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Open data
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Basic information
Entry | Database: PDB / ID: 1hsq | ||||||
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Title | SOLUTION STRUCTURE OF THE SH3 DOMAIN OF PHOSPHOLIPASE CGAMMA | ||||||
![]() | PHOSPHOLIPASE C-GAMMA (SH3 DOMAIN) | ||||||
![]() | PHOSPHORIC DIESTER HYDROLASE | ||||||
Function / homology | ![]() Activated NTRK3 signals through PLCG1 / Activated NTRK2 signals through PLCG1 / calcium-dependent phospholipase C activity / PLC-gamma1 signalling / Role of second messengers in netrin-1 signaling / phosphoinositide phospholipase C / DAG and IP3 signaling / phospholipid catabolic process / phosphatidylinositol metabolic process / Phospholipase C-mediated cascade; FGFR3 ...Activated NTRK3 signals through PLCG1 / Activated NTRK2 signals through PLCG1 / calcium-dependent phospholipase C activity / PLC-gamma1 signalling / Role of second messengers in netrin-1 signaling / phosphoinositide phospholipase C / DAG and IP3 signaling / phospholipid catabolic process / phosphatidylinositol metabolic process / Phospholipase C-mediated cascade; FGFR3 / Phospholipase C-mediated cascade; FGFR2 / phosphatidylinositol phospholipase C activity / Phospholipase C-mediated cascade; FGFR4 / Erythropoietin activates Phospholipase C gamma (PLCG) / COP9 signalosome / phospholipase C activity / Phospholipase C-mediated cascade: FGFR1 / neurotrophin TRKA receptor binding / positive regulation of endothelial cell apoptotic process / EGFR interacts with phospholipase C-gamma / positive regulation of vascular endothelial cell proliferation / PLCG1 events in ERBB2 signaling / Signaling by ALK / positive regulation of epithelial cell migration / Synthesis of IP3 and IP4 in the cytosol / PECAM1 interactions / Fc-epsilon receptor signaling pathway / phosphatidylinositol-mediated signaling / Generation of second messenger molecules / RET signaling / positive regulation of blood vessel endothelial cell migration / Role of phospholipids in phagocytosis / glutamate receptor binding / Signaling by FGFR4 in disease / release of sequestered calcium ion into cytosol / negative regulation of inflammatory response to antigenic stimulus / Signaling by FGFR3 in disease / cellular response to epidermal growth factor stimulus / ruffle / Signaling by FGFR2 in disease / Signaling by FGFR1 in disease / Downstream signal transduction / FCERI mediated Ca+2 mobilization / FCGR3A-mediated IL10 synthesis / guanyl-nucleotide exchange factor activity / positive regulation of release of sequestered calcium ion into cytosol / VEGFR2 mediated cell proliferation / cell projection / calcium-mediated signaling / FCERI mediated MAPK activation / Signaling by ERBB2 TMD/JMD mutants / Schaffer collateral - CA1 synapse / Constitutive Signaling by EGFRvIII / modulation of chemical synaptic transmission / Signaling by ERBB2 ECD mutants / Signaling by ERBB2 KD Mutants / epidermal growth factor receptor signaling pathway / receptor tyrosine kinase binding / ISG15 antiviral mechanism / ruffle membrane / positive regulation of angiogenesis / cell-cell junction / Signaling by ALK fusions and activated point mutants / cell migration / lamellipodium / Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants / DAP12 signaling / T cell receptor signaling pathway / in utero embryonic development / glutamatergic synapse / calcium ion binding / protein kinase binding / plasma membrane / cytoplasm / cytosol Similarity search - Function | ||||||
Biological species | ![]() | ||||||
Method | SOLUTION NMR | ||||||
![]() | Kohda, D. / Hatanaka, H. / Odaka, M. / Inagaki, F. | ||||||
![]() | ![]() Title: Solution structure of the SH3 domain of phospholipase C-gamma. Authors: Kohda, D. / Hatanaka, H. / Odaka, M. / Mandiyan, V. / Ullrich, A. / Schlessinger, J. / Inagaki, F. #1: ![]() Title: Solution Structure and Ligand-Binding Site of the C-Terminal SH3 Domain of Grb2 Authors: Kohda, D. / Terasawa, H. / Ichikawa, S. / Ogura, K. / Hatanaka, H. / Mandiyan, V. / Ullrich, A. / Schlessinger, J. / Inagaki, F. | ||||||
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Structure visualization
Structure viewer | Molecule: ![]() ![]() |
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Downloads & links
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Download
PDBx/mmCIF format | ![]() | 37 KB | Display | ![]() |
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PDB format | ![]() | 24.9 KB | Display | ![]() |
PDBx/mmJSON format | ![]() | Tree view | ![]() | |
Others | ![]() |
-Validation report
Summary document | ![]() | 343.6 KB | Display | ![]() |
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Full document | ![]() | 349.8 KB | Display | |
Data in XML | ![]() | 3.9 KB | Display | |
Data in CIF | ![]() | 4.8 KB | Display | |
Arichive directory | ![]() ![]() | HTTPS FTP |
-Related structure data
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Links
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Assembly
Deposited unit | ![]()
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1 |
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Atom site foot note | 1: A BETA-BULGE STRUCTURE OCCURS AT LYS 50 - GLN 51 - LEU 52. | |||||||||
NMR ensembles |
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Components
#1: Protein | Mass: 8249.244 Da / Num. of mol.: 1 Source method: isolated from a genetically manipulated source Source: (gene. exp.) ![]() References: UniProt: P19174, phosphoinositide phospholipase C |
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-Experimental details
-Experiment
Experiment | Method: SOLUTION NMR |
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Sample preparation
Crystal grow | *PLUS Method: other / Details: NMR |
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NMR ensemble | Conformers submitted total number: 1 |