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Yorodumi- PDB-1g91: SOLUTION STRUCTURE OF MYELOID PROGENITOR INHIBITORY FACTOR-1 (MPIF-1) -
+Open data
-Basic information
Entry | Database: PDB / ID: 1g91 | ||||||
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Title | SOLUTION STRUCTURE OF MYELOID PROGENITOR INHIBITORY FACTOR-1 (MPIF-1) | ||||||
Components | MYELOID PROGENITOR INHIBITORY FACTOR-1 | ||||||
Keywords | CYTOKINE / chemokine / MPIF-1 / CKb8 / CCL23 | ||||||
Function / homology | Function and homology information negative regulation of C-C chemokine binding / lymphocyte chemotaxis / CCR1 chemokine receptor binding / CCR chemokine receptor binding / Formyl peptide receptors bind formyl peptides and many other ligands / chemokine-mediated signaling pathway / chemokine activity / monocyte chemotaxis / cellular response to interleukin-1 / neutrophil chemotaxis ...negative regulation of C-C chemokine binding / lymphocyte chemotaxis / CCR1 chemokine receptor binding / CCR chemokine receptor binding / Formyl peptide receptors bind formyl peptides and many other ligands / chemokine-mediated signaling pathway / chemokine activity / monocyte chemotaxis / cellular response to interleukin-1 / neutrophil chemotaxis / positive regulation of GTPase activity / cellular response to type II interferon / intracellular calcium ion homeostasis / chemotaxis / cell-cell signaling / cellular response to tumor necrosis factor / heparin binding / G alpha (i) signalling events / G alpha (q) signalling events / positive regulation of ERK1 and ERK2 cascade / inflammatory response / immune response / G protein-coupled receptor signaling pathway / negative regulation of cell population proliferation / signal transduction / extracellular space / extracellular region Similarity search - Function | ||||||
Biological species | Homo sapiens (human) | ||||||
Method | SOLUTION NMR / distance geometry, simulated annealing, molecular dynamics | ||||||
Authors | Rajarathnam, K. / Li, Y. / Rohrer, T. / Gentz, R. | ||||||
Citation | Journal: J.Biol.Chem. / Year: 2001 Title: Solution structure and dynamics of myeloid progenitor inhibitory factor-1 (MPIF-1), a novel monomeric CC chemokine. Authors: Rajarathnam, K. / Li, Y. / Rohrer, T. / Gentz, R. | ||||||
History |
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-Structure visualization
Structure viewer | Molecule: MolmilJmol/JSmol |
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-Downloads & links
-Download
PDBx/mmCIF format | 1g91.cif.gz | 715 KB | Display | PDBx/mmCIF format |
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PDB format | pdb1g91.ent.gz | 605.9 KB | Display | PDB format |
PDBx/mmJSON format | 1g91.json.gz | Tree view | PDBx/mmJSON format | |
Others | Other downloads |
-Validation report
Arichive directory | https://data.pdbj.org/pub/pdb/validation_reports/g9/1g91 ftp://data.pdbj.org/pub/pdb/validation_reports/g9/1g91 | HTTPS FTP |
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-Related structure data
Similar structure data |
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-Links
-Assembly
Deposited unit |
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1 |
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NMR ensembles |
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-Components
#1: Protein | Mass: 8869.375 Da / Num. of mol.: 1 Source method: isolated from a genetically manipulated source Source: (gene. exp.) Homo sapiens (human) / Production host: Escherichia coli (E. coli) / Strain (production host): K12-DERIVED STRAIN SGI3009 / References: UniProt: P55773 |
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-Experimental details
-Experiment
Experiment | Method: SOLUTION NMR | ||||||||||||||||||||||||||||||||||||
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NMR experiment |
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-Sample preparation
Details |
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Sample conditions | Ionic strength: 20 mM sodium acetate / pH: 5.2 / Pressure: ambient / Temperature: 308 K | ||||||||||||
Crystal grow | *PLUS Method: other / Details: NMR |
-NMR measurement
NMR spectrometer |
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-Processing
NMR software |
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Refinement | Method: distance geometry, simulated annealing, molecular dynamics Software ordinal: 1 Details: The structures are based on a total of 711 NOE, 82 dihedral, and 36 H-bonding restraints | ||||||||||||
NMR representative | Selection criteria: lowest energy | ||||||||||||
NMR ensemble | Conformer selection criteria: structures with the lowest energy Conformers calculated total number: 50 / Conformers submitted total number: 30 |