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- PDB-1ktx: KALIOTOXIN (1-37) SHOWS STRUCTURAL DIFFERENCES WITH RELATED POTAS... -

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Basic information

Entry
Database: PDB / ID: 1ktx
TitleKALIOTOXIN (1-37) SHOWS STRUCTURAL DIFFERENCES WITH RELATED POTASSIUM CHANNEL BLOCKERS
ComponentsKALIOTOXIN
KeywordsNEUROTOXIN(POTASSIUM CHANNEL INHIBITOR)
Function / homologyScorpion short toxins signature. / Scorpion short chain toxin, potassium channel inhibitor / Scorpion short toxin, BmKK2 / Knottin, scorpion toxin-like superfamily / ion channel inhibitor activity / potassium channel regulator activity / toxin activity / extracellular region / Potassium channel toxin alpha-KTx 3.1
Function and homology information
Biological speciesAndroctonus mauretanicus mauretanicus (scorpion)
MethodSOLUTION NMR
AuthorsFernandez, I. / Romi, R. / Szendefi, S. / Martin-Eauclaire, M.-F. / Rochat, H. / Van Rietschtoten, J. / Pons, M. / Giralt, E.
Citation
Journal: Biochemistry / Year: 1994
Title: Kaliotoxin (1-37) shows structural differences with related potassium channel blockers.
Authors: Fernandez, I. / Romi, R. / Szendeffy, S. / Martin-Eauclaire, M.F. / Rochat, H. / Van Rietschoten, J. / Pons, M. / Giralt, E.
#1: Journal: J.Biol.Chem. / Year: 1992
Title: Kaliotoxin, a Novel Peptidyl Inhibitor of Neuronal Bk-Type Ca(2+)-Activated K+ Channels Characterized from Androctonus Mauretanicus Mauretanicus Venom
Authors: Crest, M. / Jacquet, G. / Gola, M. / Zerrouk, H. / Benslimane, A. / Rochat, H. / Mansuelle, P. / Martin-Eauclaire, M.-F.
History
DepositionJun 2, 1994Processing site: BNL
Revision 1.0Jan 26, 1995Provider: repository / Type: Initial release
Revision 1.1Mar 24, 2008Group: Version format compliance
Revision 1.2Jul 13, 2011Group: Version format compliance
Revision 1.3Nov 29, 2017Group: Derived calculations / Other
Category: pdbx_database_status / pdbx_struct_assembly ...pdbx_database_status / pdbx_struct_assembly / pdbx_struct_oper_list / struct_conf / struct_conf_type
Item: _pdbx_database_status.process_site
Revision 1.4Nov 13, 2024Group: Data collection / Database references ...Data collection / Database references / Derived calculations / Structure summary
Category: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / database_2 / pdbx_entry_details / pdbx_modification_feature / pdbx_nmr_software / struct_conn / struct_site
Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession ..._database_2.pdbx_DOI / _database_2.pdbx_database_accession / _pdbx_nmr_software.name / _struct_conn.pdbx_leaving_atom_flag / _struct_site.pdbx_auth_asym_id / _struct_site.pdbx_auth_comp_id / _struct_site.pdbx_auth_seq_id

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Structure visualization

Structure viewerMolecule:
MolmilJmol/JSmol

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Assembly

Deposited unit
A: KALIOTOXIN


Theoretical massNumber of molelcules
Total (without water)4,0341
Polymers4,0341
Non-polymers00
Water00
1


  • Idetical with deposited unit
  • defined by author
TypeNameSymmetry operationNumber
identity operation1_5551
Atom site foot note1: RESIDUE LYS 7 ORDER PARAMETER: PSI=0.82 PHI=0.69.
2: RESIDUE LYS 27 IS OUTSIDE ALLOWED REGION IN RAMACHANDRAN MAP IN SOME STRUCTURES. RESIDUE LYS 27 ORDER PARAMETER: PSI=0.78 PHI=0.82.
3: RESIDUE MET 29 IS OUTSIDE ALLOWED REGION IN RAMACHANDRAN MAP.
4: RESIDUE ASN 30 IS OUTSIDE ALLOWED REGION IN RAMACHANDRAN MAP IN SOME STRUCTURES. RESIDUE ASN 30 ORDER PARAMETER: PSI=0.38 PHI=0.84.
NMR ensembles
DataCriteria
Number of conformers (submitted / calculated)11 / -
Representative

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Components

#1: Protein/peptide KALIOTOXIN


Mass: 4033.880 Da / Num. of mol.: 1
Source method: isolated from a genetically manipulated source
Source: (gene. exp.) Androctonus mauretanicus mauretanicus (scorpion)
Species: Androctonus mauretanicus / Strain: mauretanicus / References: UniProt: P24662
Has protein modificationY

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Experimental details

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Experiment

ExperimentMethod: SOLUTION NMR

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Sample preparation

Crystal grow
*PLUS
Method: other / Details: NMR

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Processing

NMR softwareName: Discover / Classification: refinement
NMR ensembleConformers submitted total number: 11

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