Entry Database : PDB / ID : 1gt0 Structure visualization Downloads & linksTitle Crystal structure of a POU/HMG/DNA ternary complex Components5'-D(*AP*TP*CP*CP*CP*AP*TP*TP*AP*GP* CP*AP*TP*CP*CP*AP*AP*AP*CP*AP*AP*AP*GP*A)-3'5'-D(*TP*TP*CP*TP*TP*TP*GP*TP*TP*TP* GP*GP*AP* TP*GP*CP*TP*AP*AP*TP*GP*GP*GP*A)-3'OCTAMER-BINDING TRANSCRIPTION FACTOR 1 TRANSCRIPTION FACTOR SOX-2 DetailsKeywords TRANSCRIPTION / TRANSCRIPTION FACTOR / POU FACTORS / SOX PROTEINSFunction / homology Function and homology informationFunction Domain/homology Component
diencephalon morphogenesis / olfactory placode formation / lens induction in camera-type eye / retina morphogenesis in camera-type eye / regulation of myofibroblast cell apoptotic process / detection of mechanical stimulus involved in equilibrioception / pigment biosynthetic process / forebrain neuron differentiation / anatomical structure formation involved in morphogenesis / adenohypophysis development ... diencephalon morphogenesis / olfactory placode formation / lens induction in camera-type eye / retina morphogenesis in camera-type eye / regulation of myofibroblast cell apoptotic process / detection of mechanical stimulus involved in equilibrioception / pigment biosynthetic process / forebrain neuron differentiation / anatomical structure formation involved in morphogenesis / adenohypophysis development / positive regulation of epithelial cell differentiation / response to oxygen-glucose deprivation / endodermal cell fate specification / Deactivation of the beta-catenin transactivating complex / positive regulation of cell-cell adhesion / detection of mechanical stimulus involved in sensory perception of sound / neuron fate commitment / trophectodermal cell differentiation / neuronal stem cell population maintenance / male genitalia development / RNA Polymerase III Transcription Initiation From Type 3 Promoter / RNA Polymerase III Abortive And Retractive Initiation / cell fate specification / tongue development / epithelial tube branching involved in lung morphogenesis / inner ear morphogenesis / stem cell population maintenance / positive regulation of neuroblast proliferation / lung alveolus development / positive regulation of Notch signaling pathway / negative regulation of Wnt signaling pathway / somatic stem cell population maintenance / negative regulation of cell differentiation / inner ear development / RNA polymerase II transcribes snRNA genes / negative regulation of neuron differentiation / regulation of neurogenesis / neuroblast proliferation / negative regulation of osteoblast differentiation / RNA polymerase II core promoter sequence-specific DNA binding / cell fate commitment / embryonic organ development / response to retinoic acid / forebrain development / Notch signaling pathway / cellular response to cadmium ion / positive regulation of neuron differentiation / : / stem cell differentiation / positive regulation of cell differentiation / sensory perception of sound / negative regulation of canonical Wnt signaling pathway / neuron differentiation / brain development / chromatin DNA binding / cerebral cortex development / Wnt signaling pathway / positive regulation of miRNA transcription / osteoblast differentiation / RNA polymerase II transcription regulator complex / gene expression / DNA-binding transcription activator activity, RNA polymerase II-specific / Interleukin-4 and Interleukin-13 signaling / DNA-binding transcription factor binding / Estrogen-dependent gene expression / RNA polymerase II-specific DNA-binding transcription factor binding / transcription regulator complex / sequence-specific DNA binding / transcription cis-regulatory region binding / DNA-binding transcription factor activity, RNA polymerase II-specific / RNA polymerase II cis-regulatory region sequence-specific DNA binding / DNA-binding transcription factor activity / intracellular membrane-bounded organelle / negative regulation of DNA-templated transcription / chromatin binding / regulation of DNA-templated transcription / chromatin / regulation of transcription by RNA polymerase II / negative regulation of transcription by RNA polymerase II / endoplasmic reticulum / positive regulation of transcription by RNA polymerase II / DNA binding / nucleoplasm / identical protein binding / nucleus / cytoplasm Similarity search - Function POU domain, class 2, transcription factor 1, C-terminal / POU domain, class 2, transcription factor 1 C-terminal / Octamer-binding transcription factor / Transcription factor SOX / SOX transcription factor / POU-specific domain / POU domain / Pou domain - N-terminal to homeobox domain / POU-specific (POUs) domain signature 1. / POU-specific (POUs) domain signature 2. ... POU domain, class 2, transcription factor 1, C-terminal / POU domain, class 2, transcription factor 1 C-terminal / Octamer-binding transcription factor / Transcription factor SOX / SOX transcription factor / POU-specific domain / POU domain / Pou domain - N-terminal to homeobox domain / POU-specific (POUs) domain signature 1. / POU-specific (POUs) domain signature 2. / POU-specific (POUs) domain profile. / Found in Pit-Oct-Unc transcription factors / High mobility group box domain / DNA Binding (I), subunit A / Homeobox, conserved site / 'Homeobox' domain signature. / Homeodomain / lambda repressor-like DNA-binding domains / 'Homeobox' domain profile. / Homeodomain / Homeobox domain / HMG (high mobility group) box / HMG boxes A and B DNA-binding domains profile. / 434 Repressor (Amino-terminal Domain) / high mobility group / High mobility group box domain / High mobility group box domain superfamily / Lambda repressor-like, DNA-binding domain superfamily / Homeodomain-like / Homeobox-like domain superfamily / Arc Repressor Mutant, subunit A / Orthogonal Bundle / Mainly Alpha Similarity search - Domain/homologyBiological species HOMO SAPIENS (human)MUS MUSCULUS (house mouse)Method X-RAY DIFFRACTION / SYNCHROTRON / MAD / Resolution : 2.6 Å DetailsAuthors Remenyi, A. / Wilmanns, M. CitationJournal : Genes Dev. / Year : 2003Title : Crystal Structure of a POU/Hmg/DNA Ternary Complex Suggests Differential Assembly of Oct4 and Sox2 on Two EnhancersAuthors : Remenyi, A. / Lins, K. / Nissen, L.J. / Reinbold, R. / Scholer, H.R. / Wilmanns, M. History Deposition Jan 9, 2002 Deposition site : PDBE / Processing site : PDBERevision 1.0 Jan 30, 2003 Provider : repository / Type : Initial releaseRevision 1.1 Nov 14, 2012 Group : Database references / Derived calculations ... Database references / Derived calculations / Non-polymer description / Other / Refinement description Revision 1.2 Jul 24, 2019 Group : Data collection / Category : diffrn_source / Item : _diffrn_source.pdbx_synchrotron_siteRevision 1.3 May 8, 2024 Group : Data collection / Database references / Category : chem_comp_atom / chem_comp_bond / database_2Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession
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