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- PDB-1hae: HEREGULIN-ALPHA EPIDERMAL GROWTH FACTOR-LIKE DOMAIN, NMR, 20 STRU... -

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Basic information

Entry
Database: PDB / ID: 1hae
TitleHEREGULIN-ALPHA EPIDERMAL GROWTH FACTOR-LIKE DOMAIN, NMR, 20 STRUCTURES
ComponentsHEREGULIN-ALPHA
KeywordsGROWTH FACTOR
Function / homology
Function and homology information


ERBB3 signaling pathway / positive regulation of peptidyl-tyrosine autophosphorylation / sequestering of metal ion / ERBB4 signaling pathway / ERBB4-ERBB4 signaling pathway / ventricular cardiac muscle cell differentiation / positive regulation of striated muscle cell differentiation / negative regulation of secretion / animal organ development / endocardial cell differentiation ...ERBB3 signaling pathway / positive regulation of peptidyl-tyrosine autophosphorylation / sequestering of metal ion / ERBB4 signaling pathway / ERBB4-ERBB4 signaling pathway / ventricular cardiac muscle cell differentiation / positive regulation of striated muscle cell differentiation / negative regulation of secretion / animal organ development / endocardial cell differentiation / ERBB2-ERBB4 signaling pathway / GRB7 events in ERBB2 signaling / neural crest cell development / cardiac muscle cell myoblast differentiation / cell communication / PI3K events in ERBB4 signaling / cardiac muscle cell differentiation / mammary gland development / chemorepellent activity / ventricular trabecula myocardium morphogenesis / ErbB-3 class receptor binding / regulation of postsynaptic neurotransmitter receptor internalization / ERBB signaling pathway / activation of transmembrane receptor protein tyrosine kinase activity / negative regulation of cardiac muscle cell apoptotic process / ERBB2 Activates PTK6 Signaling / ERBB2-ERBB3 signaling pathway / transmembrane receptor protein tyrosine kinase activator activity / protein tyrosine kinase activator activity / Signaling by ERBB4 / ERBB2 Regulates Cell Motility / Long-term potentiation / PI3K events in ERBB2 signaling / positive regulation of cell adhesion / negative regulation of extrinsic apoptotic signaling pathway in absence of ligand / SHC1 events in ERBB4 signaling / Nuclear signaling by ERBB4 / positive regulation of cardiac muscle cell proliferation / Signaling by ERBB2 / cell surface receptor protein tyrosine kinase signaling pathway / Downregulation of ERBB2:ERBB3 signaling / GRB2 events in ERBB2 signaling / activation of protein kinase B activity / SHC1 events in ERBB2 signaling / cytokine activity / transcription coregulator activity / Signaling by ERBB2 TMD/JMD mutants / growth factor activity / wound healing / positive regulation of protein-containing complex assembly / Signaling by ERBB2 KD Mutants / receptor tyrosine kinase binding / Downregulation of ERBB2 signaling / Constitutive Signaling by Aberrant PI3K in Cancer / integrin binding / PIP3 activates AKT signaling / nervous system development / PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling / RAF/MAP kinase cascade / positive regulation of cell growth / cell population proliferation / receptor ligand activity / cell differentiation / positive regulation of ERK1 and ERK2 cascade / intracellular signal transduction / apical plasma membrane / signaling receptor binding / negative regulation of DNA-templated transcription / glutamatergic synapse / positive regulation of cell population proliferation / extracellular space / extracellular region / nucleoplasm / membrane / plasma membrane
Similarity search - Function
Neuregulin, C-terminal / Neuregulin-1 / Neuregulin / Neuregulin intracellular region / Laminin / Laminin / EGF-like domain / Immunoglobulin I-set / Immunoglobulin I-set domain / Epidermal growth factor-like domain. ...Neuregulin, C-terminal / Neuregulin-1 / Neuregulin / Neuregulin intracellular region / Laminin / Laminin / EGF-like domain / Immunoglobulin I-set / Immunoglobulin I-set domain / Epidermal growth factor-like domain. / EGF-like domain profile. / EGF-like domain signature 2. / EGF-like domain signature 1. / EGF-like domain / Immunoglobulin subtype 2 / Immunoglobulin C-2 Type / Ribbon / Immunoglobulin subtype / Immunoglobulin / Ig-like domain profile. / Immunoglobulin-like domain / Immunoglobulin-like domain superfamily / Immunoglobulin-like fold / Mainly Beta
Similarity search - Domain/homology
Pro-neuregulin-1, membrane-bound isoform
Similarity search - Component
Biological speciesHomo sapiens (human)
MethodSOLUTION NMR
AuthorsJacobsen, N.E. / Skelton, N.J. / Fairbrother, W.J.
Citation
Journal: Biochemistry / Year: 1996
Title: High-resolution solution structure of the EGF-like domain of heregulin-alpha.
Authors: Jacobsen, N.E. / Abadi, N. / Sliwkowski, M.X. / Reilly, D. / Skelton, N.J. / Fairbrother, W.J.
#1: Journal: Science / Year: 1992
Title: Identification of Heregulin, a Specific Activator of P185Erbb2
Authors: Holmes, W.E. / Sliwkowski, M.X. / Akita, R.W. / Henzel, W.J. / Lee, J. / Park, J.W. / Yansura, D. / Abadi, N. / Raab, H. / Lewis, G.D. / al., et
History
DepositionNov 30, 1995Processing site: BNL
Revision 1.0Jul 11, 1996Provider: repository / Type: Initial release
Revision 1.1Mar 24, 2008Group: Version format compliance
Revision 1.2Jul 13, 2011Group: Version format compliance
Revision 1.3Feb 23, 2022Group: Data collection / Database references ...Data collection / Database references / Derived calculations / Other
Category: database_2 / pdbx_database_status ...database_2 / pdbx_database_status / pdbx_nmr_software / pdbx_struct_assembly / pdbx_struct_oper_list
Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession ..._database_2.pdbx_DOI / _database_2.pdbx_database_accession / _pdbx_database_status.process_site / _pdbx_nmr_software.name

