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基本情報
登録情報 | データベース: PDB / ID: 1n9u | ||||||
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タイトル | Differences and Similarities in Solution Structures of Angiotensin I & II: Implication for Structure-Function Relationship | ||||||
![]() | Angiotensin I | ||||||
![]() | SIGNALING PROTEIN / Angiotensin / Renin-Angiotensin System / Solid Phase Peptide Synthesis / NMR Solution Structure / Peptides | ||||||
機能・相同性 | ![]() regulation of blood volume by renin-angiotensin / response to muscle activity involved in regulation of muscle adaptation / type 2 angiotensin receptor binding / regulation of renal sodium excretion / maintenance of blood vessel diameter homeostasis by renin-angiotensin / negative regulation of neurotrophin TRK receptor signaling pathway / regulation of extracellular matrix assembly / regulation of renal output by angiotensin / : / G protein-coupled receptor signaling pathway coupled to cGMP nucleotide second messenger ...regulation of blood volume by renin-angiotensin / response to muscle activity involved in regulation of muscle adaptation / type 2 angiotensin receptor binding / regulation of renal sodium excretion / maintenance of blood vessel diameter homeostasis by renin-angiotensin / negative regulation of neurotrophin TRK receptor signaling pathway / regulation of extracellular matrix assembly / regulation of renal output by angiotensin / : / G protein-coupled receptor signaling pathway coupled to cGMP nucleotide second messenger / renal system process / renin-angiotensin regulation of aldosterone production / positive regulation of branching involved in ureteric bud morphogenesis / positive regulation of extracellular matrix assembly / positive regulation of macrophage derived foam cell differentiation / vasoconstriction / positive regulation of CoA-transferase activity / type 1 angiotensin receptor binding / low-density lipoprotein particle remodeling / positive regulation of extrinsic apoptotic signaling pathway / response to angiotensin / positive regulation of epidermal growth factor receptor signaling pathway / positive regulation of cardiac muscle hypertrophy / positive regulation of gap junction assembly / positive regulation of protein tyrosine kinase activity / regulation of vasoconstriction / regulation of cardiac conduction / blood vessel remodeling / Metabolism of Angiotensinogen to Angiotensins / positive regulation of epithelial to mesenchymal transition / nitric oxide-cGMP-mediated signaling / positive regulation of protein metabolic process / positive regulation of endothelial cell migration / Peptide ligand-binding receptors / negative regulation of MAP kinase activity / kidney development / positive regulation of cytokine production / angiotensin-activated signaling pathway / regulation of cell growth / growth factor activity / serine-type endopeptidase inhibitor activity / hormone activity / PPARA activates gene expression / regulation of blood pressure / positive regulation of miRNA transcription / positive regulation of inflammatory response / positive regulation of reactive oxygen species metabolic process / positive regulation of fibroblast proliferation / cell-cell signaling / positive regulation of NF-kappaB transcription factor activity / phospholipase C-activating G protein-coupled receptor signaling pathway / regulation of cell population proliferation / G alpha (i) signalling events / G alpha (q) signalling events / regulation of apoptotic process / collagen-containing extracellular matrix / positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction / blood microparticle / G protein-coupled receptor signaling pathway / positive regulation of DNA-templated transcription / extracellular space / extracellular exosome / extracellular region / cytosol 類似検索 - 分子機能 | ||||||
手法 | 溶液NMR / simulated annealing, torsion angle dynamics | ||||||
![]() | Spyroulias, G.A. / Nikolakopoulou, P. / Tzakos, A. / Gerothanassis, I.P. / Magafa, V. / Manessi-Zoupa, E. / Cordopatis, P. | ||||||
![]() | ![]() タイトル: Comparison of the solution structures of angiotensin I & II. Implication for structure-function relationship. 著者: Spyroulias, G.A. / Nikolakopoulou, P. / Tzakos, A. / Gerothanassis, I.P. / Magafa, V. / Manessi-Zoupa, E. / Cordopatis, P. #1: ![]() タイトル: Role of the NH2-terminal domain of angiotensin II (ANG II) and [Sar1]angiotensin II on conformation and activity. NMR evidence for aromatic ring clustering and peptide backbone folding ...タイトル: Role of the NH2-terminal domain of angiotensin II (ANG II) and [Sar1]angiotensin II on conformation and activity. NMR evidence for aromatic ring clustering and peptide backbone folding compared with [des-1,2,3]angiotensin II 著者: Matsoukas, J.M. / Hondrelis, J. / Keramida, M. / Mavromoustakos, T. / Makriyannis, A. / Yamdagni, R. / Wu, Q. / Moore, G.J. | ||||||
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構造の表示
構造ビューア | 分子: ![]() ![]() |
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PDBx/mmCIF形式 | ![]() | 73.5 KB | 表示 | ![]() |
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-検証レポート
文書・要旨 | ![]() | 340.8 KB | 表示 | ![]() |
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文書・詳細版 | ![]() | 403.5 KB | 表示 | |
XML形式データ | ![]() | 4.2 KB | 表示 | |
CIF形式データ | ![]() | 6.4 KB | 表示 | |
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-関連構造データ
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リンク
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集合体
登録構造単位 | ![]()
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NMR アンサンブル |
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要素
#1: タンパク質・ペプチド | 分子量: 1299.499 Da / 分子数: 1 / 由来タイプ: 合成 詳細: THE PEPTIDE WAS made through Solid phase synthesis using Fmoc chemistry. THE SEQUENCE OF THE PEPTIDE IS NATURALLY FOUND IN homo sapiens. 参照: UniProt: P01019 |
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-実験情報
-実験
実験 | 手法: 溶液NMR | ||||||||||||||||
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NMR実験 |
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NMR実験の詳細 | Text: This structure was determined using standard 2D homonuclear techniques. Models 1-20 are the family ensemble, while model 21 is the minimized average structure derived from that ensemble. |
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試料調製
詳細 | 内容: 2.5 mM; DMSO-d6 / 溶媒系: DMSO-d6 |
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試料状態 | 圧: ambient / 温度: 298 K |
結晶化 | *PLUS 手法: other / 詳細: NMR |
-NMR測定
NMRスペクトロメーター | タイプ: Bruker DPX / 製造業者: Bruker / モデル: DPX / 磁場強度: 400 MHz |
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解析
NMR software |
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精密化 | 手法: simulated annealing, torsion angle dynamics / ソフトェア番号: 1 詳細: This structure is based on a 225 NOE-derived distance constraints, 7 dihedral angle restraints, 1 distance restraint from hydrogen bond | ||||||||||||||||||||||||
NMRアンサンブル | コンフォーマー選択の基準: target function for models 1-20, mean energy minimized for model 21 計算したコンフォーマーの数: 300 / 登録したコンフォーマーの数: 21 |