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- PDB-1hsq: SOLUTION STRUCTURE OF THE SH3 DOMAIN OF PHOSPHOLIPASE CGAMMA -

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Entry
Database: PDB / ID: 1hsq
TitleSOLUTION STRUCTURE OF THE SH3 DOMAIN OF PHOSPHOLIPASE CGAMMA
ComponentsPHOSPHOLIPASE C-GAMMA (SH3 DOMAIN)
KeywordsPHOSPHORIC DIESTER HYDROLASE
Function / homology
Function and homology information


Activated NTRK3 signals through PLCG1 / Activated NTRK2 signals through PLCG1 / calcium-dependent phospholipase C activity / PLC-gamma1 signalling / DAG and IP3 signaling / phosphoinositide phospholipase C / Role of second messengers in netrin-1 signaling / Phospholipase C-mediated cascade; FGFR3 / phosphatidylinositol metabolic process / Phospholipase C-mediated cascade; FGFR2 ...Activated NTRK3 signals through PLCG1 / Activated NTRK2 signals through PLCG1 / calcium-dependent phospholipase C activity / PLC-gamma1 signalling / DAG and IP3 signaling / phosphoinositide phospholipase C / Role of second messengers in netrin-1 signaling / Phospholipase C-mediated cascade; FGFR3 / phosphatidylinositol metabolic process / Phospholipase C-mediated cascade; FGFR2 / Phospholipase C-mediated cascade; FGFR4 / Erythropoietin activates Phospholipase C gamma (PLCG) / COP9 signalosome / phospholipase C activity / Phospholipase C-mediated cascade: FGFR1 / neurotrophin TRKA receptor binding / phosphatidylinositol-4,5-bisphosphate phospholipase C activity / phospholipid catabolic process / positive regulation of vascular endothelial cell proliferation / EGFR interacts with phospholipase C-gamma / Signaling by ALK / PLCG1 events in ERBB2 signaling / phosphatidylinositol-mediated signaling / Fc-epsilon receptor signaling pathway / Synthesis of IP3 and IP4 in the cytosol / PECAM1 interactions / RET signaling / Generation of second messenger molecules / positive regulation of epithelial cell migration / positive regulation of endothelial cell apoptotic process / positive regulation of blood vessel endothelial cell migration / Role of phospholipids in phagocytosis / Signaling by FGFR4 in disease / Signaling by FGFR3 in disease / ruffle / Signaling by FGFR2 in disease / release of sequestered calcium ion into cytosol / Signaling by FGFR1 in disease / FCERI mediated Ca+2 mobilization / Downstream signal transduction / FCGR3A-mediated IL10 synthesis / cellular response to epidermal growth factor stimulus / guanyl-nucleotide exchange factor activity / positive regulation of release of sequestered calcium ion into cytosol / VEGFR2 mediated cell proliferation / cell projection / FCERI mediated MAPK activation / negative regulation of inflammatory response to antigenic stimulus / calcium-mediated signaling / Signaling by ERBB2 TMD/JMD mutants / Constitutive Signaling by EGFRvIII / Signaling by ERBB2 ECD mutants / Signaling by ERBB2 KD Mutants / ISG15 antiviral mechanism / ruffle membrane / epidermal growth factor receptor signaling pathway / positive regulation of angiogenesis / Signaling by ALK fusions and activated point mutants / DAP12 signaling / cell migration / T cell receptor signaling pathway / lamellipodium / Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants / calcium ion binding / protein kinase binding / plasma membrane / cytoplasm / cytosol
Similarity search - Function
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1, SH3 domain / PLCG EF-hand motif 1 / Phosphatidylinositol-4, 5-bisphosphate phosphodiesterase gamma / PLC-gamma, C-terminal SH2 domain / PLC-gamma, N-terminal SH2 domain / : / PLCG EF-hand motif 2 / Phosphoinositide phospholipase C family / Phospholipase C, phosphatidylinositol-specific, Y domain / Phosphatidylinositol-specific phospholipase C, Y domain ...1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1, SH3 domain / PLCG EF-hand motif 1 / Phosphatidylinositol-4, 5-bisphosphate phosphodiesterase gamma / PLC-gamma, C-terminal SH2 domain / PLC-gamma, N-terminal SH2 domain / : / PLCG EF-hand motif 2 / Phosphoinositide phospholipase C family / Phospholipase C, phosphatidylinositol-specific, Y domain / Phosphatidylinositol-specific phospholipase C, Y domain / Phosphatidylinositol-specific phospholipase Y-box domain profile. / Phospholipase C, catalytic domain (part); domain Y / Phosphatidylinositol-specific phospholipase C, X domain / Phosphatidylinositol-specific phospholipase C, X domain / Phospholipase C, catalytic domain (part); domain X / Phosphatidylinositol-specific phospholipase X-box domain profile. / PLC-like phosphodiesterase, TIM beta/alpha-barrel domain superfamily / Protein kinase C conserved region 2 (CalB) / C2 domain / C2 domain / C2 domain profile. / SH3 Domains / PH domain / C2 domain superfamily / PH domain profile. / Pleckstrin homology domain. / Pleckstrin homology domain / SH3 domain / SH2 domain / Src homology 2 (SH2) domain profile. / Src homology 2 domains / SH2 domain / SH3 type barrels. / Src homology 3 domains / SH2 domain superfamily / SH3-like domain superfamily / EF-Hand 1, calcium-binding site / Src homology 3 (SH3) domain profile. / SH3 domain / EF-hand calcium-binding domain. / EF-hand calcium-binding domain profile. / EF-hand domain / EF-hand domain pair / PH-like domain superfamily / Roll / Mainly Beta
Similarity search - Domain/homology
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1
Similarity search - Component
Biological speciesHomo sapiens (human)
MethodSOLUTION NMR
AuthorsKohda, D. / Hatanaka, H. / Odaka, M. / Inagaki, F.
Citation
Journal: Cell(Cambridge,Mass.) / Year: 1993
Title: Solution structure of the SH3 domain of phospholipase C-gamma.
Authors: Kohda, D. / Hatanaka, H. / Odaka, M. / Mandiyan, V. / Ullrich, A. / Schlessinger, J. / Inagaki, F.
#1: Journal: Structure / Year: 1994
Title: Solution Structure and Ligand-Binding Site of the C-Terminal SH3 Domain of Grb2
Authors: Kohda, D. / Terasawa, H. / Ichikawa, S. / Ogura, K. / Hatanaka, H. / Mandiyan, V. / Ullrich, A. / Schlessinger, J. / Inagaki, F.
History
DepositionJun 13, 1994Processing site: BNL
Revision 1.0Aug 31, 1994Provider: repository / Type: Initial release
Revision 1.1Mar 24, 2008Group: Version format compliance
Revision 1.2Jul 13, 2011Group: Version format compliance
Revision 1.3Nov 29, 2017Group: Derived calculations / Other
Category: pdbx_database_status / pdbx_struct_assembly ...pdbx_database_status / pdbx_struct_assembly / pdbx_struct_oper_list / struct_conf / struct_conf_type
Item: _pdbx_database_status.process_site
Revision 1.4May 1, 2024Group: Data collection / Database references / Category: chem_comp_atom / chem_comp_bond / database_2
Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession

