Entry Database : PDB / ID : 1kbf Structure visualization Downloads & linksTitle Solution Structure of the Cysteine-Rich C1 Domain of Kinase Suppressor of Ras ComponentsKinase suppressor of Ras 1 Details Keywords SIGNALING PROTEIN / Cysteine-rich domain / Zinc-binding proteinFunction / homology Function and homology informationFunction Domain/homology Component
Negative regulation of MAPK pathway / RAF activation / MAP2K and MAPK activation / regulation of MAP kinase activity / MAP-kinase scaffold activity / mitogen-activated protein kinase kinase binding / 14-3-3 protein binding / cAMP-mediated signaling / Hsp90 protein binding / ruffle membrane ... Negative regulation of MAPK pathway / RAF activation / MAP2K and MAPK activation / regulation of MAP kinase activity / MAP-kinase scaffold activity / mitogen-activated protein kinase kinase binding / 14-3-3 protein binding / cAMP-mediated signaling / Hsp90 protein binding / ruffle membrane / regulation of cell population proliferation / protein-folding chaperone binding / Ras protein signal transduction / positive regulation of MAPK cascade / non-specific serine/threonine protein kinase / protein kinase activity / phosphorylation / protein serine kinase activity / protein serine/threonine kinase activity / endoplasmic reticulum membrane / protein kinase binding / endoplasmic reticulum / protein-containing complex / ATP binding / membrane / metal ion binding / cytoplasm / cytosol Similarity search - Function Kinase suppressor RAS 1, N-terminal helical hairpin / Kinase suppressor RAS 1, N-terminal helical hairpin superfamily / Kinase suppressor RAS 1 N-terminal helical hairpin / Wheat Germ Agglutinin (Isolectin 2); domain 1 - #20 / Wheat Germ Agglutinin (Isolectin 2); domain 1 / Zinc finger phorbol-ester/DAG-type signature. / Zinc finger phorbol-ester/DAG-type profile. / Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains) / Protein kinase C-like, phorbol ester/diacylglycerol-binding domain / C1-like domain superfamily ... Kinase suppressor RAS 1, N-terminal helical hairpin / Kinase suppressor RAS 1, N-terminal helical hairpin superfamily / Kinase suppressor RAS 1 N-terminal helical hairpin / Wheat Germ Agglutinin (Isolectin 2); domain 1 - #20 / Wheat Germ Agglutinin (Isolectin 2); domain 1 / Zinc finger phorbol-ester/DAG-type signature. / Zinc finger phorbol-ester/DAG-type profile. / Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains) / Protein kinase C-like, phorbol ester/diacylglycerol-binding domain / C1-like domain superfamily / Sterile alpha motif/pointed domain superfamily / Protein tyrosine and serine/threonine kinase / Serine-threonine/tyrosine-protein kinase, catalytic domain / Serine/threonine-protein kinase, active site / Serine/Threonine protein kinases active-site signature. / Serine/Threonine protein kinases, catalytic domain / Protein kinase domain profile. / Protein kinase domain / Protein kinase-like domain superfamily / 2-Layer Sandwich / Alpha Beta Similarity search - Domain/homologyBiological species Mus musculus (house mouse)Method SOLUTION NMR / molecular dynamics DetailsAuthors Zhou, M. / Horita, D.A. / Waugh, D.S. / Byrd, R.A. / Morrison, D.K. CitationJournal : J.Mol.Biol. / Year : 2002Title : Solution structure and functional analysis of the cysteine-rich C1 domain of kinase suppressor of Ras (KSR).Authors : Zhou, M. / Horita, D.A. / Waugh, D.S. / Byrd, R.A. / Morrison, D.K. History Deposition Nov 6, 2001 Deposition site : RCSB / Processing site : RCSBRevision 1.0 Jan 23, 2002 Provider : repository / Type : Initial releaseRevision 1.1 Apr 27, 2008 Group : Version format complianceRevision 1.2 Jul 13, 2011 Group : Version format complianceRevision 1.3 Dec 25, 2019 Group : Database references / Derived calculations / OtherCategory : database_2 / pdbx_database_related ... database_2 / pdbx_database_related / pdbx_database_status / pdbx_struct_assembly / pdbx_struct_oper_list / struct_ref_seq_dif Item : _pdbx_database_status.status_code_cs / _struct_ref_seq_dif.detailsRevision 2.0 Feb 26, 2020 Group : Atomic model / Author supporting evidence ... Atomic model / Author supporting evidence / Data collection / Database references / Derived calculations / Experimental preparation / Other / Refinement description / Source and taxonomy / Structure summary Category : atom_site / diffrn ... atom_site / diffrn / diffrn_radiation / diffrn_radiation_wavelength / entity / entity_name_com / entity_src_gen / pdbx_database_status / pdbx_entity_instance_feature / pdbx_entry_details / pdbx_nmr_exptl / pdbx_nmr_exptl_sample / pdbx_nmr_exptl_sample_conditions / pdbx_nmr_refine / pdbx_nmr_sample_details / pdbx_struct_conn_angle / pdbx_struct_sheet_hbond / pdbx_validate_torsion / pdbx_version / struct / struct_conn / struct_keywords / struct_ref_seq_dif / struct_sheet / struct_sheet_order / struct_sheet_range / struct_site Item : _atom_site.Cartn_x / _atom_site.Cartn_y ... _atom_site.Cartn_x / _atom_site.Cartn_y / _atom_site.Cartn_z / _entity.pdbx_description / _entity.pdbx_ec / _entity.pdbx_fragment / _entity_src_gen.gene_src_common_name / _entity_src_gen.pdbx_beg_seq_num / _entity_src_gen.pdbx_end_seq_num / _entity_src_gen.pdbx_gene_src_gene / _entity_src_gen.pdbx_seq_type / _pdbx_database_status.SG_entry / _pdbx_database_status.status_code_mr / _pdbx_nmr_exptl_sample_conditions.ionic_strength / _pdbx_nmr_exptl_sample_conditions.ionic_strength_units / _pdbx_nmr_exptl_sample_conditions.label / _pdbx_nmr_exptl_sample_conditions.pH_units / _pdbx_nmr_sample_details.contents / _pdbx_nmr_sample_details.label / _pdbx_nmr_sample_details.type / _pdbx_struct_conn_angle.ptnr1_auth_comp_id / _pdbx_struct_conn_angle.ptnr1_auth_seq_id / _pdbx_struct_conn_angle.ptnr1_label_atom_id / _pdbx_struct_conn_angle.ptnr1_label_comp_id / _pdbx_struct_conn_angle.ptnr1_label_seq_id / _pdbx_struct_conn_angle.ptnr3_auth_comp_id / _pdbx_struct_conn_angle.ptnr3_auth_seq_id / _pdbx_struct_conn_angle.ptnr3_label_atom_id / _pdbx_struct_conn_angle.ptnr3_label_comp_id / _pdbx_struct_conn_angle.ptnr3_label_seq_id / _pdbx_struct_conn_angle.value / _pdbx_struct_sheet_hbond.sheet_id / _struct.pdbx_CASP_flag / _struct_conn.pdbx_dist_value / _struct_conn.ptnr1_auth_comp_id / _struct_conn.ptnr1_auth_seq_id / _struct_conn.ptnr1_label_asym_id / _struct_conn.ptnr1_label_atom_id / _struct_conn.ptnr1_label_comp_id / _struct_conn.ptnr1_label_seq_id / _struct_conn.ptnr2_auth_comp_id / _struct_conn.ptnr2_auth_seq_id / _struct_conn.ptnr2_label_asym_id / _struct_conn.ptnr2_label_atom_id / _struct_conn.ptnr2_label_comp_id / _struct_conn.ptnr2_label_seq_id / _struct_keywords.text / _struct_ref_seq_dif.details / _struct_sheet.id / _struct_sheet_order.sheet_id / _struct_sheet_range.sheet_id / _struct_site.details / _struct_site.pdbx_auth_asym_id / _struct_site.pdbx_auth_comp_id / _struct_site.pdbx_auth_seq_id Description : Model orientation/position / Provider : author / Type : Coordinate replacementRevision 2.1 Apr 17, 2024 Group : Data collection / Database references ... Data collection / Database references / Derived calculations / Other Category : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / database_2 / pdbx_database_status / struct_conn Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession ... _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _pdbx_database_status.status_code_mr / _struct_conn.pdbx_dist_value / _struct_conn.ptnr1_auth_comp_id / _struct_conn.ptnr1_auth_seq_id / _struct_conn.ptnr1_label_asym_id / _struct_conn.ptnr1_label_atom_id / _struct_conn.ptnr1_label_comp_id / _struct_conn.ptnr1_label_seq_id / _struct_conn.ptnr2_auth_comp_id / _struct_conn.ptnr2_auth_seq_id / _struct_conn.ptnr2_label_asym_id / _struct_conn.ptnr2_label_atom_id / _struct_conn.ptnr2_label_comp_id / _struct_conn.ptnr2_label_seq_id
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