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- PDB-1oef: PEPTIDE OF HUMAN APOE RESIDUES 263-286, NMR, 5 STRUCTURES AT PH 4... -

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Entry
Database: PDB / ID: 1oef
TitlePEPTIDE OF HUMAN APOE RESIDUES 263-286, NMR, 5 STRUCTURES AT PH 4.8, 37 DEGREES CELSIUS AND PEPTIDE:SDS MOLE RATIO OF 1:90
ComponentsAPOLIPOPROTEIN E
KeywordsAPOLIPOPROTEIN / GLYCOPROTEIN / PLASMA / LIPID TRANSPORT / HDL / VLDL / CHYLOMICRON / SIALIC ACID / HEPARIN-BINDING
Function / homology
Function and homology information


lipid transport involved in lipid storage / intermediate-density lipoprotein particle clearance / positive regulation of lipid transport across blood-brain barrier / regulation of cellular response to very-low-density lipoprotein particle stimulus / metal chelating activity / triglyceride-rich lipoprotein particle clearance / discoidal high-density lipoprotein particle / negative regulation of triglyceride metabolic process / maintenance of location in cell / Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors ...lipid transport involved in lipid storage / intermediate-density lipoprotein particle clearance / positive regulation of lipid transport across blood-brain barrier / regulation of cellular response to very-low-density lipoprotein particle stimulus / metal chelating activity / triglyceride-rich lipoprotein particle clearance / discoidal high-density lipoprotein particle / negative regulation of triglyceride metabolic process / maintenance of location in cell / Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors / chylomicron remnant clearance / negative regulation of cholesterol biosynthetic process / chylomicron remnant / lipoprotein particle / regulation of amyloid-beta clearance / intermediate-density lipoprotein particle / NMDA glutamate receptor clustering / very-low-density lipoprotein particle remodeling / acylglycerol homeostasis / Chylomicron clearance / phosphatidylcholine-sterol O-acyltransferase activator activity / positive regulation of phospholipid efflux / lipid carrier activity / positive regulation of low-density lipoprotein particle receptor catabolic process / Chylomicron remodeling / cellular response to lipoprotein particle stimulus / very-low-density lipoprotein particle clearance / Chylomicron assembly / high-density lipoprotein particle clearance / phospholipid efflux / lipoprotein catabolic process / very-low-density lipoprotein particle receptor binding / chylomicron / regulation of protein metabolic process / high-density lipoprotein particle remodeling / multivesicular body, internal vesicle / positive regulation of amyloid-beta clearance / reverse cholesterol transport / positive regulation of cholesterol metabolic process / regulation of amyloid fibril formation / high-density lipoprotein particle assembly / host-mediated activation of viral process / lipoprotein biosynthetic process / melanosome organization / cholesterol transfer activity / low-density lipoprotein particle / regulation of behavioral fear response / cholesterol catabolic process / protein import / high-density lipoprotein particle / very-low-density lipoprotein particle / low-density lipoprotein particle remodeling / response to caloric restriction / amyloid precursor protein metabolic process / heparan sulfate proteoglycan binding / negative regulation of amyloid fibril formation / synaptic transmission, cholinergic / regulation of Cdc42 protein signal transduction / positive regulation of membrane protein ectodomain proteolysis / regulation of amyloid precursor protein catabolic process / negative regulation of endothelial cell migration / HDL remodeling / artery morphogenesis / regulation of cholesterol metabolic process / negative regulation of protein metabolic process / cholesterol efflux / regulation of axon extension / Scavenging by Class A Receptors / triglyceride homeostasis / triglyceride metabolic process / low-density lipoprotein particle receptor binding / positive regulation of amyloid fibril formation / virion assembly / regulation of innate immune response / negative regulation of platelet-derived growth factor receptor signaling pathway / negative regulation of endothelial cell proliferation / antioxidant activity / positive regulation of lipoprotein transport / response to dietary excess / positive regulation of dendritic spine development / lipoprotein particle binding / negative regulation of amyloid-beta formation / AMPA glutamate receptor clustering / locomotory exploration behavior / negative regulation of long-term synaptic potentiation / negative regulation of blood vessel endothelial cell migration / negative regulation of platelet activation / negative regulation of blood coagulation / positive regulation of dendritic spine maintenance / negative regulation of protein secretion / positive regulation of cholesterol efflux / positive regulation of endocytosis / intracellular transport / fatty acid homeostasis / regulation of neuronal synaptic plasticity / regulation of protein-containing complex assembly / long-chain fatty acid transport / positive regulation of lipid biosynthetic process / Nuclear signaling by ERBB4 / long-term memory
Similarity search - Function
Apolipoprotein A/E / : / Apolipoprotein A1/A4/E domain
Similarity search - Domain/homology
Biological speciesHomo sapiens (human)
MethodSOLUTION NMR
AuthorsWang, G. / Pierens, G.K. / Treleaven, W.D. / Sparrow, J.T. / Cushley, R.J.
CitationJournal: Biochemistry / Year: 1996
Title: Conformations of human apolipoprotein E(263-286) and E(267-289) in aqueous solutions of sodium dodecyl sulfate by CD and 1H NMR.
Authors: Wang, G. / Pierens, G.K. / Treleaven, W.D. / Sparrow, J.T. / Cushley, R.J.
History
DepositionMar 16, 1996Processing site: BNL
Revision 1.0Dec 7, 1996Provider: repository / Type: Initial release
Revision 1.1Mar 24, 2008Group: Version format compliance
Revision 1.2Jul 13, 2011Group: Version format compliance
Revision 1.3Feb 23, 2022Group: Database references / Derived calculations / Other
Category: database_2 / pdbx_database_status ...database_2 / pdbx_database_status / pdbx_struct_assembly / pdbx_struct_oper_list
Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _pdbx_database_status.process_site
Revision 1.4May 22, 2024Group: Data collection / Category: chem_comp_atom / chem_comp_bond

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Structure viewerMolecule:
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Assembly

Deposited unit
A: APOLIPOPROTEIN E


Theoretical massNumber of molelcules
Total (without water)2,8201
Polymers2,8201
Non-polymers00
Water00
1


  • Idetical with deposited unit
  • defined by author
TypeNameSymmetry operationNumber
identity operation1_555x,y,z1
NMR ensembles
DataCriteria
Number of conformers (submitted / calculated)5 / -
Representative

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Components

#1: Protein/peptide APOLIPOPROTEIN E / APOE(263-286) / APOLIPOPROTEIN E(263-286)


Mass: 2820.180 Da / Num. of mol.: 1 / Fragment: RESIDUES 263 - 286
Source method: isolated from a genetically manipulated source
Source: (gene. exp.) Homo sapiens (human) / References: UniProt: P02649

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Experimental details

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Experiment

ExperimentMethod: SOLUTION NMR

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Sample preparation

Sample conditionspH: 4.8 / Temperature: 310 K
Crystal grow
*PLUS
Method: other / Details: NMR

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Processing

NMR softwareName: DGII / Developer: HAVEL / Classification: refinement
NMR ensembleConformers submitted total number: 5

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