[English] 日本語
![](img/lk-miru.gif)
- PDB-1ifa: THREE-DIMENSIONAL CRYSTAL STRUCTURE OF RECOMBINANT MURINE INTERFE... -
+
Open data
-
Basic information
Entry | Database: PDB / ID: 1ifa | ||||||
---|---|---|---|---|---|---|---|
Title | THREE-DIMENSIONAL CRYSTAL STRUCTURE OF RECOMBINANT MURINE INTERFERON-BETA | ||||||
![]() | INTERFERON-BETA | ||||||
![]() | GLYCOPROTEIN | ||||||
Function / homology | ![]() negative regulation of Lewy body formation / negative regulation of matrix metallopeptidase secretion / negative regulation of mononuclear cell migration / Regulation of IFNA/IFNB signaling / type I interferon receptor binding / negative regulation of immunoglobulin production / Interferon alpha/beta signaling / natural killer cell activation involved in immune response / negative regulation of blood-brain barrier permeability / positive regulation of peptidyl-serine phosphorylation of STAT protein ...negative regulation of Lewy body formation / negative regulation of matrix metallopeptidase secretion / negative regulation of mononuclear cell migration / Regulation of IFNA/IFNB signaling / type I interferon receptor binding / negative regulation of immunoglobulin production / Interferon alpha/beta signaling / natural killer cell activation involved in immune response / negative regulation of blood-brain barrier permeability / positive regulation of peptidyl-serine phosphorylation of STAT protein / negative regulation of neuroinflammatory response / negative regulation of cell adhesion molecule production / positive regulation of transforming growth factor beta production / T cell activation involved in immune response / macrophage activation involved in immune response / cellular response to dsRNA / type I interferon-mediated signaling pathway / B cell proliferation / response to exogenous dsRNA / negative regulation of osteoclast differentiation / humoral immune response / negative regulation of type II interferon production / positive regulation of autophagy / cellular response to dexamethasone stimulus / B cell differentiation / cytokine activity / cellular response to virus / cytokine-mediated signaling pathway / neuron cellular homeostasis / defense response to virus / adaptive immune response / defense response to bacterium / negative regulation of cell population proliferation / extracellular space / extracellular region Similarity search - Function | ||||||
Biological species | ![]() ![]() | ||||||
Method | ![]() | ||||||
![]() | Mitsui, Y. / Senda, T. / Matsuda, S. / Kawano, G. / Nakamura, K.T. / Shimizu, H. | ||||||
![]() | ![]() Title: Three-dimensional crystal structure of recombinant murine interferon-beta. Authors: Senda, T. / Shimazu, T. / Matsuda, S. / Kawano, G. / Shimizu, H. / Nakamura, K.T. / Mitsui, Y. #1: ![]() Title: Structural, Functional and Evolutionary Implications of the Three-Dimensional Crystal Structure of Murine Interferon-Beta Authors: Mitsui, Y. / Senda, T. / Shimazu, T. / Matsuda, S. / Utsumi, J. #2: ![]() Title: Three-Dimensional Structure of Recombinant Murine Interferon-Beta Authors: Senda, T. / Matsuda, S. / Kurihara, H. / Nakamura, K.T. / Kawano, G. / Shimizu, H. / Mizuno, H. / Mitsui, Y. #3: ![]() Title: New Crystal Form of Recombinant Murine Interferon-Beta Authors: Matsuda, S. / Senda, T. / Itoh, S. / Kawano, G. / Mizuno, H. / Mitsui, Y. | ||||||
History |
|
-
Structure visualization
Structure viewer | Molecule: ![]() ![]() |
---|
-
Downloads & links
-
Download
PDBx/mmCIF format | ![]() | 16.4 KB | Display | ![]() |
---|---|---|---|---|
PDB format | ![]() | 7.3 KB | Display | ![]() |
PDBx/mmJSON format | ![]() | Tree view | ![]() | |
Others | ![]() |
-Validation report
Summary document | ![]() | 297.5 KB | Display | ![]() |
---|---|---|---|---|
Full document | ![]() | 297.5 KB | Display | |
Data in XML | ![]() | 799 B | Display | |
Data in CIF | ![]() | 2.2 KB | Display | |
Arichive directory | ![]() ![]() | HTTPS FTP |
-Related structure data
Similar structure data |
---|
-
Links
-
Assembly
Deposited unit | ![]()
| ||||||||
---|---|---|---|---|---|---|---|---|---|
1 |
| ||||||||
Unit cell |
|
-
Components
#1: Protein | Mass: 19419.561 Da / Num. of mol.: 1 Source method: isolated from a genetically manipulated source Source: (gene. exp.) ![]() ![]() |
---|---|
#2: Chemical | ChemComp-ASN / |
Compound details | AS DEDUCED FROM GENE-MANIPULATING EXPERIMENTS ON THE INTERFERON-ALPHA THE FUNCTIONALLY IMPORTANT ...AS DEDUCED FROM GENE-MANIPULATI |
-Experimental details
-Experiment
Experiment | Method: ![]() |
---|
-
Sample preparation
Crystal | Density Matthews: 3.02 Å3/Da / Density % sol: 59.22 % | ||||||||||||||||||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Crystal grow | *PLUS Temperature: 15 ℃ / pH: 5.3 / Method: vapor diffusion | ||||||||||||||||||||||||||||||||||||
Components of the solutions | *PLUS
|
-Data collection
Radiation | Scattering type: x-ray |
---|---|
Radiation wavelength | Relative weight: 1 |
Reflection | *PLUS Highest resolution: 2.5 Å / Num. obs: 8045 / Num. measured all: 37143 / Rmerge(I) obs: 0.0668 |
-
Processing
Software |
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Refinement | Rfactor Rwork: 0.205 / Rfactor obs: 0.205 / Highest resolution: 2.6 Å | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Refinement step | Cycle: LAST / Highest resolution: 2.6 Å
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Refine LS restraints |
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Refinement | *PLUS Highest resolution: 2.6 Å / Lowest resolution: 8 Å / Num. reflection obs: 5055 / Rfactor obs: 0.205 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Solvent computation | *PLUS | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Displacement parameters | *PLUS | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Refine LS restraints | *PLUS Type: x_angle_d / Dev ideal: 0.059 |