1.1Mar 24, 2008Group: Version format compliance
Revision 1.2Jul 13, 2011Group: Version format compliance
Revision 1.3Mar 2, 2022Group: Database references / Derived calculations / Other
Category: database_2 / pdbx_database_status ...database_2 / pdbx_database_status / pdbx_struct_assembly / pdbx_struct_oper_list
Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _pdbx_database_status.process_site
Revision 1.4May 22, 2024Group: Data collection / Category: chem_comp_atom / chem_comp_bond

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Structure visualization

Structure viewerMolecule:
MolmilJmol/JSmol

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Assembly

Deposited unit
A: EPITHELIAL CADHERIN


Theoretical massNumber of molelcules
Total (without water)16,1501
Polymers16,1501
Non-polymers00
Water00
1


  • Idetical with deposited unit
  • defined by author
TypeNameSymmetry operationNumber
identity operation1_555x,y,z1
NMR ensembles
DataCriteria
Number of conformers (submitted / calculated)20 / -
Representative

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Components

#1: Protein EPITHELIAL CADHERIN / UVOMORULIN


Mass: 16149.927 Da / Num. of mol.: 1 / Fragment: AMINO-TERMINAL DOMAIN RESIDUES 1 - 104
Source method: isolated from a genetically manipulated source
Source: (gene. exp.) Mus musculus (house mouse) / Tissue: EPITHELIAL, NEURAL / Gene: X06115 (GENBANK) / Plasmid: PAS / Gene (production host): X06115 (GENBANK) / Production host: Escherichia coli (E. coli) / References: UniProt: P09803

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Experimental details

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Experiment

ExperimentMethod: SOLUTION NMR

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Sample preparation

Crystal grow
*PLUS
Method: other / Details: NMR

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Processing

NMR ensembleConformers submitted total number: 20

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