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Open data
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Basic information
Entry | Database: PDB / ID: 1sfw | ||||||
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Title | PORCINE PANCREAS PHOSPHOLIPASE A2, NMR, 18 STRUCTURES | ||||||
![]() | PHOSPHOLIPASE A2 | ||||||
![]() | HYDROLASE / PHOSPHOLIPASE A2 / PHOSPHATIDE-2-ACYL-HYDROLASE | ||||||
Function / homology | ![]() positive regulation of podocyte apoptotic process / regulation of glucose import / phosphatidylglycerol metabolic process / phosphatidylcholine metabolic process / phospholipase A2 activity / leukotriene biosynthetic process / neutrophil mediated immunity / calcium-dependent phospholipase A2 activity / phospholipase A2 / bile acid binding ...positive regulation of podocyte apoptotic process / regulation of glucose import / phosphatidylglycerol metabolic process / phosphatidylcholine metabolic process / phospholipase A2 activity / leukotriene biosynthetic process / neutrophil mediated immunity / calcium-dependent phospholipase A2 activity / phospholipase A2 / bile acid binding / positive regulation of calcium ion transport into cytosol / phospholipid metabolic process / lipid catabolic process / neutrophil chemotaxis / positive regulation of interleukin-8 production / positive regulation of MAP kinase activity / phospholipid binding / fatty acid biosynthetic process / cellular response to insulin stimulus / positive regulation of immune response / positive regulation of fibroblast proliferation / positive regulation of NF-kappaB transcription factor activity / intracellular signal transduction / signaling receptor binding / calcium ion binding / positive regulation of cell population proliferation / cell surface / positive regulation of transcription by RNA polymerase II / extracellular region Similarity search - Function | ||||||
Biological species | ![]() ![]() | ||||||
Method | SOLUTION NMR | ||||||
![]() | Van Den Berg, B. / Tessari, M. / Boelens, R. / Dijkman, R. / Kaptein, R. / De Haas, G.H. / Verheij, H.M. | ||||||
![]() | ![]() Title: Solution structure of porcine pancreatic phospholipase A2 complexed with micelles and a competitive inhibitor. Authors: van den Berg, B. / Tessari, M. / Boelens, R. / Dijkman, R. / Kaptein, R. / de Haas, G.H. / Verheij, H.M. #1: ![]() Title: Solution Structure of Porcine Pancreatic Phospholipase A2 Authors: Van Den Berg, B. / Tessari, M. / De Haas, G.H. / Verheij, H.M. / Boelens, R. / Kaptein, R. #2: ![]() Title: NMR Structures of Phospholipase A2 Reveal Conformational Changes During Interfacial Activation Authors: Van Den Berg, B. / Tessari, M. / Boelens, R. / Dijkman, R. / De Haas, G.H. / Kaptein, R. / Verheij, H.M. | ||||||
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Structure visualization
Structure viewer | Molecule: ![]() ![]() |
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PDBx/mmCIF format | ![]() | 366.8 KB | Display | ![]() |
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PDB format | ![]() | 298.7 KB | Display | ![]() |
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-Validation report
Summary document | ![]() | 358.5 KB | Display | ![]() |
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Full document | ![]() | 547.5 KB | Display | |
Data in XML | ![]() | 65.7 KB | Display | |
Data in CIF | ![]() | 84.7 KB | Display | |
Arichive directory | ![]() ![]() | HTTPS FTP |
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Assembly
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#1: Protein | Mass: 14009.714 Da / Num. of mol.: 1 Source method: isolated from a genetically manipulated source Details: THIS ENTRY PRESENTS THE SOLUTION STRUCTURE OF THE ENZYME IN THE PRESENCE OF LIPID MICELLES AND A COMPETITIVE INHIBITOR Source: (gene. exp.) ![]() ![]() Description: DETAILS CONCERNING THE EXPRESSION OF THE PLA2 CAN BE FOUND IN REFERENCES BELOW Gene: PORCINE PANCREAS PLA2 / Organ: PANCREAS / Plasmid: PAB3 (PGEX T2 DERIVED EXPRESSION PLASMID) / Gene (production host): PORCINE PANCREAS PLA2 / Production host: ![]() ![]() |
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#2: Chemical | ChemComp-CA / |
-Experimental details
-Experiment
Experiment | Method: SOLUTION NMR |
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Sample preparation
Crystal grow | *PLUS Method: other / Details: NMR |
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Processing
NMR software | Name: Discover / Developer: BIOSYM / Classification: refinement |
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NMR ensemble | Conformers submitted total number: 18 |