Entry Database : PDB / ID : 1gmi Structure visualization Downloads & linksTitle Structure of the c2 domain from novel protein kinase C epsilon ComponentsPROTEIN KINASE C, EPSILON TYPE Details Keywords KINASE / PKC / C2 DOMAIN / PHOSPHOLIPIDS / PKC EPSILON.Function / homology Function and homology informationFunction Domain/homology Component
DAG and IP3 signaling / positive regulation of cellular glucuronidation / ethanol binding / TRAM-dependent toll-like receptor 4 signaling pathway / SHC1 events in ERBB2 signaling / Role of phospholipids in phagocytosis / diacylglycerol-dependent, calcium-independent serine/threonine kinase activity / Effects of PIP2 hydrolysis / negative regulation of mitochondrial calcium ion concentration / calcium,diacylglycerol-dependent serine/threonine kinase activity ... DAG and IP3 signaling / positive regulation of cellular glucuronidation / ethanol binding / TRAM-dependent toll-like receptor 4 signaling pathway / SHC1 events in ERBB2 signaling / Role of phospholipids in phagocytosis / diacylglycerol-dependent, calcium-independent serine/threonine kinase activity / Effects of PIP2 hydrolysis / negative regulation of mitochondrial calcium ion concentration / calcium,diacylglycerol-dependent serine/threonine kinase activity / protein kinase C / positive regulation of lipid catabolic process / diacylglycerol-dependent serine/threonine kinase activity / regulation of insulin secretion involved in cellular response to glucose stimulus / macrophage activation involved in immune response / regulation of release of sequestered calcium ion into cytosol / presynaptic cytosol / cellular response to ethanol / negative regulation of release of sequestered calcium ion into cytosol / response to morphine / signaling receptor activator activity / positive regulation of fibroblast migration / positive regulation of cell-substrate adhesion / positive regulation of mucus secretion / regulation of synaptic vesicle exocytosis / positive regulation of wound healing / positive regulation of actin filament polymerization / cellular response to platelet-derived growth factor stimulus / positive regulation of epithelial cell migration / positive regulation of cytokinesis / locomotory exploration behavior / negative regulation of mitochondrial membrane potential / regulation of lipid metabolic process / actin monomer binding / regulation of peptidyl-tyrosine phosphorylation / lipopolysaccharide-mediated signaling pathway / enzyme activator activity / negative regulation of protein ubiquitination / 14-3-3 protein binding / T-tubule / cell periphery / positive regulation of synaptic transmission, GABAergic / neuromuscular junction / positive regulation of insulin secretion / SH3 domain binding / cellular response to prostaglandin E stimulus / cellular response to hypoxia / peptidyl-serine phosphorylation / positive regulation of canonical NF-kappaB signal transduction / positive regulation of MAPK cascade / cytoskeleton / cell adhesion / intracellular signal transduction / cell cycle / cell division / Golgi membrane / protein phosphorylation / signaling receptor binding / protein serine/threonine kinase activity / glutamatergic synapse / negative regulation of apoptotic process / protein kinase binding / perinuclear region of cytoplasm / enzyme binding / endoplasmic reticulum / mitochondrion / ATP binding / membrane / nucleus / metal ion binding / plasma membrane / cytoplasm / cytosol Similarity search - Function Protein kinase C, epsilon / Novel protein kinase C epsilon, catalytic domain / Protein kinase C, delta/epsilon/eta/theta types / Protein kinase, C-terminal / Protein kinase C terminal domain / Diacylglycerol/phorbol-ester