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Structure visualization

Structure viewerMolecule:
MolmilJmol/JSmol

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Assembly

Deposited unit
A: HEREGULIN-ALPHA


Theoretical massNumber of molelcules
Total (without water)7,1291
Polymers7,1291
Non-polymers00
Water00
1


  • Idetical with deposited unit
  • defined by author
TypeNameSymmetry operationNumber
identity operation1_555x,y,z1
NMR ensembles
DataCriteria
Number of conformers (submitted / calculated)20 / -
Representative

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Components

#1: Protein HEREGULIN-ALPHA / NEU DIFFERENTIATION FACTOR (RAT) / ACETYLCHOLINE RECEPTOR INDUCING ACTIVITY (CHICKEN) / GLIAL ...NEU DIFFERENTIATION FACTOR (RAT) / ACETYLCHOLINE RECEPTOR INDUCING ACTIVITY (CHICKEN) / GLIAL GROWTH FACTOR (HUMAN) / NEUREGULIN


Mass: 7129.222 Da / Num. of mol.: 1 / Fragment: EPIDERMAL GROWTH FACTOR-LIKE DOMAIN
Source method: isolated from a genetically manipulated source
Source: (gene. exp.) Homo sapiens (human) / Production host: Escherichia coli (E. coli) / References: UniProt: Q02297

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Experimental details

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Experiment

ExperimentMethod: SOLUTION NMR

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Sample preparation

Sample conditionspH: 4.5 / Temperature: 293 K
Crystal grow
*PLUS
Method: other / Details: NMR

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Processing

SoftwareName: AMBER / Classification: refinement
NMR softwareName: Discover / Developer: BIOSYM TECHNOLOGIES / Classification: refinement
NMR ensembleConformers submitted total number: 20

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