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Structure visualization

Structure viewerMolecule:
MolmilJmol/JSmol

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Assembly

Deposited unit
A: PHOSPHOLIPASE C-GAMMA (SH3 DOMAIN)


Theoretical massNumber of molelcules
Total (without water)8,2491
Polymers8,2491
Non-polymers00
Water00
1


  • Idetical with deposited unit
  • defined by author
TypeNameSymmetry operationNumber
identity operation1_5551
Atom site foot note1: A BETA-BULGE STRUCTURE OCCURS AT LYS 50 - GLN 51 - LEU 52.
NMR ensembles
DataCriteria
Number of conformers (submitted / calculated)1 / -
Representative

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Components

#1: Protein PHOSPHOLIPASE C-GAMMA (SH3 DOMAIN)


Mass: 8249.244 Da / Num. of mol.: 1
Source method: isolated from a genetically manipulated source
Source: (gene. exp.) Homo sapiens (human) / Gene: GRB2
References: UniProt: P19174, phosphoinositide phospholipase C

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Experimental details

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Experiment

ExperimentMethod: SOLUTION NMR

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Sample preparation

Crystal grow
*PLUS
Method: other / Details: NMR

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Processing

Software
NameClassification
X-PLORmodel building
X-PLORrefinement
X-PLORphasing
NMR software
NameDeveloperClassification
DSPACENILGESrefinement
X-PLORBRUNGERrefinement
NMR ensembleConformers submitted total number: 1

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