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- PDB-1lqh: INSECTICIDAL ALPHA SCORPION TOXIN ISOLATED FROM THE VENOM OF SCOR... -

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Basic information

Entry
Database: PDB / ID: 1lqh
TitleINSECTICIDAL ALPHA SCORPION TOXIN ISOLATED FROM THE VENOM OF SCORPION LEIURUS QUINQUESTRIATUS HEBRAEUS, NMR, MINIMIZED AVERAGE STRUCTURE
ComponentsINSECT TOXIN ALPHA
KeywordsNEUROTOXIN / SODIUM CHANNEL INHIBITOR
Function / homology
Function and homology information


sodium channel inhibitor activity / defense response / toxin activity / extracellular region
Similarity search - Function
Scorpion long chain toxin / LCN-type cysteine-stabilized alpha/beta (CS-alpha/beta) domain / LCN-type cysteine-stabilized alpha/beta (CS-alpha/beta) domain profile. / Scorpion long chain toxin/defensin / Scorpion toxin-like domain / Knottins / Knottin, scorpion toxin-like / Knottin, scorpion toxin-like / Knottin, scorpion toxin-like superfamily / Defensin A-like ...Scorpion long chain toxin / LCN-type cysteine-stabilized alpha/beta (CS-alpha/beta) domain / LCN-type cysteine-stabilized alpha/beta (CS-alpha/beta) domain profile. / Scorpion long chain toxin/defensin / Scorpion toxin-like domain / Knottins / Knottin, scorpion toxin-like / Knottin, scorpion toxin-like / Knottin, scorpion toxin-like superfamily / Defensin A-like / 2-Layer Sandwich / Alpha Beta
Similarity search - Domain/homology
Alpha-insect toxin LqhaIT
Similarity search - Component
Biological speciesLeiurus quinquestriatus hebraeus (scorpion)
MethodSOLUTION NMR
AuthorsTugarinov, V. / Kustanovich, I. / Zilberberg, N. / Gurevitz, M. / Anglister, J.
Citation
Journal: Biochemistry / Year: 1997
Title: Solution structures of a highly insecticidal recombinant scorpion alpha-toxin and a mutant with increased activity.
Authors: Tugarinov, V. / Kustanovich, I. / Zilberberg, N. / Gurevitz, M. / Anglister, J.
#1: Journal: Biochemistry / Year: 1996
Title: Functional Expression and Genetic Alteration of an Alpha Scorpion Neurotoxin
Authors: Zilberberg, N. / Gordon, D. / Pelhate, M. / Adams, M.E. / Norris, T.M. / Zlotkin, E. / Gurevitz, M.
History
DepositionJun 17, 1996Processing site: BNL
Revision 1.0Mar 12, 1997Provider: repository / Type: Initial release
Revision 1.1Mar 24, 2008Group: Version format compliance
Revision 1.2Jul 13, 2011Group: Version format compliance
Revision 1.3Feb 23, 2022Group: Database references / Derived calculations / Other
Category: database_2 / pdbx_database_status ...database_2 / pdbx_database_status / pdbx_struct_assembly / pdbx_struct_oper_list
Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _pdbx_database_status.process_site
Revision 1.4Oct 23, 2024Group: Data collection / Structure summary
Category: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / pdbx_entry_details / pdbx_modification_feature

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Structure visualization

Structure viewerMolecule:
MolmilJmol/JSmol

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Assembly

Deposited unit
A: INSECT TOXIN ALPHA


Theoretical massNumber of molelcules
Total (without water)7,3961
Polymers7,3961
Non-polymers00
Water00
1


  • Idetical with deposited unit
  • defined by author
TypeNameSymmetry operationNumber
identity operation1_555x,y,z1
NMR ensembles
DataCriteria
Number of conformers (submitted / calculated)1 / -
Representative

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Components

#1: Protein INSECT TOXIN ALPHA / NEUROTOXIN / INSECTOTOXIN / SCORPION TOXIN / LQHAIT


Mass: 7396.455 Da / Num. of mol.: 1
Source method: isolated from a genetically manipulated source
Source: (gene. exp.) Leiurus quinquestriatus hebraeus (scorpion)
Species: Leiurus quinquestriatus / Strain: hebraeus / Plasmid: T7 / Production host: Escherichia coli (E. coli) / References: UniProt: P17728
Has protein modificationY

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Experimental details

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Experiment

ExperimentMethod: SOLUTION NMR

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Sample preparation

Crystal grow
*PLUS
Method: other / Details: NMR

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Processing

Software
NameClassification
X-PLORmodel building
X-PLORrefinement
X-PLORphasing
NMR softwareName: X-PLOR / Developer: BRUNGER / Classification: refinement
NMR ensembleConformers submitted total number: 1

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