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- PDB-1hom: DETERMINATION OF THE THREE-DIMENSIONAL STRUCTURE OF THE ANTENNAPE... -

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Entry
Database: PDB / ID: 1hom
TitleDETERMINATION OF THE THREE-DIMENSIONAL STRUCTURE OF THE ANTENNAPEDIA HOMEODOMAIN FROM DROSOPHILA IN SOLUTION BY 1H NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY
ComponentsANTENNAPEDIA PROTEIN
KeywordsDNA BINDING PROTEIN / DNA-BINDING PROTEIN
Function / homology
Function and homology information


specification of segmental identity, antennal segment / specification of segmental identity, thorax / neuroblast development / muscle cell fate specification / lymph gland development / ventral cord development / midgut development / anterior/posterior axis specification / anterior/posterior pattern specification / regulation of neurogenesis ...specification of segmental identity, antennal segment / specification of segmental identity, thorax / neuroblast development / muscle cell fate specification / lymph gland development / ventral cord development / midgut development / anterior/posterior axis specification / anterior/posterior pattern specification / regulation of neurogenesis / heart development / sequence-specific DNA binding / DNA-binding transcription factor activity, RNA polymerase II-specific / RNA polymerase II cis-regulatory region sequence-specific DNA binding / negative regulation of transcription by RNA polymerase II / positive regulation of transcription by RNA polymerase II / DNA binding / nucleus / cytoplasm
Similarity search - Function
Homeobox protein, antennapedia type / Homeobox protein, antennapedia type, conserved site / 'Homeobox' antennapedia-type protein signature. / : / Homeobox domain, metazoa / Homeobox, conserved site / 'Homeobox' domain signature. / Homeodomain / 'Homeobox' domain profile. / Homeodomain ...Homeobox protein, antennapedia type / Homeobox protein, antennapedia type, conserved site / 'Homeobox' antennapedia-type protein signature. / : / Homeobox domain, metazoa / Homeobox, conserved site / 'Homeobox' domain signature. / Homeodomain / 'Homeobox' domain profile. / Homeodomain / Homeobox domain / Homeodomain-like / Homeobox-like domain superfamily / Arc Repressor Mutant, subunit A / Orthogonal Bundle / Mainly Alpha
Similarity search - Domain/homology
Homeotic protein antennapedia
Similarity search - Component
Biological speciesDrosophila melanogaster (fruit fly)
MethodSOLUTION NMR
AuthorsQian, Y.-Q. / Billeter, M. / Otting, G. / Muller, M. / Gehring, W.J. / Wuthrich, K.
Citation
Journal: J.Mol.Biol. / Year: 1990
Title: Determination of the three-dimensional structure of the Antennapedia homeodomain from Drosophila in solution by 1H nuclear magnetic resonance spectroscopy.
Authors: Billeter, M. / Qian, Y. / Otting, G. / Muller, M. / Gehring, W.J. / Wuthrich, K.
#1: Journal: Cell(Cambridge,Mass.) / Year: 1989
Title: The Structure of the Antennapedia Homeodomain Determined by NMR Spectroscopy in Solution: Comparison with Prokaryotic Repressors
Authors: Qian, Y.Q. / Billeter, M. / Otting, G. / Mueller, M. / Gehring, W.J. / Wuthrich, K.
#2: Journal: Embo J. / Year: 1988
Title: Secondary Structure Determination for the Antennapedia Homeodomain by Nuclear Magnetic Resonance and Evidence for a Helix-Turn-Helix Motif
Authors: Otting, G. / Qian, Y.-Q. / Mueller, M. / Affolter, M. / Gehring, W.J. / Wuthrich, K.
History
DepositionOct 8, 1991Processing site: BNL
Revision 1.0Oct 31, 1993Provider: repository / Type: Initial release
Revision 1.1Mar 24, 2008Group: Version format compliance
Revision 1.2Jul 13, 2011Group: Version format compliance
Revision 1.3Feb 23, 2022Group: Data collection / Database references ...Data collection / Database references / Derived calculations / Other / Structure summary
Category: database_2 / pdbx_database_status ...database_2 / pdbx_database_status / pdbx_nmr_software / pdbx_struct_assembly / pdbx_struct_oper_list / struct_keywords
Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession ..._database_2.pdbx_DOI / _database_2.pdbx_database_accession / _pdbx_database_status.process_site / _pdbx_nmr_software.name / _struct_keywords.text
Revision 1.4May 22, 2024Group: Data collection / Category: chem_comp_atom / chem_comp_bond

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Structure visualization

Structure viewerMolecule:
MolmilJmol/JSmol

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Assembly

Deposited unit
A: ANTENNAPEDIA PROTEIN


Theoretical massNumber of molelcules
Total (without water)8,6771
Polymers8,6771
Non-polymers00
Water00
1


  • Idetical with deposited unit
  • defined by author
TypeNameSymmetry operationNumber
identity operation1_555x,y,z1
NMR ensembles
DataCriteria
Number of conformers (submitted / calculated)19 / -
Representative

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Components

#1: Protein ANTENNAPEDIA PROTEIN


Mass: 8677.159 Da / Num. of mol.: 1
Source method: isolated from a genetically manipulated source
Source: (gene. exp.) Drosophila melanogaster (fruit fly) / Production host: Escherichia coli (E. coli) / References: UniProt: P02833

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Experimental details

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Experiment

ExperimentMethod: SOLUTION NMR

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Sample preparation

Crystal grow
*PLUS
Method: other / Details: NMR

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Processing

NMR software
NameVersionDeveloperClassification
DISMANBRAUN,GOrefinement
Amber3SINGH,WEINER,CALDWELL,KOLLMANrefinement
NMR ensembleConformers submitted total number: 19

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