ANTIMICROBIAL PROTEIN / strand-loop-strand / beta-sheet / hairpin loop
Function / homology
Function and homology information
negative regulation of intestinal absorption / iron ion transmembrane transport / macrophage activation / positive regulation of macrophage activation / response to iron ion / negative regulation of bone resorption / negative regulation of iron ion transmembrane transport / myeloid cell homeostasis / cell surface receptor signaling pathway via JAK-STAT / defense response to fungus ...negative regulation of intestinal absorption / iron ion transmembrane transport / macrophage activation / positive regulation of macrophage activation / response to iron ion / negative regulation of bone resorption / negative regulation of iron ion transmembrane transport / myeloid cell homeostasis / cell surface receptor signaling pathway via JAK-STAT / defense response to fungus / establishment of localization in cell / protein catabolic process / hormone activity / multicellular organismal-level iron ion homeostasis / negative regulation of inflammatory response / positive regulation of protein catabolic process / intracellular iron ion homeostasis / killing of cells of another organism / transcription by RNA polymerase II / defense response to bacterium / inflammatory response / immune response / copper ion binding / negative regulation of transcription by RNA polymerase II / positive regulation of transcription by RNA polymerase II / extracellular space / extracellular region / nucleus Similarity search - Function
Mass: 2203.828 Da / Num. of mol.: 1 / Fragment: Hepcidin-20 (residues 65-84) / Source method: obtained synthetically Details: The sequence of the protein is naturally found in Homo sapiens. The protein was chemically synthesized. References: UniProt: P81172
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Experimental details
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Experiment
Experiment
Method: SOLUTION NMR
NMR experiment
Conditions-ID
Experiment-ID
Solution-ID
Type
1
1
1
2D NOESY
1
2
1
2D TOCSY
1
3
1
13C-HSQC
1
4
1
Diffusion
NMR details
Text: This structure was determined using standard 2D homonuclear techniques.
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