[English] 日本語
Yorodumi- PDB-1hul: A NOVEL DIMER CONFIGURATION REVEALED BY THE CRYSTAL STRUCTURE AT ... -
+Open data
-Basic information
Entry | Database: PDB / ID: 1hul | ||||||
---|---|---|---|---|---|---|---|
Title | A NOVEL DIMER CONFIGURATION REVEALED BY THE CRYSTAL STRUCTURE AT 2.4 ANGSTROMS RESOLUTION OF HUMAN INTERLEUKIN-5 | ||||||
Components | INTERLEUKIN-5Interleukin 5 | ||||||
Keywords | CYTOKINE | ||||||
Function / homology | Function and homology information positive regulation of eosinophil differentiation / interleukin-5 receptor binding / interleukin-5-mediated signaling pathway / positive regulation of podosome assembly / positive regulation of immunoglobulin production / Interleukin-3, Interleukin-5 and GM-CSF signaling / Interleukin receptor SHC signaling / positive regulation of B cell proliferation / cytokine activity / positive regulation of receptor signaling pathway via JAK-STAT ...positive regulation of eosinophil differentiation / interleukin-5 receptor binding / interleukin-5-mediated signaling pathway / positive regulation of podosome assembly / positive regulation of immunoglobulin production / Interleukin-3, Interleukin-5 and GM-CSF signaling / Interleukin receptor SHC signaling / positive regulation of B cell proliferation / cytokine activity / positive regulation of receptor signaling pathway via JAK-STAT / growth factor activity / positive regulation of peptidyl-tyrosine phosphorylation / RAF/MAP kinase cascade / immune response / inflammatory response / positive regulation of DNA-templated transcription / extracellular space / extracellular region Similarity search - Function | ||||||
Biological species | Homo sapiens (human) | ||||||
Method | X-RAY DIFFRACTION / Resolution: 2.4 Å | ||||||
Authors | Milburn, M.V. | ||||||
Citation | Journal: Nature / Year: 1993 Title: A novel dimer configuration revealed by the crystal structure at 2.4 A resolution of human interleukin-5. Authors: Milburn, M.V. / Hassell, A.M. / Lambert, M.H. / Jordan, S.R. / Proudfoot, A.E. / Graber, P. / Wells, T.N. | ||||||
History |
|
-Structure visualization
Structure viewer | Molecule: MolmilJmol/JSmol |
---|
-Downloads & links
-Download
PDBx/mmCIF format | 1hul.cif.gz | 49.5 KB | Display | PDBx/mmCIF format |
---|---|---|---|---|
PDB format | pdb1hul.ent.gz | 40 KB | Display | PDB format |
PDBx/mmJSON format | 1hul.json.gz | Tree view | PDBx/mmJSON format | |
Others | Other downloads |
-Validation report
Arichive directory | https://data.pdbj.org/pub/pdb/validation_reports/hu/1hul ftp://data.pdbj.org/pub/pdb/validation_reports/hu/1hul | HTTPS FTP |
---|
-Related structure data
Similar structure data |
---|
-Links
-Assembly
Deposited unit |
| ||||||||
---|---|---|---|---|---|---|---|---|---|
1 |
| ||||||||
Unit cell |
|
-Components
#1: Protein | Mass: 12396.356 Da / Num. of mol.: 2 Source method: isolated from a genetically manipulated source Source: (gene. exp.) Homo sapiens (human) / Production host: Escherichia coli (E. coli) / References: UniProt: P05113 #2: Water | ChemComp-HOH / | |
---|
-Experimental details
-Experiment
Experiment | Method: X-RAY DIFFRACTION |
---|
-Sample preparation
Crystal | Density Matthews: 2.48 Å3/Da / Density % sol: 50.4 % | ||||||||||||||||||||||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Crystal grow | *PLUS Temperature: 22 ℃ / pH: 8.5 / Method: vapor diffusion, hanging drop | ||||||||||||||||||||||||||||||||||||||||
Components of the solutions | *PLUS
|
-Data collection
Radiation | Scattering type: x-ray |
---|---|
Radiation wavelength | Relative weight: 1 |
Reflection | Num. obs: 8934 / Observed criterion σ(I): 1 |
Reflection | *PLUS Highest resolution: 2.4 Å / Rmerge(I) obs: 0.065 |
-Processing
Software |
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Refinement | Resolution: 2.4→8 Å / σ(F): 0
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Refinement step | Cycle: LAST / Resolution: 2.4→8 Å
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Refine LS restraints |
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Refinement | *PLUS | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Solvent computation | *PLUS | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Displacement parameters | *PLUS |