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- PDB-1hkt: SOLUTION STRUCTURE OF THE DNA-BINDING DOMAIN OF DROSOPHILA HEAT S... -

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Entry
Database: PDB / ID: 1hkt
TitleSOLUTION STRUCTURE OF THE DNA-BINDING DOMAIN OF DROSOPHILA HEAT SHOCK TRANSCRIPTION FACTOR
ComponentsHEAT-SHOCK TRANSCRIPTION FACTOR
KeywordsTRANSCRIPTION REGULATION
Function / homology
Function and homology information


Regulation of HSF1-mediated heat shock response / Attenuation phase / Mitochondrial unfolded protein response (UPRmt) / HSF1 activation / HSF1-dependent transactivation / polytene chromosome / defense response to fungus / response to heat / sequence-specific DNA binding / defense response to bacterium ...Regulation of HSF1-mediated heat shock response / Attenuation phase / Mitochondrial unfolded protein response (UPRmt) / HSF1 activation / HSF1-dependent transactivation / polytene chromosome / defense response to fungus / response to heat / sequence-specific DNA binding / defense response to bacterium / DNA-binding transcription factor activity / negative regulation of DNA-templated transcription / chromatin / positive regulation of DNA-templated transcription / positive regulation of transcription by RNA polymerase II / DNA binding / identical protein binding / nucleus
Similarity search - Function
Vertebrate heat shock transcription factor, C-terminal domain / Vertebrate heat shock transcription factor / HSF-type DNA-binding domain signature. / Heat shock factor (HSF)-type, DNA-binding / HSF-type DNA-binding / heat shock factor / Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain / Arc Repressor Mutant, subunit A / Winged helix DNA-binding domain superfamily / Winged helix-like DNA-binding domain superfamily ...Vertebrate heat shock transcription factor, C-terminal domain / Vertebrate heat shock transcription factor / HSF-type DNA-binding domain signature. / Heat shock factor (HSF)-type, DNA-binding / HSF-type DNA-binding / heat shock factor / Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain / Arc Repressor Mutant, subunit A / Winged helix DNA-binding domain superfamily / Winged helix-like DNA-binding domain superfamily / Orthogonal Bundle / Mainly Alpha
Similarity search - Domain/homology
Heat shock factor protein
Similarity search - Component
Biological speciesDrosophila melanogaster (fruit fly)
MethodSOLUTION NMR
AuthorsVuister, G.W. / Kim, S.-J. / Orosz, A. / Marquardt, J.L. / Wu, C. / Bax, A.
Citation
Journal: Nat.Struct.Biol. / Year: 1994
Title: Solution structure of the DNA-binding domain of Drosophila heat shock transcription factor.
Authors: Vuister, G.W. / Kim, S.J. / Orosz, A. / Marquardt, J. / Wu, C. / Bax, A.
#1: Journal: Biochemistry / Year: 1994
Title: NMR Evidence for Similarities between the DNA-Binding Regions of Drosophila Melanogaster Heat Shock Factor and the Helix-Turn-Helix and HNF-3(Slash)Forkhead Families of Transcription Factors
Authors: Vuister, G.W. / Kim, S.-J. / Wu, C. / Bax, A.
History
DepositionJul 18, 1994Processing site: BNL
Revision 1.0Sep 30, 1994Provider: repository / Type: Initial release
Revision 1.1Mar 24, 2008Group: Version format compliance
Revision 1.2Jul 13, 2011Group: Version format compliance
Revision 1.3Feb 23, 2022Group: Database references / Derived calculations / Other
Category: database_2 / pdbx_database_status ...database_2 / pdbx_database_status / pdbx_struct_assembly / pdbx_struct_oper_list
Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _pdbx_database_status.process_site
Revision 1.4May 22, 2024Group: Data collection / Category: chem_comp_atom / chem_comp_bond

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Assembly

Deposited unit
A: HEAT-SHOCK TRANSCRIPTION FACTOR


Theoretical massNumber of molelcules
Total (without water)12,4091
Polymers12,4091
Non-polymers00
Water00
1


  • Idetical with deposited unit
  • defined by author
TypeNameSymmetry operationNumber
identity operation1_555x,y,z1
NMR ensembles
DataCriteria
Number of conformers (submitted / calculated)28 / -
Representative

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Components

#1: Protein HEAT-SHOCK TRANSCRIPTION FACTOR


Mass: 12409.178 Da / Num. of mol.: 1
Source method: isolated from a genetically manipulated source
Source: (gene. exp.) Drosophila melanogaster (fruit fly) / References: UniProt: P22813

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Experimental details

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Experiment

ExperimentMethod: SOLUTION NMR

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Sample preparation

Crystal grow
*PLUS
Method: other / Details: NMR

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Processing

NMR ensembleConformers submitted total number: 28

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