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- PDB-1jvr: STRUCTURE OF THE HTLV-II MATRIX PROTEIN, NMR, 20 STRUCTURES -

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Basic information

Entry
Database: PDB / ID: 1jvr
TitleSTRUCTURE OF THE HTLV-II MATRIX PROTEIN, NMR, 20 STRUCTURES
ComponentsHUMAN T-CELL LEUKEMIA VIRUS TYPE II MATRIX PROTEIN
KeywordsMATRIX PROTEIN / HUMAN T-CELL LEUKEMIA VIRUS TYPE II MATRIX PROTEIN / HTLV-II MATRIX PROTEIN / HTLV-II MA / RETROVIRAL MATRIX PROTEIN / P17
Function / homology
Function and homology information


Hydrolases; Acting on peptide bonds (peptidases); Aspartic endopeptidases / ribonuclease H / viral process / DNA integration / RNA-directed DNA polymerase / viral genome integration into host DNA / establishment of integrated proviral latency / RNA-directed DNA polymerase activity / Transferases; Transferring phosphorus-containing groups; Nucleotidyltransferases / RNA-DNA hybrid ribonuclease activity ...Hydrolases; Acting on peptide bonds (peptidases); Aspartic endopeptidases / ribonuclease H / viral process / DNA integration / RNA-directed DNA polymerase / viral genome integration into host DNA / establishment of integrated proviral latency / RNA-directed DNA polymerase activity / Transferases; Transferring phosphorus-containing groups; Nucleotidyltransferases / RNA-DNA hybrid ribonuclease activity / viral nucleocapsid / DNA recombination / Hydrolases; Acting on ester bonds / nucleic acid binding / DNA-directed DNA polymerase / aspartic-type endopeptidase activity / DNA-directed DNA polymerase activity / symbiont entry into host cell / symbiont-mediated suppression of host gene expression / structural molecule activity / proteolysis / DNA binding / zinc ion binding
Similarity search - Function
Human T-cell Leukemia Virus Type II Matrix Protein / Delta-retroviral matrix / : / Delta-retroviral matrix protein / Major core protein p19 / Retroviral nucleocapsid Gag protein p24, N-terminal / gag protein p24 N-terminal domain / Integrase Zinc binding domain / Integrase DNA binding domain / Integrase, C-terminal domain superfamily, retroviral ...Human T-cell Leukemia Virus Type II Matrix Protein / Delta-retroviral matrix / : / Delta-retroviral matrix protein / Major core protein p19 / Retroviral nucleocapsid Gag protein p24, N-terminal / gag protein p24 N-terminal domain / Integrase Zinc binding domain / Integrase DNA binding domain / Integrase, C-terminal domain superfamily, retroviral / Integrase, N-terminal zinc-binding domain / Integrase, C-terminal, retroviral / Integrase DNA binding domain profile. / RNase H / Integrase core domain / Integrase, catalytic core / Integrase catalytic domain profile. / Retroviral nucleocapsid Gag protein p24, C-terminal domain / Gag protein p24 C-terminal domain / Ribonuclease H domain / RNase H type-1 domain profile. / Reverse transcriptase (RNA-dependent DNA polymerase) / Reverse transcriptase domain / Reverse transcriptase (RT) catalytic domain profile. / Retropepsins / Retroviral aspartyl protease / Aspartyl protease, retroviral-type family profile. / Peptidase A2A, retrovirus, catalytic / Retrovirus capsid, C-terminal / Retroviral matrix protein / Retrovirus capsid, N-terminal / zinc finger / Zinc knuckle / Zinc finger, CCHC-type superfamily / Zinc finger, CCHC-type / Zinc finger CCHC-type profile. / Ribonuclease H superfamily / Aspartic peptidase, active site / Eukaryotic and viral aspartyl proteases active site. / Aspartic peptidase domain superfamily / Ribonuclease H-like superfamily / Reverse transcriptase/Diguanylate cyclase domain / DNA/RNA polymerase superfamily / Orthogonal Bundle / Mainly Alpha
Similarity search - Domain/homology
Gag polyprotein / Gag-Pro-Pol polyprotein
Similarity search - Component
Biological speciesHuman T-lymphotropic virus 2
MethodSOLUTION NMR
AuthorsChristensen, A.M. / Massiah, M.A. / Turner, B.G. / Sundquist, W.I. / Summers, M.F.
CitationJournal: J.Mol.Biol. / Year: 1996
Title: Three-dimensional structure of the HTLV-II matrix protein and comparative analysis of matrix proteins from the different classes of pathogenic human retroviruses.
Authors: Christensen, A.M. / Massiah, M.A. / Turner, B.G. / Sundquist, W.I. / Summers, M.F.
History
DepositionOct 3, 1996Processing site: BNL
Revision 1.0Mar 12, 1997Provider: repository / Type: Initial release
Revision 1.1Mar 24, 2008Group: Version format compliance
Revision 1.2Jul 13, 2011Group: Version format compliance
Revision 1.3Feb 23, 2022Group: Database references / Derived calculations / Other
Category: database_2 / pdbx_database_status ...database_2 / pdbx_database_status / pdbx_struct_assembly / pdbx_struct_oper_list / struct_ref_seq_dif
Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession ..._database_2.pdbx_DOI / _database_2.pdbx_database_accession / _pdbx_database_status.process_site / _struct_ref_seq_dif.details

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Structure visualization

Structure viewerMolecule:
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Assembly

Deposited unit
A: HUMAN T-CELL LEUKEMIA VIRUS TYPE II MATRIX PROTEIN


Theoretical massNumber of molelcules
Total (without water)15,0301
Polymers15,0301
Non-polymers00
Water0
1


  • Idetical with deposited unit
  • defined by author
TypeNameSymmetry operationNumber
identity operation1_555x,y,z1
NMR ensembles
DataCriteria
Number of conformers (submitted / calculated)20 / -
Representative

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Components

#1: Protein HUMAN T-CELL LEUKEMIA VIRUS TYPE II MATRIX PROTEIN / HTLV-II MA / MA


Mass: 15030.431 Da / Num. of mol.: 1
Source method: isolated from a genetically manipulated source
Source: (gene. exp.) Human T-lymphotropic virus 2 / Genus: Deltaretrovirus / Species: Primate T-lymphotropic virus 2 / Cell line: BL21 / Plasmid: WISP92-18 / Species (production host): Escherichia coli / Production host: Escherichia coli BL21(DE3) (bacteria) / Strain (production host): BL21 (DE3) / References: UniProt: P03346, UniProt: P03363*PLUS

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Experimental details

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Experiment

ExperimentMethod: SOLUTION NMR

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Sample preparation

Sample conditionspH: 5.5 / Temperature: 308 K
Crystal grow
*PLUS
Method: other / Details: NMR

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Processing

NMR softwareName: DIANA / Developer: GUNTERT,BRAUN,WUTHRICH / Classification: refinement
NMR ensembleConformers submitted total number: 20

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