登録情報 | データベース: PDB / ID: 1h59 |
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タイトル | Complex of IGFBP-5 with IGF-I |
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要素 | - INSULIN-LIKE GROWTH FACTOR BINDING PROTEIN 5
- INSULIN-LIKE GROWTH FACTOR IA
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キーワード | INSULIN / INSULIN-LIKE GROWTH FACTOR / IGF BINDING PROTEIN |
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機能・相同性 | 機能・相同性情報
negative regulation of muscle tissue development / negative regulation of skeletal muscle hypertrophy / regulation of insulin-like growth factor receptor signaling pathway / glycolate metabolic process / muscle hypertrophy / negative regulation of oocyte development / positive regulation of trophectodermal cell proliferation / insulin-like growth factor binding protein complex / insulin-like growth factor ternary complex / negative regulation of insulin-like growth factor receptor signaling pathway ...negative regulation of muscle tissue development / negative regulation of skeletal muscle hypertrophy / regulation of insulin-like growth factor receptor signaling pathway / glycolate metabolic process / muscle hypertrophy / negative regulation of oocyte development / positive regulation of trophectodermal cell proliferation / insulin-like growth factor binding protein complex / insulin-like growth factor ternary complex / negative regulation of insulin-like growth factor receptor signaling pathway / proteoglycan biosynthetic process / negative regulation of smooth muscle cell migration / positive regulation of glycoprotein biosynthetic process / myotube cell development / skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration / negative regulation of neuroinflammatory response / mammary gland involution / bone mineralization involved in bone maturation / Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) / positive regulation of cell growth involved in cardiac muscle cell development / negative regulation of vascular associated smooth muscle cell apoptotic process / IRS-related events triggered by IGF1R / negative regulation of growth / exocytic vesicle / cell activation / positive regulation of calcineurin-NFAT signaling cascade / insulin-like growth factor II binding / type B pancreatic cell proliferation / positive regulation of transcription regulatory region DNA binding / insulin-like growth factor I binding / alphav-beta3 integrin-IGF-1-IGF1R complex / positive regulation of Ras protein signal transduction / positive regulation of vascular associated smooth muscle cell migration / response to growth hormone / myoblast differentiation / positive regulation of insulin-like growth factor receptor signaling pathway / myoblast proliferation / muscle organ development / negative regulation of interleukin-1 beta production / hair follicle morphogenesis / lung alveolus development / positive regulation of cardiac muscle hypertrophy / positive regulation of smooth muscle cell migration / positive regulation of activated T cell proliferation / negative regulation of release of cytochrome c from mitochondria / negative regulation of amyloid-beta formation / negative regulation of smooth muscle cell apoptotic process / fibronectin binding / cellular response to organic cyclic compound / negative regulation of tumor necrosis factor production / positive regulation of glycogen biosynthetic process / Synthesis, secretion, and deacylation of Ghrelin / epithelial to mesenchymal transition / negative regulation of osteoblast differentiation / SHC-related events triggered by IGF1R / positive regulation of DNA binding / positive regulation of osteoblast differentiation / cellular response to cAMP / positive regulation of tyrosine phosphorylation of STAT protein / positive regulation of vascular associated smooth muscle cell proliferation / striated muscle cell differentiation / positive regulation of glycolytic process / activation of protein kinase B activity / positive regulation of mitotic nuclear division / negative regulation of cell migration / insulin-like growth factor receptor signaling pathway / platelet alpha granule lumen / skeletal system development / positive regulation of epithelial cell proliferation / negative regulation of extrinsic apoptotic signaling pathway / female pregnancy / positive regulation of protein secretion / positive regulation of glucose import / regulation of cell growth / Post-translational protein phosphorylation / positive regulation of smooth muscle cell proliferation / negative regulation of smooth muscle cell proliferation / regulation of protein phosphorylation / insulin-like growth factor receptor binding / growth factor activity / wound healing / insulin receptor binding / hormone activity / osteoblast differentiation / cellular response to amyloid-beta / Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) / positive regulation of peptidyl-tyrosine phosphorylation / positive regulation of fibroblast proliferation / integrin binding / Platelet degranulation / glucose homeostasis / response to heat / regulation of gene expression / cell population proliferation / Ras protein signal transduction / positive regulation of MAPK cascade / positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction / positive regulation of ERK1 and ERK2 cascade / protein stabilization / negative regulation of translation類似検索 - 分子機能 Insulin-like growth factor binding protein 5 / Omega-AgatoxinV - #20 / Insulin-like growth factor-binding protein family 1-6, chordata / Insulin-like growth factor binding protein, N-terminal, Cys-rich conserved site / Insulin-like growth factor-binding protein (IGFBP) N-terminal domain signature. / Omega-AgatoxinV / Insulin-like growth factor I / Insulin-like, subunit E / Insulin-like / Insulin-like growth factor binding protein ...Insulin-like growth factor binding protein 5 / Omega-AgatoxinV - #20 / Insulin-like growth factor-binding protein family 1-6, chordata / Insulin-like growth factor binding protein, N-terminal, Cys-rich conserved site / Insulin-like growth factor-binding protein (IGFBP) N-terminal domain signature. / Omega-AgatoxinV / Insulin-like growth factor I / Insulin-like, subunit E / Insulin-like / Insulin-like growth factor binding protein / Insulin-like growth factor-binding protein, IGFBP / Insulin-like growth factor-binding protein (IGFBP) N-terminal domain profile. / Insulin growth factor-binding protein homologues / Insulin-like growth factor / Thyroglobulin type-1 repeat signature. / Thyroglobulin type-1 / Thyroglobulin type-1 superfamily / Thyroglobulin type-1 repeat / Thyroglobulin type-1 domain profile. / Thyroglobulin type I repeats. / Insulin family / Insulin/IGF/Relaxin family / Insulin, conserved site / Insulin family signature. / Insulin-like / Insulin / insulin-like growth factor / relaxin family. / Insulin-like superfamily / Growth factor receptor cysteine-rich domain superfamily / Few Secondary Structures / Irregular / Orthogonal Bundle / Mainly Alpha類似検索 - ドメイン・相同性 Insulin-like growth factor I / Insulin-like growth factor I / Insulin-like growth factor-binding protein 5類似検索 - 構成要素 |
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生物種 | HOMO SAPIENS (ヒト) |
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手法 | X線回折 / 単一同系置換 / 解像度: 2.1 Å |
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データ登録者 | Zeslawski, W. / Beisel, H.G. / Kamionka, M. / Kalus, W. / Engh, R.A. / Huber, R. / Holak, T.A. |
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引用 | ジャーナル: Embo J. / 年: 2001 タイトル: The Interaction of Insulin-Like Growth Factor-I with the N-Terminal Domain of Igfbp-5 著者: Zesaawski, W. / Beisel, H.G. / Kamionka, M. / Kalus, W. / Engh, R.A. / Huber, R. / Lang, K. / Holak, T.A. |
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履歴 | 登録 | 2001年5月21日 | 登録サイト: PDBE / 処理サイト: PDBE |
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改定 1.0 | 2002年5月16日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2011年5月8日 | Group: Version format compliance |
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改定 1.2 | 2011年7月13日 | Group: Version format compliance |
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