binding / C2 domain / Phorbol esters/diacylglycerol binding domain (C1 domain) / Zinc finger phorbol-ester/DAG-type signature. / C2 domain ... Protein kinase C, epsilon / Novel protein kinase C epsilon, catalytic domain / Protein kinase C, delta/epsilon/eta/theta types / Protein kinase, C-terminal / Protein kinase C terminal domain / Diacylglycerol/phorbol-ester binding / C2 domain / Phorbol esters/diacylglycerol binding domain (C1 domain) / Zinc finger phorbol-ester/DAG-type signature. / C2 domain / Protein kinase C conserved region 2 (CalB) / Zinc finger phorbol-ester/DAG-type profile. / Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains) / Protein kinase C-like, phorbol ester/diacylglycerol-binding domain / C2 domain / C2 domain profile. / Extension to Ser/Thr-type protein kinases / AGC-kinase, C-terminal / AGC-kinase C-terminal domain profile. / C2 domain superfamily / Serine/threonine-protein kinase, active site / Serine/Threonine protein kinases active-site signature. / Protein kinase domain / Serine/Threonine protein kinases, catalytic domain / Protein kinase, ATP binding site / Protein kinases ATP-binding region signature. / Protein kinase domain profile. / Protein kinase domain / Protein kinase-like domain superfamily / Immunoglobulin-like / Sandwich / Mainly Beta Similarity search - Domain/homologyBiological species RATTUS RATTUS (black rat)Method X-RAY DIFFRACTION / SYNCHROTRON / MIR / Resolution : 1.7 Å DetailsAuthors Ochoa, W.F. / Garcia-Garcia, J. / Fita, I. / Corbalan-Garcia, S. / Verdaguer, N. / Gomez-Fernandez, J.C. CitationJournal : J.Mol.Biol. / Year : 2001Title : Structure of the C2 Domain from Novel Protein Kinase Cepsilon. A Membrane Binding Model for Ca(2+ )-Independent C2 DomainsAuthors : Ochoa, W.F. / Garcia-Garcia, J. / Fita, I. / Corbalan-Garcia, S. / Verdaguer, N. / Gomez-Fernandez, J.C. History Deposition Sep 14, 2001 Deposition site : PDBE / Processing site : PDBERevision 1.0 Oct 25, 2001 Provider : repository / Type : Initial releaseRevision 1.1 May 8, 2011 Group : Version format complianceRevision 1.2 Jul 13, 2011 Group : Version format complianceRevision 1.3 May 8, 2024 Group : Data collection / Database references ... Data collection / Database references / Derived calculations / Other Category : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / database_2 / pdbx_database_status / pdbx_struct_conn_angle / struct_conn Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession ... _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _pdbx_database_status.status_code_sf / _pdbx_struct_conn_angle.ptnr1_auth_comp_id / _pdbx_struct_conn_angle.ptnr1_auth_seq_id / _pdbx_struct_conn_angle.ptnr1_label_asym_id / _pdbx_struct_conn_angle.ptnr1_label_atom_id / _pdbx_struct_conn_angle.ptnr1_label_comp_id / _pdbx_struct_conn_angle.ptnr1_label_seq_id / _pdbx_struct_conn_angle.ptnr3_auth_comp_id / _pdbx_struct_conn_angle.ptnr3_auth_seq_id / _pdbx_struct_conn_angle.ptnr3_label_asym_id / _pdbx_struct_conn_angle.ptnr3_label_atom_id / _pdbx_struct_conn_angle.ptnr3_label_comp_id / _pdbx_struct_conn_angle.ptnr3_label_seq_id / _pdbx_struct_conn_angle.value / _struct_conn.pdbx_dist_value / _struct_conn.ptnr1_auth_comp_id / _struct_conn.ptnr1_auth_seq_id / _struct_conn.ptnr1_label_asym_id / _struct_conn.ptnr1_label_atom_id / _struct_conn.ptnr1_label_comp_id / _struct_conn.ptnr1_label_seq_id / _struct_conn.ptnr1_symmetry / _struct_conn.ptnr2_auth_comp_id / _struct_conn.ptnr2_auth_seq_id / _struct_conn.ptnr2_label_asym_id / _struct_conn.ptnr2_label_atom_id / _struct_conn.ptnr2_label_comp_id / _struct_conn.ptnr2_label_seq_id / _struct_conn.ptnr2_symmetry
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